scholarly journals Physical model of the genotype-to-phenotype map of proteins

2016 ◽  
Author(s):  
Tsvi Tlusty ◽  
Albert Libchaber ◽  
Jean-Pierre Eckmann
Keyword(s):  
Shear Band ◽  
Physical Model ◽  
Protein Function ◽  
Large Scale ◽  
Dimensional Space ◽  
Binary Sequences ◽  
Basic Question ◽  
Mechanical Basis ◽  
Low Dimensional ◽  
Scale Motion

How DNA is mapped to functional proteins is a basic question of living matter. We introduce and study a physical model of protein evolution which suggests a mechanical basis for this map. Many proteins rely on large-scale motion to function. We therefore treat protein as learning amorphous matter that evolves towards such a mechanical function: Genes are binary sequences that encode the connectivity of the amino acid network that makes a protein. The gene is evolved until the network forms a shear band across the protein, which allows for long-range, soft modes required for protein function. The evolution reduces the high-dimensional sequence space to a low-dimensional space of mechanical modes, in accord with the observed dimensional reduction between genotype and phenotype of proteins. Spectral analysis of the space of 106 solutions shows a strong correspondence between localization around the shear band of both mechanical modes and the sequence structure. Specifically, our model shows how mutations are correlated among amino acids whose interactions determine the functional mode.PACS numbers: 87.14.E-, 87.15.-v, 87.10.-e

scholarly journals A theory of multineuronal dimensionality, dynamics and measurement

2017 ◽  
Author(s):  
Peiran Gao ◽  
Eric Trautmann ◽  
Byron Yu ◽  
Gopal Santhanam ◽  
Stephen Ryu ◽  
...  
Keyword(s):  
Experimental Design ◽  
Large Scale ◽  
Task Complexity ◽  
Dimensional Space ◽  
Neural Dynamics ◽  
Firing Rates ◽  
Control Behavior ◽  
Reduction Methods ◽  
Low Dimensional

AbstractIn many experiments, neuroscientists tightly control behavior, record many trials, and obtain trial-averaged firing rates from hundreds of neurons in circuits containing billions of behaviorally relevant neurons. Di-mensionality reduction methods reveal a striking simplicity underlying such multi-neuronal data: they can be reduced to a low-dimensional space, and the resulting neural trajectories in this space yield a remarkably insightful dynamical portrait of circuit computation. This simplicity raises profound and timely conceptual questions. What are its origins and its implications for the complexity of neural dynamics? How would the situation change if we recorded more neurons? When, if at all, can we trust dynamical portraits obtained from measuring an infinitesimal fraction of task relevant neurons? We present a theory that answers these questions, and test it using physiological recordings from reaching monkeys. This theory reveals conceptual insights into how task complexity governs both neural dimensionality and accurate recovery of dynamic portraits, thereby providing quantitative guidelines for future large-scale experimental design.

scholarly journals A learned embedding for efficient joint analysis of millions of mass spectra

2018 ◽  
Author(s):  
Damon H. May ◽  
Jeffrey Bilmes ◽  
William S. Noble
Keyword(s):  
Mass Spectra ◽  
Large Scale ◽  
Dimensional Space ◽  
Software Implementation ◽  
Mass Spectrometry Data ◽  
Joint Analysis ◽  
Clustering Methods ◽  
Peptide Mass ◽  
Public Repositories ◽  
Low Dimensional

AbstractDespite an explosion of data in public repositories, peptide mass spectra are usually analyzed by each laboratory in isolation, treating each experiment as if it has no relationship to any others. This approach fails to exploit the wealth of existing, previously analyzed mass spectrometry data. Others have jointly analyzed many mass spectra, often using clustering. However, mass spectra are not necessarily best summarized as clusters, and although new spectra can be added to existing clusters, clustering methods previously applied to mass spectra do not allow new clusters to be defined without completely re-clustering. As an alternative, we propose to train a deep neural network, called “GLEAMS,” to learn an embedding of spectra into a low-dimensional space in which spectra generated by the same peptide are close to one another. We demonstrate empirically the utility of this learned embedding by propagating annotations from labeled to unlabeled spectra. We further use GLEAMS to detect groups of unidentified, proximal spectra representing the same peptide, and we show how to use these spectral communities to reveal misidentified spectra and to characterize frequently observed but consistently unidentified molecular species. We provide a software implementation of our approach, along with a tool to quickly embed additional spectra using a pre-trained model, to facilitate large-scale analyses.

scholarly journals Context-Aware Content Generation for Virtual Environments

2016 ◽  
Author(s):  
Andrew Brock ◽  
Theodore Lim ◽  
J. M. Ritchie ◽  
Nick Weston
Keyword(s):  
Large Scale ◽  
Dimensional Space ◽  
Context Aware ◽  
3 Dimensional ◽  
Latent Space ◽  
Variational Autoencoder ◽  
Computationally Intensive ◽  
Expert Input ◽  
Low Dimensional ◽  
Content Generation

Large scale scene generation is a computationally intensive operation, and added complexities arise when dynamic content generation is required. We propose a system capable of generating virtual content from non-expert input. The proposed system uses a 3-dimensional variational autoencoder to interactively generate new virtual objects by interpolating between extant objects in a learned low-dimensional space, as well as by randomly sampling in that space. We present an interface that allows a user to intuitively explore the latent manifold, taking advantage of the network’s ability to perform algebra in the latent space to help infer context and generalize to previously unseen inputs.

scholarly journals Community Detection Based on DeepWalk Model in Large-Scale Networks

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Yunfang Chen ◽  
Li Wang ◽  
Dehao Qi ◽  
Tinghuai Ma ◽  
Wei Zhang
Keyword(s):  
Community Structure ◽  
Community Detection ◽  
Large Scale ◽  
Dimensional Space ◽  
Complex Structure ◽  
Gaussian Mixture ◽  
Detection Algorithm ◽  
Detection Methods ◽  
Large Scale Networks ◽  
Low Dimensional

The large-scale and complex structure of real networks brings enormous challenges to traditional community detection methods. In order to detect community structure in large-scale networks more accurately and efficiently, we propose a community detection algorithm based on the network embedding representation method. Firstly, in order to solve the scarce problem of network data, this paper uses the DeepWalk model to embed a high-dimensional network into low-dimensional space with topology information. Then, low-dimensional data are processed, with each node treated as a sample and each dimension of the node as a feature. Finally, samples are fed into a Gaussian mixture model (GMM), and in order to automatically learn the number of communities, variational inference is introduced into GMM. Experimental results on the DBLP dataset show that the model method of this paper can more effectively discover the communities in large-scale networks. By further analyzing the excavated community structure, the organizational characteristics within the community are better revealed.

scholarly journals SIMNETS: a computationally efficient and scalable framework for identifying sub-networks of functionally similar neurons

2018 ◽  
Author(s):  
Jacqueline B. Hynes ◽  
David M. Brandman ◽  
Jonas B. Zimmerman ◽  
John P. Donoghue ◽  
Carlos E. Vargas-Irwin
Keyword(s):  
Large Scale ◽  
Dimensional Space ◽  
Ground Truth ◽  
Computationally Efficient ◽  
Intrinsic Geometry ◽  
Experimental Conditions ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Technological Advances ◽  
Low Dimensional

AbstractRecent technological advances have made it possible to simultaneously record the activity of thousands of individual neurons in the cortex of awake behaving animals. However, the comparatively slower development of analytical tools capable of handling the scale and complexity of large-scale recordings is a growing problem for the field of neuroscience. We present the Similarity Networks (SIMNETS) algorithm: a computationally efficient and scalable method for identifying and visualizing sub-networks of functionally similar neurons within larger simultaneously recorded ensembles. While traditional approaches tend to group neurons according to the statistical similarities of inter-neuron spike patterns, our approach begins by mathematically capturing the intrinsic relationship between the spike train outputs of each neuron across experimental conditions, before any comparisons are made between neurons. This strategy estimates the intrinsic geometry of each neuron’s output space, allowing us to capture the information processing properties of each neuron in a common format that is easily compared between neurons. Dimensionality reduction tools are then used to map high-dimensional neuron similarity vectors into a low-dimensional space where functional groupings are identified using clustering and statistical techniques. SIMNETS makes minimal assumptions about single neuron encoding properties; is efficient enough to run on consumer-grade hardware (100 neurons < 4s run-time); and has a computational complexity that scales near-linearly with neuron number. These properties make SIMNETS well-suited for examining large networks of neurons during complex behaviors. We validate the ability of our approach for detecting statistically and physiologically meaningful functional groupings in a population of synthetic neurons with known ground-truth, as well three publicly available datasets of ensemble recordings from primate primary visual and motor cortex and the rat hippocampal CA1 region.

scholarly journals Parameter tuning is a key part of dimensionality reduction via deep variational autoencoders for single cell RNA transcriptomics

2018 ◽  
Author(s):  
Qiwen Hu ◽  
Casey S. Greene
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Gene Expression Data ◽  
Large Scale ◽  
Dimensional Space ◽  
Parameter Tuning ◽  
Generative Models ◽  
Underlying Structure ◽  
Expression Data ◽  
Low Dimensional

Single-cell RNA sequencing (scRNA-seq) is a powerful tool to profile the transcriptomes of a large number of individual cells at a high resolution. These data usually contain measurements of gene expression for many genes in thousands or tens of thousands of cells, though some datasets now reach the million-cell mark. Projecting high-dimensional scRNA-seq data into a low dimensional space aids downstream analysis and data visualization. Many recent preprints accomplish this using variational autoencoders (VAE), generative models that learn underlying structure of data by compress it into a constrained, low dimensional space. The low dimensional spaces generated by VAEs have revealed complex patterns and novel biological signals from large-scale gene expression data and drug response predictions. Here, we evaluate a simple VAE approach for gene expression data, Tybalt, by training and measuring its performance on sets of simulated scRNA-seq data. We find a number of counter-intuitive performance features: i.e., deeper neural networks can struggle when datasets contain more observations under some parameter configurations. We show that these methods are highly sensitive to parameter tuning: when tuned, the performance of the Tybalt model, which was not optimized for scRNA-seq data, outperforms other popular dimension reduction approaches – PCA, ZIFA, UMAP and t-SNE. On the other hand, without tuning performance can also be remarkably poor on the same data. Our results should discourage authors and reviewers from relying on self-reported performance comparisons to evaluate the relative value of contributions in this area at this time. Instead, we recommend that attempts to compare or benchmark autoencoder methods for scRNA-seq data be performed by disinterested third parties or by methods developers only on unseen benchmark data that are provided to all participants simultaneously because the potential for performance differences due to unequal parameter tuning is so high.

scholarly journals Finding Approximate POMDP solutions Through Belief Compression

2005 ◽  
Vol 23 ◽  
pp. 1-40 ◽  
Author(s):  
N. Roy ◽  
G. Gordon ◽  
S. Thrun
Keyword(s):  
Optimal Policy ◽  
Large Scale ◽  
Value Function ◽  
Dimensional Space ◽  
Good Control ◽  
Dimensional Subspace ◽  
Mobile Robot Navigation ◽  
High Dimensional ◽  
Markov Decision ◽  
Low Dimensional

Standard value function approaches to finding policies for Partially Observable Markov Decision Processes (POMDPs) are generally considered to be intractable for large models. The intractability of these algorithms is to a large extent a consequence of computing an exact, optimal policy over the entire belief space. However, in real-world POMDP problems, computing the optimal policy for the full belief space is often unnecessary for good control even for problems with complicated policy classes. The beliefs experienced by the controller often lie near a structured, low-dimensional subspace embedded in the high-dimensional belief space. Finding a good approximation to the optimal value function for only this subspace can be much easier than computing the full value function. We introduce a new method for solving large-scale POMDPs by reducing the dimensionality of the belief space. We use Exponential family Principal Components Analysis (Collins, Dasgupta & Schapire, 2002) to represent sparse, high-dimensional belief spaces using small sets of learned features of the belief state. We then plan only in terms of the low-dimensional belief features. By planning in this low-dimensional space, we can find policies for POMDP models that are orders of magnitude larger than models that can be handled by conventional techniques. We demonstrate the use of this algorithm on a synthetic problem and on mobile robot navigation tasks.

scholarly journals Drug-Drug Interactions Prediction via Knowledge Graph and Text Embedding (Preprint)

2021 ◽  
Author(s):  
Meng Wang ◽  
Haofen Wang ◽  
Xing Liu ◽  
Xinyu Ma ◽  
Beilun Wang
Keyword(s):  
Drug Interactions ◽  
Large Scale ◽  
Dimensional Space ◽  
Knowledge Bases ◽  
Knowledge Graph ◽  
Drug Knowledge ◽  
Real World Datasets ◽  
Low Dimensional ◽  
Different Sources ◽  
Opening Up

UNSTRUCTURED Minimizing adverse reactions caused by drug-drug interactions has always been a momentous research topic in clinical pharmacology. Detecting all possible interactions through clinical studies before a drug is released to the market is a demanding task. The power of big data is opening up new approaches to discover various drug-drug interactions. However, these discoveries contain a huge amount of noise and provide knowledge bases far from complete and trustworthy ones to be utilized. Most existing studies focus on predicting binary drug-drug interactions between drug pairs and ignore other interactions. In this paper, we propose a novel framework, called PRD, to predict drug-drug interactions. The framework uses the graph embedding that can overcome data incompleteness and sparsity issues to achieve multiple DDI label prediction. First, a large-scale drug knowledge graph is generated from different sources. Then, the knowledge graph is embedded with comprehensive biomedical text into a common low dimensional space. Finally, the learned embeddings are used to efficiently compute rich DDI information through a link prediction process. To validate the effectiveness of the proposed framework, extensive experiments were conducted on real-world datasets. The results demonstrate that our model outperforms several state-of-the-art baseline methods in terms of capability and accuracy.

Large-scale Motion of Solar Filaments

2000 ◽  
Vol 179 ◽  
pp. 205-208
Author(s):  
Pavel Ambrož ◽  
Alfred Schroll
Keyword(s):  
Magnetic Flux ◽  
Proper Motion ◽  
Time Scale ◽  
Large Scale ◽  
Accuracy Of Measurements ◽  
Solar Filaments ◽  
General Movement ◽  
Scale Motion ◽  
Velocity Scatter

AbstractPrecise measurements of heliographic position of solar filaments were used for determination of the proper motion of solar filaments on the time-scale of days. The filaments have a tendency to make a shaking or waving of the external structure and to make a general movement of whole filament body, coinciding with the transport of the magnetic flux in the photosphere. The velocity scatter of individual measured points is about one order higher than the accuracy of measurements.

A Survey of Network Embedding for Drug Analysis and Prediction

2020 ◽  
Vol 21 ◽  
Author(s):  
Zhixian Liu ◽  
Qingfeng Chen ◽  
Wei Lan ◽  
Jiahai Liang ◽  
Yiping Pheobe Chen ◽  
...  
Keyword(s):  
Deep Learning ◽  
Protein Function ◽  
Dimensional Space ◽  
Auxiliary Information ◽  
Matrix Decomposition ◽  
Drug Analysis ◽  
Machine Learning Algorithms ◽  
Superior Performance ◽  
Network Embedding ◽  
Similarity Estimation

: Traditional network-based computational methods have shown good results in drug analysis and prediction. However, these methods are time consuming and lack universality, and it is difficult to exploit the auxiliary information of nodes and edges. Network embedding provides a promising way for alleviating the above problems by transforming network into a low-dimensional space while preserving network structure and auxiliary information. This thus facilitates the application of machine learning algorithms for subsequent processing. Network embedding has been introduced into drug analysis and prediction in the last few years, and has shown superior performance over traditional methods. However, there is no systematic review of this issue. This article offers a comprehensive survey of the primary network embedding methods and their applications in drug analysis and prediction. The network embedding technologies applied in homogeneous network and heterogeneous network are investigated and compared, including matrix decomposition, random walk, and deep learning. Especially, the Graph neural network (GNN) methods in deep learning are highlighted. Further, the applications of network embedding in drug similarity estimation, drug-target interaction prediction, adverse drug reactions prediction, protein function and therapeutic peptides prediction are discussed. Several future potential research directions are also discussed.

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