scholarly journals A Sign of Disparity: Racial/Ethnic Composition of Treatment Centers is an Independent Risk Factor in SPRINT Trial

2017 ◽  
Author(s):  
Matthew Matlock ◽  
Na Le Dang ◽  
David Brown ◽  
S. Joshua Swamidass
Keyword(s):  
Myocardial Infarction ◽  
Risk Factor ◽  
Relative Risk ◽  
Health Outcomes ◽  
Social Determinants ◽  
Independent Risk Factor ◽  
Strong Influence ◽  
Ethnic Composition ◽  
Hypertensive Patients ◽  
Racial Ethnic

AbstractThe racial composition of treatment centers in the SPRINT trial is an independent risk factor for myocardial infarction (MI) and stroke. Independent of individual race or ethnicity, patients face a 39% increase in relative risk of MI or stroke when associated to treatment centers with a high proportion of African Americans. The magnitude of this effect is comparable to smoking. This suggests the strong influence of social determinants on health outcomes among hypertensive patients.

scholarly journals Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

2012 ◽  
Vol 35 (11) ◽  
pp. 1087-1092 ◽  
Author(s):  
Tatsuo Kawai ◽  
Mitsuru Ohishi ◽  
Yasushi Takeya ◽  
Miyuki Onishi ◽  
Norihisa Ito ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Hypertensive Patients

scholarly journals Impact of ventricular arrhythmias on survival in patients after myocardial infarction

2014 ◽  
Vol 1 (1) ◽  
pp. 21 ◽  
Author(s):  
Katarzyna Anna Mitręga ◽  
Agnieszka Kolczyńska ◽  
Joanna Hanzel ◽  
Sylwia Cebula ◽  
Stanisław Morawski ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Risk Factor ◽  
Ventricular Arrhythmias ◽  
Independent Risk Factor ◽  
Premature Ventricular Beats ◽  
Large Numbers ◽  
Ventricular Extrasystoles ◽  
Long Term Follow Up

Introduction: Despite the continuous development of new methods of pharmacological and invasive treatment for patients with acute myocardial infarction (MI) the prognosis of long-term survival is still uncertain. Therefore, there is still need to look for new noninvasive predictors of death in patients after MI. Aim: To analyze the prognostic value of ventricular arrhythmias in predicting mortality following MI in long-term follow-up. Methods: We analyzed 390 consecutive patients (114 females and 276 males, aged 63.9 ± 11.15 years, mean EF: 43.8 ± 7.9%) with MI treated invasively.  On the 5th day after MI 24-hour digital Holter recording was performed to assess the number of premature ventricular beats (VPB) and their sustained forms such as: salvos and nonsustained ventricular tachycardia (nsVT <  30 s). The large numbers of ventricular extrasystoles: ≥ 10 VPB / hour were considered as abnormal. In echocardiography the size of heart cavities and cardiac contractile function were evaluated. Within 30.1 ± 15.1 months of follow-up 38 patients died. Results: In the group of patients with MI the mean value of ventricular ectopy during the day was: 318.8 ± 1447.6. Large numbers of ventricular extrasystoles were observed in 75% patients, while nsVT in 6% patients. Significant differences in the incidence of death after MI were observed in patients with nsVT and ventricular salvos. In the group of patients who died in comparison to the group of patients who survived in long-term follow-up, a significantly less ventricular ectopic incidence was noted (9.83% vs 90.17%, p < 0.01). In patients who died after MI more premature ventricular beats (≥ 10 VPB / h) and a greater nsVT incidence were observed; however not significant. Moreover, in patients with MI the systolic and diastolic LV dimension, decreased values of hemoglobin, salvos and nsVT incidence are the independent risk factors of death. The strongest independent risk factor of death after MI is salvos (HR: 1.32, P < 0.01). Conclusions: In long term follow-up the largest differences in death were observed in patients with ventricular salvos and nsVT. Furthermore, ventricular salvos are the strongest independent risk factor of death in patients with AMI. 

Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age

1990 ◽  
Vol 36 (1) ◽  
pp. 20-23 ◽  
Author(s):  
M Sandkamp ◽  
H Funke ◽  
H Schulte ◽  
E Köhler ◽  
G Assmann
Keyword(s):  
Myocardial Infarction ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Apolipoprotein B ◽  
Independent Risk Factor ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Major Influence ◽  
Lipoprotein A ◽  
Apolipoprotein E Polymorphism

Abstract We quantified lipoprotein(a) [Lp(a)] immunochemically in young (less than 46 y) male survivors of myocardial infarction and in age-matched controls recruited from participants of the Prospective Cardiovascular Münster (PROCAM) study. We further determined apolipoprotein E polymorphism and measured triglycerides, total cholesterol, high- and low-density lipoprotein cholesterol (HDL and LDL), and apolipoproteins AI, AII, and B in the serum of these subjects. Lp(a) concentrations in serum were not correlated with other well-recognized risk factors for early myocardial infarction such as apolipoproteins AI and B, LDL cholesterol, and HDL cholesterol. Apolipoprotein E polymorphism did not affect Lp(a) concentrations, but had a major influence on apolipoprotein B concentration. Lp(a) concentrations were not influenced by age. Our data suggest that (a) an increased concentration of Lp(a) constitutes an independent risk factor for early myocardial infarction and (b) the concentrations of Lp(a) and LDL cholesterol (apolipoprotein B) in serum are under separate metabolic control.

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