scholarly journals Characterising the short-term habituation of event-related evoked potentials

2017 ◽  
Author(s):  
Flavia Mancini ◽  
Alessia Pepe ◽  
Alberto Bernacchia ◽  
Giulia Di Stefano ◽  
André Mouraux ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Event Related Potentials ◽  
Decay Function ◽  
Stimulus Repetition ◽  
Healthy Human ◽  
Related Potentials ◽  
Human Participants ◽  
Main Components ◽  
Skin Receptors

AbstractFast-rising sensory events evoke a series of functionally heterogeneous event-related potentials (ERPs). Stimulus repetition at 1 Hz is known to induce a strong habituation of the largest ERP responses, the vertex waves, which are elicited by stimuli regardless of their modality7, provided that they are salient and behaviourally-relevant. In contrast, the effect of stimulus repetition on the earlier sensor)7 components of ERl’s has been less explored, and the few existing results are inconsistent. To characterize how the different ERP waves habituate over time, we recorded the responses elicited by 60 identical somatosensory stimuli (activating either non-nociceptive A β or nociceptive A5 afferents), delivered at 1 Hz to healthy human participants. We show that the well-described spatiotemporal sequence of lateralised and vertex ERP components elicited by the first stimulus of the series is largely preserved in the smaller-amplitude, habituated response elicited by the last stimuli of the series. We also found that the earlier lateralised sensory waves habituate across the 60 trials following the same decay function of the vertex waves: this decay function is characterised by a large drop at the first stimulus repetition followed by smaller decreases at subsequent repetitions. Interestingly, the same decay functions described the habituation of ERPs elicited by repeated non-nociceptive and nociceptive stimuli. This study provides a neurophysiological characterization of the effect of prolonged and repeated stimulation on the main components of somatosensory ERPs. It also demonstrates that both lateralised waves and vertex waves are obligator}7 components of ERPs elicited by non-nociceptive and nociceptive stimuli.Significance statementOur results provide a functional characterization of the decay of the different ERP components when identical somatosensory (nociceptive and non-nociceptive) stimuli are repeated at 1Hz. East-rising stimuli elicit ERPs obligator)7 contributed by both early lateralised components and late vertex components, even when stimulus repetition minimizes stimulus relevance. This challenges the view that lateralised waves are not obligatorily elicited by nociceptive stimuli. Furthermore, the lateralised and vertex waves habituate to stimulus repetition following similar decay functions, which are unlikely explained in terms of fatigue or adaptation of skin receptors.

scholarly journals Characterization of spatio-temporal epidural event-related potentials for mouse models of psychiatric disorders

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Xin Wang ◽  
António Pinto-Duarte ◽  
M. Margarita Behrens ◽  
Xianjin Zhou ◽  
Terrence J. Sejnowski
Keyword(s):  
Psychiatric Disorders ◽  
Mouse Models ◽  
Event Related Potentials ◽  
Related Potentials ◽  
Spatio Temporal

scholarly journals Anticipatory distractor suppression elicited by statistical regularities in visual search

2019 ◽  
Author(s):  
Benchi Wang ◽  
Joram van Driel ◽  
Eduard Ort ◽  
Jan Theeuwes
Keyword(s):  
Visual Search ◽  
Event Related Potentials ◽  
Cortical Activity ◽  
Irrelevant Information ◽  
Distractor Location ◽  
Alpha Oscillations ◽  
Statistical Regularities ◽  
Related Potentials ◽  
Human Participants

AbstractSalient yet irrelevant objects often capture our attention and interfere with our daily tasks. Distraction by salient objects can be reduced by suppressing the location where they are likely to appear. The question we addressed here was whether suppression of frequent distractors is already implemented beforehand, in anticipation of the stimulus. Using electroencephalography (EEG), we recorded cortical activity of human participants searching for a target while ignoring a salient distractor. The distractor was presented more often at one location than at any other location. We found reduced capture for distractors at frequent locations, indicating that participants learned to avoid distraction. Critically, we found evidence for proactive suppression as already prior to display onset, there was enhanced power in parieto-occipital alpha oscillations contralateral to the frequent distractor location – a signal known to occur in anticipation of irrelevant information. Locked to display onset, event-related potentials analysis showed a distractor-suppression-related PD component for this location. Importantly, this PD was found regardless of whether distracting information was presented at the frequent location. In addition, there was an early PD component representing an early attentional index of the frequent distractor location. Our results are show anticipatory (proactive) suppression of frequent distractor locations in visual search already starting prior to display onset.

scholarly journals High Intellectual Potential and High Functioning Autism: Clinical and Neurophysiological Features in a Pediatric Sample

2021 ◽  
Vol 11 (12) ◽  
pp. 1607
Author(s):  
Assia Riccioni ◽  
Stefano Pro ◽  
Lorena Di Criscio ◽  
Monica Terribili ◽  
Martina Siracusano ◽  
...  
Keyword(s):  
Potential Role ◽  
High Functioning Autism ◽  
Event Related Potentials ◽  
Adaptive Skills ◽  
High Functioning ◽  
Related Potentials ◽  
Autistic Symptoms ◽  
Intellectual Potential

High Intellectual Potential (HIP) and High Functioning Autism (HFA) are two different conditions sharing some clinical and neurobiological features. The aim of the present study was to characterize a sample of HIP children (n: 16; M/F: 14/2; median age: 10 years) in comparison to those with HFA (n: 17; M/F: 16/1; median age: 13 years) and to neurotypically developed (NTD) children (n: 10; M/F: 4/6; median age: 11 years) from a clinical and neurophysiological perspective. Specifically, a standardized clinical assessment of cognitive and adaptive skills, autistic symptoms, executive functions and behavioral features was performed. Moreover, event-related potentials (ERPs) were recorded, referring specifically to the mismatch negativity (MMN) and P300 paradigm. Our data highlighted the presence of similarities between the intellectually gifted individuals and the ones with autism (i.e., a nonhomogeneous intellective profile, an adaptive skills impairment, subthreshold autistic symptoms and increased perfectionism). Interestingly, a distinct neurophysiological characterization between groups came out, with evidence of a reduced MMN amplitude only in the HFA group. Furthermore, no differences within groups in the P300 component emerged. Therefore, our results start to provide a more informative characterization of the HIP phenotype in comparison to those of HFA and NTD, highlighting the potential role of the MMN amplitude index in helping clinicians and researchers to distinguish between HIP and HFA. Nevertheless, further research on the topic is strongly needed.

scholarly journals Perceptual Expectations do not Modulate Image Repetition Effects as Measured by Event-Related Potentials

2017 ◽  
Author(s):  
Daniel Feuerriegel ◽  
Owen Churches ◽  
Scott Coussens ◽  
Hannah A. D. Keage
Keyword(s):  
Event Related Potentials ◽  
Stimulus Presentation ◽  
Repetition Effect ◽  
Stimulus Onset ◽  
List Type ◽  
Stimulus Repetition ◽  
Repetition Effects ◽  
Neuron Response ◽  
Repetition Suppression ◽  
Related Potentials

AbstractRepeated stimulus presentation leads to complex changes in cortical neuron response properties, commonly known as repetition suppression or stimulus-specific adaptation. Circuit-based models of repetition suppression provide a framework for investigating patterns of repetition effects that propagate through cortical hierarchies. To further develop such models it is critical to determine whether (and if so, when) repetition effects are modulated by top-down influences, such as those related to perceptual expectation. We investigated this by presenting pairs of repeated and alternating face images, and orthogonally manipulating expectations regarding the likelihood of stimulus repetition. Event-related potentials (ERPs) were recorded from n=39 healthy adults, to map the spatiotemporal progression of stimulus repetition and expectation effects, and interactions between these factors, using mass univariate analyses. We also tested whether the ability to predict unrepeated (compared to repeated) face identities could influence the magnitude of observed repetition effects, by presenting separate blocks with predictable and unpredictable alternating faces. Multiple repetition and expectation effects were identified between 99-800ms from stimulus onset, which did not statistically interact at any point. Repetition effects in blocks with predictable alternating faces were smaller than in unpredictable alternating face blocks between 117-179ms and 506-652ms, and larger between 246-428ms. ERP repetition effects appear not to be modulated by perceptual expectations, supporting separate mechanisms for repetition and expectation suppression. However, previous studies that aimed to test for repetition effects, in which the repeated (but not unrepeated) stimulus was predictable, are likely to have conflated repetition and stimulus predictability effects.Highlights- ERP face image repetition effects were apparent between 99-800ms from stimulus onset- Expectations of stimulus image properties did not modulate face repetition effects- The predictability of unrepeated stimuli influenced repetition effect magnitudes

scholarly journals Electrophysiological correlates of perceptual prediction error are attenuated in dyslexia

2021 ◽  
Author(s):  
Sara D. Beach ◽  
Sung-Joo Lim ◽  
Carlos Cardenas-Iniguez ◽  
Marianna D. Eddy ◽  
John D. E. Gabrieli ◽  
...  
Keyword(s):  
Prediction Error ◽  
High Probability ◽  
Event Related Potentials ◽  
Control Group ◽  
Perceptual Adaptation ◽  
Stimulus Repetition ◽  
Learning Abilities ◽  
Wide Range ◽  
Related Potentials ◽  
The Difference

A perceptual adaptation deficit often accompanies reading difficulty in dyslexia, manifesting in poor perceptual learning of consistent stimuli and reduced neurophysiological adaptation to stimulus repetition. However, it is not known how adaptation deficits relate to differences in feedforward or feedback processes in the brain. Here we used electroencephalography (EEG) to interrogate the feedforward and feedback contributions to neural adaptation as adults with and without dyslexia viewed pairs of faces and words in a paradigm that manipulated whether there was a high probability of stimulus repetition versus a high probability of stimulus change. We measured three neural dependent variables: expectation (the difference between prestimulus EEG power with and without the expectation of stimulus repetition), feedforward repetition (the difference between event-related potentials (ERPs) evoked by an expected change and an unexpected repetition), and feedback-mediated prediction error (the difference between ERPs evoked by an unexpected change and an expected repetition). Expectation significantly modulated prestimulus theta- and alpha-band EEG in both groups. Unexpected repetitions of words, but not faces, also led to significant feedforward repetition effects in the ERPs of both groups. However, neural prediction error when an unexpected change occurred instead of an expected repetition was significantly weaker in dyslexia than the control group for both faces and words. These results suggest that the neural and perceptual adaptation deficits observed in dyslexia reflect the failure to effectively integrate perceptual predictions with feedforward sensory processing. In addition to reducing perceptual efficiency, the attenuation of neural prediction error signals would also be deleterious to the wide range of perceptual and procedural learning abilities that are critical for developing accurate and fluent reading skills.

Frequency-specific adaptation in human auditory cortex depends on the spectral variance in the acoustic stimulation

2013 ◽  
Vol 109 (8) ◽  
pp. 2086-2096 ◽  
Author(s):  
Björn Herrmann ◽  
Molly J. Henry ◽  
Jonas Obleser
Keyword(s):  
Auditory Cortex ◽  
Event Related Potentials ◽  
Acoustic Stimulation ◽  
Neural Adaptation ◽  
Tone Frequency ◽  
Acoustic Environment ◽  
Response Properties ◽  
Related Potentials ◽  
Spectral Variance ◽  
Human Participants

In auditory cortex, activation and subsequent adaptation is strongest for regions responding best to a stimulated tone frequency and less for regions responding best to other frequencies. Previous attempts to characterize the spread of neural adaptation in humans investigated the auditory cortex N1 component of the event-related potentials. Importantly, however, more recent studies in animals show that neural response properties are not independent of the stimulation context. To link these findings in animals to human scalp potentials, we investigated whether contextual factors of the acoustic stimulation, namely, spectral variance, affect the spread of neural adaptation. Electroencephalograms were recorded while human participants listened to random tone sequences varying in spectral variance (narrow vs. wide). Spread of adaptation was investigated by modeling single-trial neural adaptation and subsequent recovery based on the spectro-temporal stimulation history. Frequency-specific neural responses were largest on the N1 component, and the modeled neural adaptation indices were strongly predictive of trial-by-trial amplitude variations. Yet the spread of adaption varied depending on the spectral variance in the stimulation, such that adaptation spread was broadened for tone sequences with wide spectral variance. Thus the present findings reveal context-dependent auditory cortex adaptation and point toward a flexibly adjusting auditory system that changes its response properties with the spectral requirements of the acoustic environment.

scholarly journals Hits-Based Quantitative Characterization of SOBI-Recovered P3 Network Configuration: an EEG Source-Imaging Study

2020 ◽  
Author(s):  
Adam John Privitera ◽  
Renee Fung ◽  
Yunqing Hua ◽  
Akaysha C. Tang
Keyword(s):  
Brain Structure ◽  
Spatial Configuration ◽  
Event Related Potentials ◽  
Special Role ◽  
Quantitative Characterization ◽  
Source Imaging ◽  
Eeg Source Imaging ◽  
Related Potentials ◽  
P3 Component

AbstractOne frequently studied biomarker for health and disease conditions is the P3 component extracted from scalp recorded electroencephalography (EEG). The spatial origin of this significant neural signal is known to be distributed, typically involving large regions of the cerebral cortex as well as subcortical structures. Unlike the temporal characterization of the P3 by amplitude or latency measures from event-related potentials (ERPs), the spatial characterization of the P3 component is relatively rare, typically qualitative, and often reported as differences between populations (group differences between healthy controls and clinical groups). Here we introduce a novel approach to quantitatively characterize the spatial origin of the P3 component by (1) applying second-order blind identification (SOBI) to continuous, high-density EEG data to extract the P3 component, (2) modeling the underlying generators of the SOBI P3 component as a set of equivalent current dipoles (ECDs) in Talairach space using BESA; (3) using the application Talairach Client to determine the “hits” associated with the anatomical structures at three level of resolution (lobe, gyrus, and cell type). We show that the hits information provided by Talairach Client can enable a quantitative characterization of the spatial configuration of the network underlying the P3 component (P3N) via two quantities: cross-individual reliability (or consistency) of a given brain structure as a part of the P3N, and within-individual contribution of a given brain structure to the whole P3N network. We suggest that this method may be used to further differentiate individuals in the absence of differences in P3 amplitude or latency, or when scientific questions or practical application cannot be supported by a yes-no answer regarding the source of a P3 component. Finally, application of our method to a group of 13 participants revealed that frontal structures, particularly BA10, play a special role in the function of a global cortical network underlying novelty processing.

scholarly journals Recollection is more than retrieving context or source memory: evidence from ERPs of Recognition and Source Memory combinations

2020 ◽  
Author(s):  
Richard J. Addante ◽  
Alana Muller ◽  
Lindsey A. Sirianni
Keyword(s):  
Source Memory ◽  
Response Times ◽  
Event Related Potentials ◽  
Individual Variability ◽  
List Type ◽  
Opposite Pattern ◽  
Physiological Characterization ◽  
Related Potentials ◽  
The Individual

AbstractThe goal of this study was to investigate a relatively unstudied memory condition for paradoxical combinations of item + source memory confidence responses, which challenged the conventional views of the memory processes supporting item and source memory judgments. We studied instances in which people provided accurate source memory judgments (conventionally ascribed as representing recollection) after having first produced low- confidence item recognition hits for the same items (conventionally thought to reflect familiarity-based processing). This paradoxical combination does not fit traditional accounts of being recollection (because it had low-confidence recognition) nor accounts of familiarity (since it had accurate source memory), and event-related potentials (ERPs) were used to adjudicate which processes support these kinds of memories. ERP results were unlike the conventional ERP effects of memory, lacking both an FN400 and the parietal old-new effect (LPC), and instead exhibited a significant negative-going ERP effect occurring later in time (800-1200ms) in central-parietal sites. Behavioral measures of response times revealed a crossover interaction: low confident recognition hits were slower during recognition but faster during source memory when compared to the opposite pattern seen for instances of high confident hits. Results provide a comprehensive characterization of the individual variability of the FN400 and LPC effects of memory, while adding the behavioral and physiological characterization of a late negative-going ERP effect for accurate source memory without recollection. Conclusions indicated that episodic context could be retrieved independently from recollection, while suggesting a role for a process of context familiarity that is independent from item-familiarity.HighlightsRecollection is often defined as remembering the source or context of informationPrior work used ERPs to identify times when source memory did not have recollectionCurrent work replicated ERPs with added response times and measures of varianceRecollection was not evident in certain source memories, which had a negative ERPRecollection is independent of context and is more than just remembering sourcesGraphical Abstract

scholarly journals Memory, consciousness and neuroimaging

1998 ◽  
Vol 353 (1377) ◽  
pp. 1861-1878 ◽  
Author(s):  
◽  
D. L. Schacter ◽  
R. L. Buckner ◽  
W. Koutstaal
Keyword(s):  
Brain Activity ◽  
Sense Of Self ◽  
Memory Performance ◽  
Event Related Potentials ◽  
Neural Correlates ◽  
Healthy Human ◽  
Positron Emission ◽  
Conscious Recollection ◽  
Related Potentials

Neuroimaging techniques that allow the assessment of memory performance in healthy human volunteers while simultaneously obtaining measurements of brain activity in vivo may offer new information on the neural correlates of particular forms of memory retrieval and their association with consciousness and intention. We consider evidence from studies with positron emission tomography and functional magnetic resonance imaging indicating that priming, a form of implicit retrieval, is associated with decreased activity in various cortical regions. We also consider evidence concerning the question of whether two components of explicit retrieval—intentional or effortful search and successful conscious recollection— are preferentially associated with increased activity in prefrontal and medial temporal regions, respectively. Last, we consider recent efforts to probe the relation between the phenomenological character of remembering and neural activity. In this instance we broaden our scope to include studies employing event–related potentials and consider evidence concerning the neural correlates of qualitatively different forms of memory, including memory that is specifically associated with a sense of self, and the recollection of particular temporal or perceptual features that might contribute to a rich and vivid experience of the past.

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