scholarly journals Measuring MEG closer to the brain: Performance of on-scalp sensor arrays

2016 ◽  
Author(s):  
Joonas Iivanainen ◽  
Matti Stenroos ◽  
Lauri Parkkonen
Keyword(s):  
Sensor Arrays ◽  
Element Model ◽  
Magnetic Resonance Images ◽  
Field Pattern ◽  
Optically Pumped ◽  
Point Spread Functions ◽  
Field Patterns ◽  
Compartment Boundary ◽  
Volume Currents ◽  
Squid Magnetometers

AbstractOptically-pumped magnetometers (OPMs) have recently reached sensitivity levels required for magnetoencephalogra-phy (MEG). OPMs do not need cryogenics and can thus be placed within millimetres from the scalp into an array that adapts to the invidual head size and shape, thereby reducing the distance from cortical sources to the sensors. Here, we quantified the improvement in recording MEG with hypothetical on-scalp OPM arrays compared to a 306-channel state-of-the-art SQUID array (102 magnetometers and 204 planar gradiometers).We simulated OPM arrays that measured either normal (nOPM; 102 sensors), tangential (tOPM; 204 sensors), or all components (aOPM; 306 sensors) of the magnetic field. We built forward models based on magnetic resonance images of 10 adult heads; we employed a three-compartment boundary element model and distributed current dipoles evenly across the cortical mantle.Compared to the SQUID magnetometers, nOPM and tOPM yielded 7.5 and 5.3 times higher signal power, while the correlations between the field patterns of source dipoles were reduced by factors of 2.8 and 3.6, respectively. Values of the field-pattern correlations were similar across nOPM, tOPM and SQUID gradiometers. Volume currents reduced the signals of primary currents on average by 10%, 72% and 15% in nOPM, tOPM and SQUID magnetometers, respectively. The information capacities of the OPM arrays were clearly higher than that of the SQUID array. The dipole-localization accuracies of the arrays were similar while the minimum-norm-based point-spread functions were on average 2.4 and 2.5 times more spread for the SQUID array compared to nOPM and tOPM arrays, respectively.

scholarly journals Biomechanical characteristics of tibio-femoral joint after partial medial meniscectomy in different flexion angles: a finite element analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaohui Zhang ◽  
Shuo Yuan ◽  
Jun Wang ◽  
Bagen Liao ◽  
De Liang
Keyword(s):  
Finite Element ◽  
Articular Cartilage ◽  
Finite Element Model ◽  
Medial Meniscus ◽  
Lateral Meniscus ◽  
Element Model ◽  
Magnetic Resonance Images ◽  
Biomechanical Analysis ◽  
Joint Stress ◽  
Tibiofemoral Joint

Abstract Background Recent studies have pointed out that arthroscopy, the commonly-used surgical procedure for meniscal tears, may lead to an elevated risk of knee osteoarthritis (KOA). The biomechanical factors of KOA can be clarified by the biomechanical analysis after arthroscopic partial meniscectomy (APM). This study aimed to elucidate the cartilage stress and meniscus displacement of the tibiofemoral joint under flexion and rotation loads after APM. Methods A detailed finite element model of the knee bone, cartilage, meniscus, and major ligaments was established by combining computed tomography and magnetic resonance images. Vertical load and front load were applied to simulate different knee buckling angles. At the same time, by simulating flexion of different degrees and internal and external rotations, the stresses on tibiofemoral articular cartilage and meniscus displacement were evaluated. Results Generally, the contact stress on both the femoral tibial articular cartilage and the meniscus increased with the increased flexion degree. Moreover, the maximum stress on the tibial plateau gradually moved backward. The maximum position shift value of the lateral meniscus was larger than that of the medial meniscus. Conclusion Our finite element model provides a realistic three-dimensional model to evaluate the influence of different joint range of motion and rotating tibiofemoral joint stress distribution. The decreased displacement of the medial meniscus may explain the higher pressure on the knee components. These characteristics of the medial tibiofemoral joint indicate the potential biomechanical risk of knee degeneration.

scholarly journals Axial localization and tracking of self-interference nanoparticles by lateral point spread functions

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yongtao Liu ◽  
Zhiguang Zhou ◽  
Fan Wang ◽  
Günter Kewes ◽  
Shihui Wen ◽  
...  
Keyword(s):  
Mirror Image ◽  
Excitation Wavelength ◽  
Far Field ◽  
Point Spread Functions ◽  
Microscopy Imaging ◽  
Localization Accuracy ◽  
Field Patterns ◽  
Atomic Force ◽  
Point Spread ◽  
Sensing Technology

AbstractSub-diffraction limited localization of fluorescent emitters is a key goal of microscopy imaging. Here, we report that single upconversion nanoparticles, containing multiple emission centres with random orientations, can generate a series of unique, bright and position-sensitive patterns in the spatial domain when placed on top of a mirror. Supported by our numerical simulation, we attribute this effect to the sum of each single emitter’s interference with its own mirror image. As a result, this configuration generates a series of sophisticated far-field point spread functions (PSFs), e.g. in Gaussian, doughnut and archery target shapes, strongly dependent on the phase difference between the emitter and its image. In this way, the axial locations of nanoparticles are transferred into far-field patterns. We demonstrate a real-time distance sensing technology with a localization accuracy of 2.8 nm, according to the atomic force microscope (AFM) characterization values, smaller than 1/350 of the excitation wavelength.

Far-field patterns of line sources mounted between four-dielectric substrates

1992 ◽  
Vol 70 (2-3) ◽  
pp. 173-178 ◽  
Author(s):  
Ioanna Diamandi ◽  
Costas Mertzianidis ◽  
John N. Sahalos
Keyword(s):  
Remote Sensing ◽  
Line Source ◽  
Dielectric Substrate ◽  
Microstrip Antennas ◽  
Field Pattern ◽  
Substrate Thickness ◽  
Far Field ◽  
Dielectric Substrates ◽  
Field Patterns ◽  
Far Field Pattern

The far-field pattern characteristics of line sources lying between the slabs of a four-dielectric substrate configuration are presented. The patterns are calculated for several cases of the substrate thickness as well as for several line-source locations. The considerations that are made give useful applications in remote sensing and microstrip antennas.

scholarly journals Finite Element Modelling Simulated Meniscus Translocation and Deformation during Locomotion of the Equine Stifle

Animals ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 502
Author(s):  
Pasquale Zellmann ◽  
Iris Ribitsch ◽  
Stephan Handschuh ◽  
Christian Peham
Keyword(s):  
Finite Element ◽  
Lateral Meniscus ◽  
Element Model ◽  
Magnetic Resonance Images ◽  
Fem Model ◽  
Stifle Joint ◽  
Loading Patterns ◽  
Articular Cartilages ◽  
Tissue Material ◽  
Treatment Surgery

We developed a finite element model (FEM) of the equine stifle joint to identify pressure peaks and simulate translocation and deformation of the menisci. A series of sectional magnetic resonance images (1.5 T) of the stifle joint of a 23 year old Shetland pony gelding served as basis for image segmentation. Based on the 3D polygon models of femur, tibia, articular cartilages, menisci, collateral ligaments and the meniscotibial ligaments, an FEM model was generated. Tissue material properties were assigned based on data from human (Open knee(s) project) and bovine femoro-tibial joint available in the literature. The FEM model was tested across a range of motion of approximately 30°. Pressure load was overall higher in the lateral meniscus than in the medial. Accordingly, the simulation showed higher translocation and deformation in the lateral compared to the medial meniscus. The results encourage further refinement of this model for studying loading patterns on menisci and articular cartilages as well as the resulting mechanical stress in the subchondral bone (femur and tibia). A functional FEM model can not only help identify segments in the stifle which are predisposed to injury, but also to better understand the progression of certain stifle disorders, simulate treatment/surgery effects and to optimize implant/transplant properties.

scholarly journals Reconstruction of the near-field distribution in an X-ray waveguide array

2017 ◽  
Vol 50 (3) ◽  
pp. 701-711 ◽  
Author(s):  
Qi Zhong ◽  
Lars Melchior ◽  
Jichang Peng ◽  
Qiushi Huang ◽  
Zhanshan Wang ◽  
...  
Keyword(s):  
Layer Thickness ◽  
Field Distribution ◽  
Phase Retrieval ◽  
Near Field ◽  
Field Pattern ◽  
Waveguide Array ◽  
X Ray ◽  
Field Patterns ◽  
Thickness Variations ◽  
Far Field Pattern

Iterative phase retrieval has been used to reconstruct the near-field distribution behind tailored X-ray waveguide arrays, by inversion of the measured far-field pattern recorded under fully coherent conditions. It is thereby shown that multi-waveguide interference can be exploited to control the near-field distribution behind the waveguide exit. This can, for example, serve to create a secondary quasi-focal spot outside the waveguide structure. For this proof of concept, an array of seven planar Ni/C waveguides are used, with precisely varied guiding layer thickness and cladding layer thickness, as fabricated by high-precision magnetron sputtering systems. The controlled thickness variations in the range of 0.2 nm results in a desired phase shift of the different waveguide beams. Two kinds of samples, a one-dimensional waveguide array and periodic waveguide multilayers, were fabricated, each consisting of seven C layers as guiding layers and eight Ni layers as cladding layers. These are shown to yield distinctly different near-field patterns.

Source localization of S-cone and L/M-cone driven signals using silent substitution flash stimulation

2017 ◽  
Vol 62 (3) ◽  
Author(s):  
Sascha Klee ◽  
Jens Liebermann ◽  
Jens Haueisen
Keyword(s):  
Source Localization ◽  
Element Model ◽  
Selective Excitation ◽  
Dipole Localization ◽  
Silent Substitution ◽  
Grand Average ◽  
Compartment Boundary ◽  
Main Components ◽  
Flash Stimulation ◽  
Stimulation Of

AbstractThis study aimed to analyze the neuronal sources of the visual evoked potentials after flash stimulation of the S- and the L/M-cone driven channels of the visual system. For 11 volunteers a 64-channel electroencephalography (EEG) was recorded during selective excitation of both color opponent channels. Individual and grand average data were analyzed topographically. Source localization was carried out using a realistically shaped three compartment boundary element model (BEM) and a mirrored moving dipole model. We found two main components (N1, P1) in all subjects, as well as a third late component in most subjects. For these components significant latency differences (N1=33 ms, P1=22 ms; p<0.05) between both color opponent channels were found. The results showed no differences in the topography and no differences in dipole localization between both color channels. Talairach coordinates of grand averages indicated activation in area 18. Comparison of results of separately stimulated eyes revealed no differences. Our findings showed that neural processing occurs in the same areas of the visual cortex for stimuli with different spectral properties. The signals of S- and L/M-cone driven channels are transmitted in distinct pathways to the cortex. Thus, the observed latency differences might be caused by different anatomical and functional properties of these pathways.

The analysis of near and far field pattern through mode analysis and FFT in a finite periodic dielectric gratings

2015 ◽  
Vol 17 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Tae-Bong Lee ◽  
Min-Nyeon Kim
Keyword(s):  
Near Field ◽  
Bloch Wave ◽  
Wave Number ◽  
Mode Analysis ◽  
Field Pattern ◽  
Far Field ◽  
Content Type ◽  
Coupled Method ◽  
Field Patterns ◽  
Dielectric Gratings

Purpose – The purpose of this paper is to analyze far and near field emitted field patterns through more exact calculation of the modes formed in finite periodic dielectric gratings. Design/methodology/approach – For the mode calculation, equations are newly defined by applying vertical boundary condition on the assumption that transverse electric modes are generated in the structure. After finding modes, near field patterns are calculated using the wave number and coefficient of the mode. Findings – Additionally, the results from these calculations are compared with that of the rigorous-coupled method. Finally, far field patterns are derived by applying fast Fourier transform to near field patterns and also compared with the results of rigorous-coupled method. Research limitations/implications – For convenience of coordinate, we use rectangular coordinate, though the shape of radome is a hemisphere. Practical implications – In this paper, the authors derive more exact near field patterns without the assumption of infiniteness so that these results can be used practically for a making real frequency-selective structure. Originality/value – Conventional periodic finite dielectric gratings analysis has been done using Floquet–Bloch wave theory, coupled-mode, rigorous-coupled method which is based on the assumption of infiniteness of the structure.

Microstructure-Based Lasing in GaN/AlGaN Separate Confinement Heterostructures

1999 ◽  
Vol 595 ◽  
Author(s):  
S. Bidnyk ◽  
J. B. Lam ◽  
B. D. Little ◽  
G. H. Gainer ◽  
Y. H. Kwon ◽  
...  
Keyword(s):  
Strain Relaxation ◽  
Laser Diodes ◽  
Ultra Violet ◽  
Temperature Stability ◽  
Far Field ◽  
Optically Pumped ◽  
Lasing Wavelength ◽  
Field Patterns ◽  
Low Threshold ◽  
Lasing Modes

AbstractWe report on an experimental study of microstructure-based lasing in an optically pumped GaN/AlGaN separate confinement heterostructure (SCH). We achieved low-threshold ultra-violet lasing in optically pumped GaN/AlGaN separate confinement heterostructures over a wide temperature range. The spacing, directionality, and far-field patterns of the lasing modes are shown to be the result of microcavities that were naturally formed in the structures due to strain relaxation. The temperature sensitivity of the lasing wavelength was found to be twice as low as that of bulk-like GaN films. Based on these results, we discuss possibilities for the development of ultra-violet laser diodes with increased temperature stability of the emission wavelength.

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