scholarly journals First Indications for Long-Term Benzodiazepine and Z-drugs use in the United Kingdom

2016 ◽  
Author(s):  
James Davies ◽  
Todd Rae ◽  
Luke Montagu

Benzodiazepines and Z-drugs (BZDs), hypnotic drugs used for insomnia and anxiety, are prescribed millions of times a year in the UK. Although guidance from the relevant regulatory authorities (NICE and BNF) indicates them only for short-term use, the evidence suggests that many patients have been taking these drugs for much longer, often for decades. At present, there are no up-to-date, evidence-based estimates of the scale of long-term BZD use in the UK, which has prevented making a strong case for the need for withdrawal services. However, data obtained recently on BZD use from a number of GP surgeries (covering nearly 100,000 registered patients) in the North of England, allow such projections to be calculated. Scaling the results to a national level suggests that there are over a quarter of a million patients in the UK using BZDs for periods far longer than recommended. The projections also suggest that nearly half this number may be willing to accept help to stop their dependency on BZDs. These results indicate a serious problem, which should be addressed by more research into the harms associated with long-term BZD use, the provision of withdrawal services, and a national helpline to support patients with BZD dependency.

2016 ◽  
Vol 23 (4) ◽  
pp. 454-484 ◽  
Author(s):  
Robert Dunbar

In spite of the long-term dominance in Britain and Ireland of English, other indigenous languages continue to be spoken, and in relatively recent years several of those languages have benefited not only from a more coherent and supportive language policy but also from significant language legislation. One of the interesting features of these other indigenous languages is that, although strongly associated with rural ‘heartlands’ in the particular jurisdictions with which they are associated, they are also spoken in other parts of those jurisdictions, and, indeed, in other parts of the United Kingdom and Ireland. In this article, the ways in which the concept of territoriality has impacted upon legislation and on broader policy for two of these languages, Irish and Scottish Gaelic, will be considered.


Author(s):  
Thomas Klammer ◽  
Neil Wilner ◽  
Jan Smolarski

Capital expenditures can be crucial to firms long-term success, especially in a complex global environment. As companies increasingly compete in the global market place, it is important to study project evaluation processes from an international perspective. Capital investments involve substantial monetary commitments and risks that affect long-term firm profitability and influence capital allocation decisions in the future. Survey research in the area of capital expenditure analysis has been extensively done in both the United States [US] and the United Kingdom [UK]. This research is the first comparative survey of practices in both countries that we are aware of. A direct comparison of the use of project evaluation, management science, and risk management techniques in the two countries is made. The survey instrument used is an adaptation of the Klammer [1970] instrument that has been used repeatedly in surveys of American firms. This is the first time that it has been applied to British firms. The use of a common instrument allows for more meaningful comparisons. The samples consisted of 127 American and 59 British firms with sales of at least $100 million and capital expenditures of at least $10 million. Preliminary results indicate a continued extensive use of discounted cash flow techniques by US firms. Techniques such as payback or urgency continue to be used, but to a lesser degree than discounting. Firms in the UK also make extensive use of discounting but do so to a lesser degree than their American counterparts. Payback is widely used in the UK. Risk management techniques are widely used in both countries, with sensitivity analysis being the most popular technique in both countries. Extensive use of technical and administrative procedures, such as detailed budgets, standardized forms and post-audits, are evidenced in both countries. The paper offers reasons that have to do with organizational structure and form, as well as market differences, to explain our results.


2021 ◽  
Author(s):  
Lea Ellwardt ◽  
Patrick Praeg

Aim. The COVID-19 pandemic and the mitigation measures by governments have upended the economic and social lives of many, leading to widespread psychological distress. However, how distress developed during the pandemic and who was most affected is poorly understood. We explore heterogeneity in trajectories of psychological distress during the first six months of the pandemic in the United Kingdom and relate this heterogeneity to socio-demographic and health factors. Subjects and Methods. We analyze six waves of longitudinal, nationally representative survey data from the UK Household Longitudinal Study (N = 15,218), covering the first lockdown in 2020. First, latent class mixture modelling (LCCM) is used to identify trajectories of psychological distress. Second, associations of the trajectories with covariates are tested with multinomial logistic regressions. Results. We find four different trajectories of distress: continuously low, continuously moderate, temporarily elevated, and continuously elevated distress. One-fifth of the population experienced severely elevated risks of distress. Long-term exposure was highest among younger people, women, those who lost income, and those with previous health conditions or COVID-19 symptoms. Conclusion. Given the threat of persistent stress on health, policy measures should be sensitized to the unintended yet far-reaching consequences of non-pharmaceutical interventions.


2021 ◽  
Vol 36 (1) ◽  
pp. 155-164
Author(s):  
Richard Barnes

Abstract On 30 September 2020, the United Kingdom and Norway signed the Framework Agreement on Fisheries that will provide the basis for future cooperation in the sustainable management of their fisheries. The Agreement is the first such agreement adopted by the UK following its decision to the leave the European Union. This note provides some background to the Agreement and examines its key features. Whilst the content of the Agreement appears to be rather basic, this is broadly consistent with other framework agreements, and it does provide some insight into the direction and focus of fisheries management in the North Sea, and how cooperation may develop between coastal States and the European Union.


2021 ◽  
Vol 855 (1) ◽  
pp. 012015
Author(s):  
B Dams ◽  
D Maskell ◽  
A Shea ◽  
S Allen ◽  
V Cascione ◽  
...  

Abstract Non-residential circular construction projects using bio-based materials have been realised in the United Kingdom. Case studies include the Adnams Distribution Centre, the University of East Anglia’s Enterprise Centre and the British Science Museum’s hempcrete storage facility. The bio-based buildings utilise the natural properties of bio-based materials to insulate and regulate internal environments, particularly with reducing fluctuations in temperature and relative humidity, which can be harmful to sensitive stored products and artefacts. Projects have been successful on both on environmental and physical performance levels; however, they have not led to a subsequent proliferation of non-residential large-scale circular projects within the UK using emerging bio-based materials. This study examines why and uses analysis based upon exclusive interviews with key figures associated with bio-based case studies. Challenges faced include the ability to upscale production by manufacturers of bio-based materials, problems surrounding initial costs, gaining accreditation for materials, the vested interests present in the construction industry and levels of knowledge among clients and construction professionals. Potential upscaling solutions identified include long-term financial savings on running costs and high staff productivity, policies regarding grants, incentives and planning applications and local economic regeneration.


2021 ◽  
Vol 36 (2) ◽  
Author(s):  
Rachma Puspitasari ◽  
Raldi Koestoer

The ocean is a source of mega-biodiversity that is supposed to perform optimally for current and future generations. The health of the ocean must be evaluated by measuring heavy metals in sediment because they can be accumulated and stored in long term. This metal can be released and absorbed by an organism, and affect the ecological risk and human health. The purpose of this article is to share viewpoints and those in a comparative study in terms of the metal database of both countries, the UK and Indonesia. The methodology used in this paper is critical review and analysis to compare a success story about compiling metal data into a national database in the United Kingdom (UK). Indonesia already has an open public access database issued by the Ministry of Environment and Forestry. The further step is to strengthen collaboration between research institutes, universities, and government to assign a Standard Operational Procedure (SOP) to collect, analyze and report the data to a national depository. This database will be worthwhile to describe the pollution status in Indonesia and basic data for best practice decisions. 


Author(s):  
David Horsley ◽  
Bruce McKirdy

Nirex is the organisation responsible for long-term radioactive waste management in the UK. Our Mission is to provide the UK with safe, environmentally sound and publicly acceptable options for the long-term management of radioactive materials. The United Kingdom has a significant legacy of long-lived intermediate level radioactive waste. This has arisen from 50 years of investigation and exploitation of nuclear technology. Some of the waste is stored in old facilities that do not provide the standards of containment that would be incorporated in modern facilities. Also the risk to people and to the environment from the inventory in these facilities will increase with time as the structures age and degrade, increasing the chance of containment failure. There is, therefore, a need to retrieve this raw waste and process and package it to make it demonstrably safe for continued storage, pending a decision on disposal of radioactive waste. This packaging should, as far as is practicable, be compatible with the UK long-term waste management strategy. Nirex has developed its Phased Disposal Concept for intermediate and low-level radioactive waste. Based on that concept, Nirex has developed waste package specifications and carries out assessments of waste packaging proposals. For legacy wastes it may not always practicable to demonstrate full compliance with all Nirex disposal criteria. This paper describes an approach, agreed between Nirex and BNFL, for managing these wastes. The proposed approach takes account of long-term waste management issues whilst recognising the need for timely improvement of storage conditions.


1991 ◽  
Vol 14 (1) ◽  
pp. 1-7 ◽  
Author(s):  
J. M. Bowen

Any attempt to summarize 25 years of exploration for petroleum in the UK sector of the North Sea must be a daunting task. The outcome, in terms of the oil and gas fields discovered, is the subject of this volume. This introduction will attempt to outline, very briefly, some of the ups and downs of the exploration history which has led the industry to where it stands today, 25 years on (Fig. 1).When the author was at university in the early 1950s the very idea the the United Kingdom would be likely to become a significant, let alone major world producer of petroleum would have been viewed as utterly ridiculousIt is true that oil and gas indications had been encountered in wells and mines in such disparate areas as sussex, the west Midlands and the Midland Valley of Scotland and as seepages in Dorset, Lancashire and West Lothian, but these had been thoroughly investigated without the discovery of any economically significant oil or gas fields. Indeed, the only economic production at that time came from BP's small east Midlands fields based on Eakring where the first discovery had been made in 1939The first Serious attempt to explore for oil in the United Kingdom was initiated in 1918 for strategic reasons, when 11 relatively shallow wells were drilled on anticlinal features in various parts of the country. of these only one, Hardstoft-1 in Derbyshire, discovered producible oil, but attempts to follow up the discovery were unsuccessful.Exploration then


1968 ◽  
Vol 19 (3) ◽  
pp. 532
Author(s):  
André Chaineau ◽  
F. W. Paish ◽  
Andre Chaineau

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