scholarly journals The next 20 years of genome research

2015 ◽  
Author(s):  
Michael Schatz
Keyword(s):  
Human Genetics ◽  
Genome Research ◽  
Real Potential ◽  
Human Genomes ◽  
The Future ◽  
Future Technologies ◽  
Quantitative Approaches

The last 20 years have been a remarkable era for biology and medicine. One of the most significant achievements has been the sequencing of the first human genomes, which has laid the foundation for profound insights into human genetics, the intricacies of regulation and development, and the forces of evolution. Incredibly, as we look into the future over the next 20 years, we see the very real potential for sequencing more than one billion genomes, bringing with it even deeper insights into human genetics as well as the genetics of millions of other species on the planet. Realizing this great potential, though, will only be achieved through the integration and development of highly scalable computational and quantitative approaches can keep pace with the rapid improvements to biotechnology. In this perspective, we aim to chart out these future technologies, anticipate the major themes of research, and call out the challenges ahead. One of the largest shifts will be in the training used to prepare the class of 2035 for their highly interdisciplinary world.

Intuitive, digitale Strukturlayoutplanung*/Intuitive digital planning of structure layouts – Overcoming the challenges of disruptive production programs in the automotive industry

2018 ◽  
Vol 108 (09) ◽  
pp. 611-616
Author(s):  
S. F. Schäfer ◽  
U. Bracht
Keyword(s):  
Automotive Industry ◽  
New Technologies ◽  
Know How ◽  
Digital Planning ◽  
The Future ◽  
Factory Of The Future ◽  
Future Technologies ◽  
The Impact

Zukünftige Antriebstechnologien sowie neue Fabrik- und Logistikkonzepte verändern die Rahmenbedingungen der Automobilproduktion grundlegend. Schon heute muss die Strukturlayoutplanung Innovationen und Unsicherheiten in Form von mehr Varianten, abgestimmt in sehr kurzer Zeit, durch die Einbeziehung von weiteren Know-how-Trägern berücksichtigen. Neue Herausforderungen, wie die Planung der Batteriefertigungen, müssen schnell und intuitiv gelöst werden. Einen Beitrag dafür liefert dieser Artikel.   Future technologies in automotive mobility as well as new factory and logistic concepts are changing the framework in car production. Innovations and uncertainties (e. g. the impact of new technologies) have to be taken in consideration for the factory of the future. New tasks, such as planning the assembly of batteries, need to be solved fast and intuitively. This paper presents an approach to this topic.

Are Central Bank Digital Currencies the Future of Cash?

ITNOW ◽  
2021 ◽  
Vol 63 (3) ◽  
pp. 24-25
Author(s):  
William Lovell
Keyword(s):  
Central Bank ◽  
Bank Of England ◽  
The Future ◽  
Future Technologies

Abstract William Lovell, Head of Future Technologies at the Bank of England, explores how central bank digital currencies might change money, the problems of a cashless society and how he’s keeping bar staff guessing.

Thoughts on the Future of Human Genetics

1969 ◽  
Vol 53 (4) ◽  
pp. 1001-1011 ◽  
Author(s):  
James V. Neel
Keyword(s):  
Human Genetics ◽  
The Future

scholarly journals svtools: population-scale analysis of structural variation

2019 ◽  
Vol 35 (22) ◽  
pp. 4782-4787 ◽  
Author(s):  
David E Larson ◽  
Haley J Abel ◽  
Colby Chiang ◽  
Abhijit Badve ◽  
Indraniel Das ◽  
...  
Keyword(s):  
Large Scale ◽  
Structural Variation ◽  
Human Genetics ◽  
Mobile Element ◽  
Supplementary Information ◽  
Joint Analysis ◽  
Human Populations ◽  
Scale Analysis ◽  
Human Genomes ◽  
Variant Detection

Abstract Summary Large-scale human genetics studies are now employing whole genome sequencing with the goal of conducting comprehensive trait mapping analyses of all forms of genome variation. However, methods for structural variation (SV) analysis have lagged far behind those for smaller scale variants, and there is an urgent need to develop more efficient tools that scale to the size of human populations. Here, we present a fast and highly scalable software toolkit (svtools) and cloud-based pipeline for assembling high quality SV maps—including deletions, duplications, mobile element insertions, inversions and other rearrangements—in many thousands of human genomes. We show that this pipeline achieves similar variant detection performance to established per-sample methods (e.g. LUMPY), while providing fast and affordable joint analysis at the scale of ≥100 000 genomes. These tools will help enable the next generation of human genetics studies. Availability and implementation svtools is implemented in Python and freely available (MIT) from https://github.com/hall-lab/svtools. Supplementary information Supplementary data are available at Bioinformatics online.

Visions of the future: technologies to succeed

2001 ◽  
Vol 40 (2) ◽  
pp. 111-117
Author(s):  
J. Goldberg ◽  
J. Haddon
Keyword(s):  
The Future ◽  
Future Technologies

The Importance of Attitudes toward and Understanding of Disability and Science in the Age of Genetics

2007 ◽  
Vol 32 (3) ◽  
pp. 190-206 ◽  
Author(s):  
Matthew J. Stowe ◽  
H. Rutherford Turnbull ◽  
Ray Pence ◽  
Jennifer Rack ◽  
Suzanne Schrandt ◽  
...  
Keyword(s):  
Human Genetics ◽  
Genetic Research ◽  
Early 20Th Century ◽  
Genome Research ◽  
Community Members ◽  
Attitudes Toward Disability ◽  
Negative Attitudes ◽  
Perceptions Of Disability ◽  
National Human

This article reports concerns among disability community members that the implications of genetic research will be driven by mistaken beliefs about genetics and negative attitudes toward disability as identified in a qualitative study funded by the National Human Genome Research Institute. In addition to reporting the nature and the context of disability community concerns related to perceptions of disability and of human genetics, the authors discuss the historic role of attitudes toward disability and science in popularizing eugenics in early 20th century America as evidence of the seriousness of these concerns.

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