scholarly journals Women’s estimated HIV infections from sex in trials of pre-exposure prophylaxis in Africa: Implications for HIV prevention strategies

2017 ◽  
Author(s):  
David Gisselquist
Keyword(s):  
Hiv Prevention ◽  
Hiv Infections ◽  
Common Belief ◽  
Prevention Strategies ◽  
Sexual Risks ◽  
Hiv Prevention Strategies ◽  
Vaginal Gels ◽  
Vaginal Rings ◽  
Exposure Prophylaxis ◽  
Oral Prep

AbstractIntroductionDuring 2004-15, nine randomized controlled trials (RCT) for HIV prevention tested pre-exposure prophylaxis (PrEP) with oral drugs, vaginal gels, or vaginal rings among more than 17,000 women in Africa.MethodsThis study uses information from the nine RCTs to estimate the proportions of HIV from sexual and bloodborne risks, to consider reasons for success or failure with oral PrEP, and to consider risks with vaginal PrEP.ResultsEstimating from women’s reported frequencies of unprotected coital acts in six RCTs, only a minority of women’s infections came from sex. Oral PrEP may have succeeded in at least one trial by reducing infections from both bloodborne and sexual risks. Oral PrEP may have failed in several trials, at least in part, because some women used oral PrEP when they had sexual risks rather than daily as advised. Relatively high incidence with PrEP vaginal gels and rings vs. oral placebo suggests vaginal PrEP had little impact at best and may have been harmful.DiscussionEvidence from this and other studies challenges the common belief most HIV in Africa comes from sex. This challenge has implications for HIV prevention strategies, including: warning about bloodborne risks; and reconsidering PrEP for young women.

scholarly journals Birth Cohort Variations Across Functional Knowledge of HIV Prevention Strategies, Perceived Risk, and HIV-Associated Behaviors Among Gay, Bisexual, and Other Men Who Have Sex With Men in the United States

2018 ◽  
Vol 12 (6) ◽  
pp. 1824-1834 ◽  
Author(s):  
Akshay Sharma ◽  
Erin M. Kahle ◽  
Stephen P. Sullivan ◽  
Rob Stephenson
Keyword(s):  
Hiv Prevention ◽  
Birth Cohort ◽  
Perceived Risk ◽  
The United States ◽  
Prevention Strategies ◽  
The Past ◽  
Hiv Prevention Strategies ◽  
Functional Knowledge ◽  
Sex With Men ◽  
Exposure Prophylaxis

Gay, bisexual, and other men who have sex with men (GBMSM) in the United States remain heavily impacted by HIV. The purpose of this study was to describe intergenerational differences in functional knowledge of HIV prevention strategies, perceived risk, recent condomless anal sex (CAS), and HIV testing behavior. Eight hundred sexually active GBMSM were recruited via Facebook from August to September 2015, and administered a Web-based survey which included 12 multiple-choice questions to elicit data regarding functional knowledge of different HIV prevention approaches (e.g., condom use, pre-exposure prophylaxis post-exposure prophylaxis, treatment as prevention, circumcision). Cumulative logit and multivariable logistic models were formulated to examine birth cohort variations across four analytic outcomes. Younger generations were significantly more knowledgeable, as were GBMSM with higher education. Non-Hispanic non-White GBMSM and those reporting a bisexual/other sexual orientation had lower functional knowledge. Younger generations were equally concerned about contracting HIV as their older counterparts. Perceived risk was significantly higher among non-Hispanic non-White and Hispanic GBMSM, but lower among those with higher education and those in a relationship. Finally, birth cohort variations with respect to engaging in CAS with ≥2 men in the past 3 months and testing for HIV in the past year were not markedly pronounced. Younger GBMSM might be more knowledgeable about HIV prevention strategies compared to their predecessors, but are equally concerned about contracting HIV. Researchers and practitioners should consider intergenerational and other demographic differences while designing multifaceted HIV prevention programs for GBMSM.

scholarly journals HIV prevention strategies and risk of infection: a model-based analysis

2018 ◽  
Vol 146 (8) ◽  
pp. 1015-1025 ◽  
Author(s):  
A. Hahn ◽  
R. Hinz ◽  
T. Meyer ◽  
U. Loderstädt ◽  
O. Herchenröder ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Condom Use ◽  
Hiv Transmission ◽  
Hiv Infections ◽  
Risk Groups ◽  
Unprotected Sex ◽  
Transmission Risk ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
Hiv Transmission Risk

AbstractRisk populations for HIV infections tend to neglect condom use, making alternative preventive approaches necessary. Accordingly, we modelled the risk of sexual HIV transmission for condom usevs.use of rapid diagnostic test (RDT) systems with subsequent exclusion of potential sexual partners with a correctly or falsely positive test from unprotected sex with and without the use of HIV pre-exposure prophylaxis (PrEP) in a bio-statistical approach. We combined a previously described model of transmission risk for HIV-exposed individuals with a newly suggested model of risk of HIV exposure for sexually active HIV-negative individuals. The model was adapted for several stages of infection and different strategies of HIV infection prevention.HIV prevention with RDTs can reduce the transmission risk by up to 97% compared with having sex without any prevention and up to 80% compared with condom use. Nevertheless, RDT-based prevention strategies demonstrate a lack of protection in several stages of infection; in particular, RNA-based RDT systems may fail under treatment. RDT-based pre-screening of potential sex partners prior to unprotected sexual contacts substantially reduces HIV transmission risk. Combination of different prevention strategies is advisable for high-risk groups.

scholarly journals Quality of HIV Websites With Information About Pre-Exposure Prophylaxis or Treatment as Prevention for Men Who Have Sex With Men: Systematic Evaluation (Preprint)

2018 ◽  
Author(s):  
Taylor Silverman ◽  
Nicole Asante ◽  
Jacob J van den Berg
Keyword(s):  
Hiv Prevention ◽  
Hiv Infection ◽  
Rating Scale ◽  
The United States ◽  
Treatment As Prevention ◽  
Key Words And Phrases ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
Sex With Men ◽  
Exposure Prophylaxis

BACKGROUND Knowledge and uptake of high-efficacy HIV prevention strategies such as pre-exposure prophylaxis (PrEP) and treatment as prevention (TasP) remain low among men who have sex with men (MSM) who are at the highest risk for HIV infection in the United States. Electronic health (eHealth) interventions are promising tools for disseminating information about these critical yet underutilized strategies and addressing key barriers to uptake among target populations. However, existing HIV prevention websites are understudied and unevaluated. OBJECTIVE This study aimed to systematically review and evaluate existing HIV websites that include information about PrEP or TasP for MSM. METHODS From March 2018 to May 2018, 2 trained research assistants (RAs) entered relevant key words and phrases into 3 commonly used search engines and applied exclusion criteria to all returned results to identify 31 websites included in this review. RAs independently scored each website for authority, usability, interactivity, and PrEP/TasP-related content based on a standardized rating scale and then averaged the results. RESULTS No website received a perfect score in any of the 4 categories, and the average website score was 62% (37/60). Less than a quarter of the websites (23%, 7/31) received a score of more than 75% (7.5/10) for content. Approximately two-thirds of the websites (65%, 20/31) received a score of 50% (5/10) or lower for interactivity. The average score in usability was 68% (6.8/10) and in authority was 69% (6.9/10). Other deficiencies observed included difficulty locating relevant content and lack of information targeting audiences with the highest likelihood of HIV infection. CONCLUSIONS Existing HIV prevention websites with information about PrEP or TasP for MSM fail to provide adequate content as well as present that content to users in an interactive and audience-conscious way. Future eHealth interventions should attempt to rectify these deficiencies to successfully engage and educate MSM at high risk for HIV regarding prevention strategies.

scholarly journals Awareness, Utilization, and Preferences for Traditional and Contemporary HIV Prevention Strategies Among Facebook and Instagram-Using MSM in the United States

2021 ◽  
Vol 20 ◽  
pp. 232595822110247
Author(s):  
Akshay Sharma ◽  
Ariana Paredes-Vincent ◽  
Erin M. Kahle
Keyword(s):  
Hiv Prevention ◽  
The United States ◽  
Easy Access ◽  
Individual Risk ◽  
Post Exposure Prophylaxis ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
And Bisexual ◽  
Sex With Men ◽  
Exposure Prophylaxis

HIV prevention research among men who have sex with men (MSM) has traditionally focused on individual risk reduction strategies. Our study evaluated awareness, utilization, and preferences for 10 complementary HIV prevention strategies among 1,286 MSM recruited via Facebook and Instagram from June-August 2018. Ages ranged from 18-85 years, and the majority were non-Hispanic white (n = 1,019, 79.24%), college-educated (n = 819, 63.69%), gay-identifying (n = 1,074, 83.51%), and partnered (n = 808, 62.83%). Post-exposure prophylaxis was the least familiar option, and engaging in sexual activities other than anal sex was the most utilized option. Progressively older and bisexual-identifying MSM were less likely, but those with higher educational levels and easy access to local HIV resources were more likely to be aware of and to be utilizing a greater number of strategies. Additionally, Hispanic MSM were less likely to be aware of, and those in a “closed” relationship were less likely to be utilizing a greater number of strategies. In a subset of 775 multiple strategy users, pre-exposure prophylaxis, regularly testing for HIV, and limiting the number of sex partners emerged as the most preferred options. Combination intervention packages for MSM should be tailored to personal circumstances, including sexual orientation, relationship characteristics and access to local HIV resources.

Role of Oral Pre-exposure Prophylaxis (PrEP) in Current and Future HIV Prevention Strategies

2014 ◽  
Vol 11 (4) ◽  
pp. 393-403 ◽  
Author(s):  
David N. Burns ◽  
Cynthia Grossman ◽  
Jim Turpin ◽  
Vanessa Elharrar ◽  
Fulvia Veronese
Keyword(s):  
Hiv Prevention ◽  
Prevention Strategies ◽  
Hiv Prevention Strategies ◽  
Exposure Prophylaxis

scholarly journals A NOVEL OF BIOMEDICAL APPROACH FOR HIV PREVENTION: AN INTEGRATED LITERATURE REVIEW

2017 ◽  
Vol 3 (1) ◽  
pp. 39
Author(s):  
Linlin Lindayani
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Prevention ◽  
Hiv Infections ◽  
Current Evidence ◽  
Cochrane Library ◽  
Post Exposure Prophylaxis ◽  
Prevention Strategies ◽  
Post Exposure ◽  
Immunodeficiency Virus ◽  
Exposure Prophylaxis

ABSTRAKSecara global, jumlah kasus baru terinfeksi Human Immunodeficiency Virus (HIV) sudah mengalami penurunan yang signifikan. Akan tetapi dibeberapa wilayah negara seperti Afrika dan Asia Tenggara, jumlah kasus baru terinfeksi HIV masil mengalami peningkatan. Upaya pencegahan seperti promosi penggunaan kondom, sunat bagi laki-laki, dan skrining HIV sudah diimpementasikan dengan baik. Tetapi, pendekatan tersebut tetap saja tidak menghilangkan seseorang terkena resiko HIV bahkan mungkin untuk pasangan yang hidup dengan penderita HIV malah meningkatan resiko mereka tertular HIV. Sehingga dibutuhkan suatu pendekatan lain yang efekti dan mampu meminimalkan sekecil-kecilnya resiko seseorang tertular HIV. Tujuan dari review ini adalah untuk mengkaji efektifitas pendekatan baru yang dikenal dengan pendekatan biomedik terhadap penurunan resiko tertular HIV. Melalui pencarian secara komprehensif di beberap sumber data seperti PubMed, Embase, Cochrane Library, clinicaltrials.gov, htpn.org, and meta-register dilakukan terutama berfokus pada studi yang diterbitkan dalam Bahasa Inggris pada tahun 2005 sampai 2015. Hasil dari pengkajian tersebut menunjukan bahwa pendekatan biomedik seperti pre-exposure prophylaxis (PrEP) dan post exposure prophylaxis (PEP) merupakan suatu pendekatan yang terbukti efektif dalam menurunkan penularan HIV terutama pada kelompok-kelompok dengan resiko tinggi seperti homoseksual atau heteroseksual. Sehingga, pemerintah Indonesia mungkin sudah bisa melakukan pengkajian yang dalam dan membuat pedoman tatalaksana pencegahan HIV dengan pendekatan ini. ABSTRACTThe number of new cases of Human Immunodeficiency Virus (HIV) infections has decreased significantly worldwide. However, in some regions such as Africa and South East Asian, new HIV infections remain high. Prevention strategies such as promoting condom use, male circumcision, and early HIV detection have been implemented well. However, all those approaches still putting people at high risk of HIV infection. The purpose of this review is to summarize current evidence about biomedical approach as an effective HIV prevention. A comprehensive computerized literature search was conducted using PubMed, Embase, Cochrane Library, clinicaltrials.gov, htpn.org, and meta-register to retrieved relevant literature published from 2005 to 2015 in English to review a current approach for HIV prevention. Biomedical approaches using antiretroviral drugs have shown good efficacy in the prevention of mother-child transmission for post exposure prophylaxis. Recent evidence has also found pre-exposure prophylaxis (PrEP) to be promising in preventing HIV. Both WHO and CDC recommended to integrate PrEP and post exposure prophylaxis for HIV prevention strategies. Health care policy needs to consider the biomedical approach to HIV prevention, especially in Indonesia. Therefore, Indonesia government may start to develop a clinical guideline and deeply assess the possibility to implement this approach in clinical practice.Keywords: biomedical approach, prevention, HIV, treatment

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