scholarly journals Slowing of Event-Related Potentials in Primary Progressive Aphasia. A case report

2009 ◽  
Vol 9 ◽  
pp. 633-638 ◽  
Author(s):  
Salvatore Giaquinto ◽  
Francesca Ranghi
Keyword(s):  
Word Recognition ◽  
Cognitive Abilities ◽  
Single Case ◽  
Electrical Potential ◽  
Primary Progressive Aphasia ◽  
Event Related Potentials ◽  
Control Group ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Related Potentials

Primary Progressive Aphasia (PPA) is a rare and insidious language impairment that worsens over time. It belongs to the group of fronto–temporal dementias. This study was aimed at assessing the role of speed of cognitive abilities, such as word recognition, in PPA. The design is a single-case, longitudinal study. A male patient suffering from PPA was enrolled and 15 healthy older adults were the control group. An event-related electrical potential connected with word recognition, namely the N400, was delayed by 200 msec at baseline compared to healthy controls and progressively deteriorated. One year later, the delay was greater and two years later the potential had disappeared. Reduced speed of processing is an early pathological factor that negatively affecting higher cognitive functions in APP. Event–related electrical potentials are recommended in the field of aphasia and cognitive decline. They permit observation of a speed decline in higher cognitive abilities, when pathological changes at a central level begin and language comprehension seems to be unaffected.

Language and Speech Markers of Primary Progressive Aphasia: A Systematic Review

2020 ◽  
Vol 29 (4) ◽  
pp. 2206-2225
Author(s):  
Jara Stalpaert ◽  
Elissa-Marie Cocquyt ◽  
Yana Criel ◽  
Lieselot Segers ◽  
Marijke Miatton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Primary Progressive Aphasia ◽  
Event Related Potentials ◽  
Diagnostic Methods ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Topographical Distribution ◽  
Electrophysiological Studies ◽  
Related Potentials ◽  
Semantic Variant

Purpose This systematic review aimed to establish language and speech markers to support the clinical diagnosis of primary progressive aphasia (PPA) and its clinical phenotypes. Our first objective was to identify behavioral language and speech markers of early-stage PPA. Our second objective was to identify the electrophysiological correlates of the language and speech characteristics in PPA. Method The databases MEDLINE, Web of Science, and Embase were searched for relevant articles. To identify behavioral markers, the initial subjective complaints and the language and speech deficits detected during the initial diagnostic evaluation were summarized for PPA in general and each clinical variant according to the 2011 consensus diagnostic criteria (nonfluent variant [NFV], semantic variant, and logopenic variant [LV]). To identify electrophysiological markers, the studies in which event-related potentials (ERPs) were elicited by a language or speech paradigm in patients with PPA were included. Results In total, 114 relevant studies were identified, including 110 behavioral studies and only four electrophysiological studies. This review suggests that patients with the semantic variant could be accurately differentiated from the NFV and LV in the initial stages based on the consensus criteria. Nonetheless, the early differentiation between the NFV and LV is not straightforward. In the four electrophysiological studies, differences in the latency, amplitude, and topographical distribution of the semantic N400 component were found between patients with PPA and healthy controls. Conclusions To accurately differentiate the NFV from the LV, it could be important to assess the language and speech degeneration by more specific assessments and by more objective diagnostic methods that offer insights into the language-related processes. Electrophysiological markers of PPA were not identified in this review due to the low number of studies that investigated language-related ERPs. More controlled ERP studies in larger patient cohorts are needed to investigate the diagnostic applicability of language-related ERPs in PPA. Supplemental Material https://doi.org/10.23641/asha.12798080

scholarly journals Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

2011 ◽  
Vol 69 (3) ◽  
pp. 446-451 ◽  
Author(s):  
Fábio Pascotto de Oliveira ◽  
Jaderson Costa da Costa ◽  
Sabine Possa Marroni ◽  
Ana Maria Marques da Silva ◽  
Sthefanie Hansen Barreiro ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Cognitive Deficits ◽  
Diffusion Tensor ◽  
Primary Progressive Aphasia ◽  
Control Group ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Language Deficit ◽  
Volume Method ◽  
Diffusion Tensor Imaging Dti

There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA). OBJECTIVE: Identify by means of diffusion tensor imaging (DTI) and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume. METHOD: Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers. RESULTS: There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients. CONCLUSION: Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas.

scholarly journals The Effect of Word Retrieval Therapy in Primary Progressive Aphasia: A Single-Case Study

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Salime Jafari ◽  
Ahmad Reza Khatoonabadi ◽  
Maryam Noroozian ◽  
Azar Mehri ◽  
Hassan Ashayeri ◽  
...  
Keyword(s):  
Single Case ◽  
Primary Progressive Aphasia ◽  
Word Retrieval ◽  
Single Case Study ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Thinking Outside the Stroke: Treating Primary Progressive Aphasia (PPA)

2012 ◽  
Vol 17 (2) ◽  
pp. 37-49 ◽  
Author(s):  
Becky Khayum ◽  
Christina Wieneke ◽  
Emily Rogalski ◽  
Jaimie Robinson ◽  
Mary O’Hara
Keyword(s):  
Quality Of Life ◽  
Brain Injury ◽  
Cognitive Abilities ◽  
Speech Therapy ◽  
Primary Progressive Aphasia ◽  
Supportive Services ◽  
Language Abilities ◽  
Progressive Aphasia ◽  
Primary Progressive

In this article, we explore the symptoms, cause, treatment potential, and supportive services for individuals diagnosed with Primary Progressive Aphasia (PPA). Although it is possible to regain certain cognitive abilities with stroke or brain injury, in PPA, language abilities worsen and other symptoms emerge with time, shortening the lifespan. The goal of speech therapy for PPA is not to regain lost language, but rather to maximize communication for as long as possible. In this article, we offer information and tools for speech-language pathologists to help people living with PPA achieve these goals and improve overall quality of life.

scholarly journals Acquired surface dysgraphia and dyslexia in the semantic variant of primary progressive aphasia: a single-case study in Spanish

Aphasiology ◽  
2020 ◽  
pp. 1-22
Author(s):  
Florentina Morello García ◽  
Micaela Difalcis ◽  
Samanta Leiva ◽  
Ricardo F. Allegri ◽  
Aldo R. Ferreres
Keyword(s):  
Single Case ◽  
Primary Progressive Aphasia ◽  
Single Case Study ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Semantic Variant

scholarly journals Treating lexical retrieval using letter fluency and tDCS in primary progressive aphasia: a single-case study

Aphasiology ◽  
2021 ◽  
pp. 1-27
Author(s):  
Vânia de Aguiar ◽  
Adrià Rofes ◽  
Haley Wendt ◽  
Bronte N. Ficek ◽  
Kimberly Webster ◽  
...  
Keyword(s):  
Single Case ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Single Case Study ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Embedding Aphasia-Modified Cognitive Behavioral Therapy in Script Training for Primary Progressive Aphasia: A Single-Case Pilot Study

2021 ◽  
pp. 1-16
Author(s):  
Kristin M. Schaffer ◽  
William S. Evans ◽  
Christina D. Dutcher ◽  
Christina Philburn ◽  
Maya L. Henry
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Single Case ◽  
Primary Progressive Aphasia ◽  
Phenomenological Analysis ◽  
Post Treatment ◽  
Cognitive Behavioral ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Script Training

Purpose This study sought to determine the initial feasibility and benefit of a novel intervention that combines speech-language treatment with counseling treatment for an individual with the nonfluent/agrammatic variant of primary progressive aphasia (PPA). Method Using a single-case experimental design, we evaluated the utility of modified script training paired with aphasia-modified cognitive behavioral therapy. The study employed a multiple baseline design across scripts for the primary linguistic outcome measure and a mixed methods approach for analyzing counseling outcomes. Psychosocial and communicative functioning scales were administered in conjunction with a phenomenological analysis of semi-structured interviews. Results The participant completed all study phases and participated in all treatment components. She met the criterion of 90% correct, intelligible scripted words on all trained scripts through 12 months post-treatment. Treatment outcomes were comparable to a comparison cohort that received script training without counseling ( Henry et al., 2018 ). At post-treatment, the participant demonstrated stability or improvement on all measures of psychosocial and communicative functioning, with stability documented on seven out of 11 scales at follow-ups through 12 months post-treatment. A phenomenological analysis revealed pervasive themes of loss and resilience at both time points, and emerging themes of positive self-perception, sense of agency, and emotional attunement following treatment. Conclusions Results indicate that script training with aphasia-modified cognitive behavioral therapy is a feasible treatment for an individual with the nonfluent/agrammatic variant of PPA, with immediate and lasting benefits to speech-language production and psychosocial functioning. These findings are the first to support the integration of personal adjustment counseling techniques within a speech-language treatment paradigm for PPA. Supplemental Material https://doi.org/10.23641/asha.14925330

scholarly journals The Nonverbal Processing of Actions Is an Area of Relative Strength in the Semantic Variant of Primary Progressive Aphasia

2020 ◽  
Vol 63 (2) ◽  
pp. 569-584 ◽  
Author(s):  
Noémie Auclair-Ouellet ◽  
Marion Fossard ◽  
Joël Macoir ◽  
Robert Laforce
Keyword(s):  
Primary Progressive Aphasia ◽  
Relative Strength ◽  
Control Group ◽  
Progressive Aphasia ◽  
Assessment Task ◽  
Primary Progressive ◽  
Action Naming ◽  
Significant Difference ◽  
Semantic Variant ◽  
Better Than

Purpose Better performance for actions compared to objects has been reported in the semantic variant of primary progressive aphasia (svPPA). This study investigated the influence of the assessment task (naming, semantic picture matching) over the dissociation between objects and actions. Method Ten individuals with svPPA and 17 matched controls completed object and action naming tests, and object and action semantic picture matching tests. Performance was compared between the svPPA and control groups, within the svPPA group, and for each participant with svPPA versus the control group individually. Results Compared to controls, participants with svPPA were impaired on object and action naming, and object and action semantic picture matching. As a group, participants with svPPA had an advantage for actions over objects and for semantic picture matching tests over naming tests. Eight participants had a better performance for actions compared to objects in naming, with three showing a significant difference. Nine participants had a better performance for actions compared to objects in semantic picture matching, with six showing a significant difference. For objects, semantic picture matching was better than naming in nine participants, with five showing a significant difference. For actions, semantic picture matching was better than naming in all 10 participants, with nine showing a significant difference. Conclusion The nonverbal processing of actions, as assessed with a semantic picture matching test, is an area of relative strength in svPPA. Clinical implications for assessment planning and interpretation and theoretical implications for current models of semantic cognition are discussed.

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