scholarly journals Frank-Starling Mechanism and Short-Term Adjustment of Cardiac Flow

2017 ◽  
Author(s):  
José Guilherme Chaui-Berlinck ◽  
Luiz Henrique Alves Monteiro

AbstractThe Frank-Starling Law of the heart is a filling-force mechanism, a positive relationship between the distension of a ventricular chamber and its force of ejection. The functioning of the cardiovascular system is usually described by means of two intersecting curves: the cardiac and vascular functions, the former related to the contractility of the heart and the latter related to the after-load imposed to the ventricle. The crossing of these functions is the so-called operation point, and the filling-force mechanism is supposed to play a stabilizing role for the short-term variations in the working of the system. In the present study, we analyze whether the filling-force mechanism is responsible for such a stability within two different settings: one-ventricle, as in fishes, and two-ventricle hearts, as in birds and mammals. Each setting was analyzed under two scenarios: presence of the filling-force mechanism and its absence. To approach the query, we linearized the region around an arbitrary operation point and put forward a dynamical system of differential equations to describe the relationship among volumes of ventricular chambers and volumes of vascular beds in face of blood flows governed by pressure differences between adjacent compartments. Our results show that the filling-force mechanism is not necessary to give stability to an operation point. The results indicate that the role of the filling-force mechanism is related to decrease the controlling effort over the circulatory system, to smooth out perturbations and to guarantee faster transitions among operation points.Summary StatementWe address the role of the Frank-Starling mechanism and show that it has no role in the stability of the circulatory system. Rather, it accounts for decreasing the controlling effort and speeding up changes in cardiac output.

1990 ◽  
Vol 18 (2) ◽  
pp. 267-277 ◽  
Author(s):  
Janet E. Eschen ◽  
David S. Glenwick

To investigate the possible contributions to dysphoria of interactions among attributional dimensions, 105 freshmen and sophomores were administered the Attributional Style Questionnaire and the Beck Depression Inventory. Analyses examined the relationship to dysphoria of (a) the traditional composite score; (b) multiple regression analyses including interactions among the various dimensions; and (c) indices of behavioral self-blame, characterological self-blame, and external blame. The results provided modest support for the specific hypothesized interactional model and, to a large extent, appeared to support the validity of the standard manner in which dysphoric attributional style is viewed. Refinements of the traditional model are suggested, involving the self-blame construct, the possible role of the stability dimension, and the relationship between controllability and positive event attributions.


2021 ◽  
Vol 1 (12) ◽  
pp. 69-77
Author(s):  
Аleksey V. Zverev ◽  
◽  
Marina Yu. Mishina ◽  
Andrey V. Novikov ◽  
◽  
...  

This article reflects the peculiarities of the psychological connection between a financial fraudster and his potential victim. The process of forming a stressful situation depending on the type of financial fraud is described, the reasons for its occurrence and the result of implementation associated with a decrease in critical thinking are indicated. The essence is also revealed, including from the perspective of the relationship between the fraudster and the potential victim, and the types of financial fraud and practical examples of their manifestation are considered. The psychological portrait of a financial fraudster and his transformation in connection with the changing preferences of consumers of financial services are described. The role of the Bank of Russia in reducing the activity of financial fraud and ensuring the stability of the financial market is reflected.


2021 ◽  
pp. 073401682110383
Author(s):  
Bruno Truzzi ◽  
Marcelo Justus ◽  
Henrique C. Kawamura ◽  
Thomas V. Conti

This article investigates the relationship between the perception of violence and the spending on security goods and services in households. Individual microdata from a random national survey on family budget carried out in Brazil in 2008-2009 were used for modeling the household spending using two instrumental variables. The stability of results was checked by applying the Lasso-Gaussian regularization method in the selection of the statistically significant variables. Positive relationships were found between household spending on security goods and services and (i) the fear of insecurity at the household level, (ii) the neighbors’ spending on security, and (iii) the registered criminality, but no evidence was found on the relationship between the role of police on household spending on security goods and services.


Yurispruden ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 208
Author(s):  
Fahrul Abrori

 ABSTRAKPandemi Covid-19 yang terjadi di Indonesia membuat pemerintah membuat kebijakan-kebijakan sebagai stimulus untuk menjaga kestabilan masyarakat dan perekonomian. Pemerintah pusat memberikan kewenangan kepada pemerintah daerah untuk mengelola keuangan daerah untuk menangani covid-19 di daerah masing-masing. Hal ini disebabkan karena pemerintah daerah lebih memahami kebutuhan daerahnya. Permasalahan yang diangkat Pertama, bagaimana hubungan Pemerintah Pusat dan Pemerintah Daerah dalam pengelolaan keuangan untuk penanganan pandemi Covid-19? Kedua, Apa peran Pemerintah Daerah dalam pengelolaan keuangan daerah untuk penanganan pandemi Covid-19? Menggunakan metode penelitian yuridis normatif dengan pendekatan perundang-undangan dan pendekatan konsep. Hubungan Pemerintah Pusat dan Pemerintah Daerah dalam Pengelolaan Keuangan untuk Penanganan Pandemi Covid-19 yaitu desentralisasi fiskal yang mana. Peran Pemerintah Daerah dalam Pengelolaan Keuangan Daerah untuk Penanganan Pandemi Covid-19 yaitu dengan melakukan refocusing kegiatan, realokasi anggaran, dan Penggunaan Anggaran Pendapatan dan Belanja Daerah.Kata kunci: Pemerintah Daerah, Pengelolaan Keuangan Daerah, Pandemi Covid-19 ABSTRACTThe Covid-19 pandemic in Indonesia led the government to make policies as a stimulus to maintain the stability of society and the economy. The central government authorizes local governments to manage local finances to deal with covid-19 in their respective regions. This is because the local government better understands the needs of the region. The issue raised first, how is the relationship between the Central Government and Local Government in financial management for the handling of the Covid-19 pandemic? Second, What is the role of local governments in regional financial management for the handling of the Covid-19 pandemic? Using normative juridical research methods with statutory approaches and concept approaches. The relationship between the Central Government and Local Government in Financial Management for the Handling of the Covid-19 Pandemic is fiscal decentralization. The role of local governments in regional financial management for the handling of the Covid-19 pandemic is by refocusing activities, reallocating budgets, and using regional budgets.Keywords: Local Government, Regional Financial Management, Covid-19 Pandemic


Author(s):  
Chen Wang ◽  
Yunjun Hu ◽  
Xia Zhang ◽  
Jing Wang ◽  
Guangli Cui ◽  
...  

The aim of the current study was to explore the stability of the mitigating effect of students’ perceived teacher enthusiasm on class-related boredom and the moderating role of boredom proneness and perceived task difficulty in such effect. A total of 984 students from five universities in China participated in the study. Questionnaires on class-related boredom, perceived teacher enthusiasm, boredom proneness, and perceived task difficulty were used to measure the respective variables. Results showed that boredom proneness and perceived task difficulty significantly moderated the relationship between perceived teacher enthusiasm and class-related boredom. Moreover, when considering perceived task difficulty, boredom proneness became silent in the moderating path between perceived teacher enthusiasm and class-related boredom. Even so, the mitigating effect of students’ perceived teacher enthusiasm on class-related boredom was stable in students with different levels of boredom proneness and perceived task difficulty. The implications for learning and teaching are discussed.


Author(s):  
Y.-T. Wu ◽  
A. Adnan

In blast-induced traumatic brain injury, shock waves (SW) play an important role along with cavitation phenomena. Due to the lack of reliable and reproducible experimental investigations, we have a limited understanding of the role of cavitation in brain damage. The present study aims to develop an atomistic simulation model to determine the role of shock-induced impulse and different constituents of the brain’s extra-cellular matrix (ECM) on the formation mechanism, stability and collapsing mechanism of nanobubbles in the ECM. The ECM in the brain can be divided into three major types depending on their location behind the blood-brain barrier, namely (a) the basement membrane (basal lamina), (b) the perineuronal nets and (3) the neural interstitial matrix. In this paper, we have studied the interaction of nanobubbles with bio-molecules of the perineuronal nets. We have chosen this zone of the ECM because we are interested to obtain the role of cavitation bubble collapse in neuron damage. Most biomolecules of perineuronal nets are slender in shape and flexible which is believed to induce special solid-fluid interaction between the fluid domain and the solid domain within the ECM. In addition, perineuronal nets contain a significant number of sodium ions. The relationship between sodium ion and solid-like constituents of perineuronal nets on the stability and the collapsing mechanism of nanobubbles will be discussed.


2017 ◽  
Vol 230 ◽  
pp. 348-370 ◽  
Author(s):  
Catherine R. Schenk

AbstractSince colonial times to the present day, Hong Kong's position as a global financial centre is one of the enduring economic strengths of the territory. This success is often attributed to the distinctive role of the state, coined in the 1970s by the-then financial secretary, Sir Philip Haddon-Cave, as “positive non-interventionism.” The relationship between the market and the state has also been characterized as a form of corporatism, particularly in the financial sector as bankers were able to influence policy. However, closer examination of the behind-the-scenes relations between bankers and the state reveals a much more complex relationship, with the banks seeking protection that the government was not willing to provide. Moreover, the reluctance to regulate financial markets resulted in piecemeal interventions and weak implementation that undermined the stability of this sector and of the economy as a whole. This paper demonstrates the confusion over the concept and practicalities of positive non-interventionism, even for Haddon-Cave, and how the concept evolved towards a policy of “when in doubt, do nothing” during a period of financial instability. Along the way, the paper presents new evidence about the origins of Hong Kong's current banking structure.


2020 ◽  
Vol 8 (1) ◽  
pp. 61-66
Author(s):  
Saiqa Ilham Akbar ◽  
Anisa Nurpita ◽  
Elton Buyung Satrianto

The application of community-based management (CBM) in managing coastal tourism in Indonesia is still limited to providing short-term benefits, especially for local communities and does not guarantee the sustainability of resources at large. On the other hand, most CBM partnership in Indonesia are still limited to the relationship between the local government and local communities and there is no clear partnership scheme in involving the role of third parties and private sectors that can increase the benefits of implementing CBM. This study aims to review and evaluate CBM policies and implementation in the coastal tourism in Indonesia, identifies the effectiveness of CBM implementations, and suggest an optimal CBM partnership scheme in the coastal tourism in Indonesia. The data used are primary data through questionnaires, interviews, and focus group discussion (FGD). Respondents in this study include members of hotel and restaurant association, CBM managers, local government, and businessmen in the coastal tourism area. This study uses investment attractiveness index to measure the effectiveness of CBM in each coastal tourism destination. The findings shows that the implementation of CBM in Indonesian coastal tourism mostly favored the local communities but draws little attention from bigger investment mainly because there is a lack of clear land regulation set by local government in coastal area.


Author(s):  
Marilou Gagnon ◽  
Adrian Guta ◽  
Alayna Payne

Abstract Background Over the last 50 years, there has been a growing interest in and use of contingency management (CM) for people who use substances. Yet, despite showing some level of efficacy (albeit only short-term) and being praised by researchers as beneficial and cost-saving, it continues to be underutilized by health care and service providers. Why that is remains unclear. Methods Recognizing a gap, we conducted a targeted analysis of a larger set of qualitative interviews conducted on the experience of health care and service providers with incentives (including prize-based CM) (n = 25). Results Four themes were identified during the analysis: 1) The specificities of prize-based CM, 2) The role of providers in administering prize-based CM, 3) The positive and negative impact on the relationship, and 4) The ethical concerns arising from prize-based CM. Overall, our findings are consistent with existing literature and suggest that providers are wary of using prize-based CM because they tend to value effort over success, support over reward, honesty over deceit, and certainty over probability and variability. Conclusion Our analysis offers additional insights into the experiences of providers who use prize-based CM and possibly some indications as to why they may not wish to work with this type of incentive. The question raised here is not whether there is enough evidence on the effectiveness of prize-based CM, but rather if this type of incentive is appropriate and ethical when caring for people who use substances.


Author(s):  
Alexander O. Karpov ◽  

Education of the future is a fundamental challenge of the present time that de­fines a horizon of thinking of society and about society. The knowledge society stepping into the role of a horizon brings the substance of the matter to the ability of education to cultivate the creative function of thinking. From the ontological point of view, this article deals with the problem of the education transformation from reproductive to productive forms of working with knowledge (the repro­ductive-productive transition). The prevailing reproductive model of modern ed­ucation is a class-and-lesson (or lecture-seminar) system. Institutionalization of class-and-lesson education in the Reformation years in the XVI c. is ana­lyzed, and key didactic and organizational principles laid down in its basis by Ph. Melanchton are identified. Arguments are presented against qualification of educators in the age of Reformation as humanists. The concept of epistemic dominant is introduced for the purpose of explaining the education transforma­tion process. It is shown that the reproductive-productive transition belongs to the essence of our time. The stability of the class-and-lesson system can be ex­plained by resting on an essential part of educational universals that are timeless in nature. Based on the theory of non-Kuhn’s paradigms, the relationship be­tween the reproductive-productive transition and a shift in the ontological foun­dations of the education phenomenon as to its forms, ways, functions, and gener­alization of its being is shown.


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