scholarly journals The Efficacy of Treatment of Different Intervention Programs for Patellofemoral Pain Syndrome–A Single Blinded Randomized Clinical Trial. Pilot Study

2007 ◽  
Vol 7 ◽  
pp. 1256-1262 ◽  
Author(s):  
Feazadeh Avraham ◽  
Saposhnik Aviv ◽  
Pnina Ya'akobi ◽  
Hava Faran ◽  
Zilla Fisher ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Pain Syndrome ◽  
Rehabilitation Program ◽  
Group Iii ◽  
Rehabilitation Programs ◽  
Knee Rehabilitation ◽  
Group I ◽  
Similar Beneficial Effect ◽  
And Function ◽  
Joint Evaluation

Patello-femoral pain syndrome (PFPS) is a common knee joint disability. The integration of hip soft tissue regimens are not always emphasized, although current literature implies that there is a significant relationship between the two and there is a lack of randomized clinical trials to substantiate this relationship in clinical practice. A randomized controlled assessor blinded trial was designed to explore different rehabilitation programs related to PFPS. The study was conducted at RAZIEL institute of physical therapy, Netania, Israel with a total of 30 consecutive patients (mean age 35y), diagnosed with PFPS. All patients were randomly allocated into 3 groups. Group I conventional knee rehabilitation program. Included quadriceps strengthening and Trans Electric Neuromuscular Stimulation (TENS). Group II hip oriented rehabilitation program. included stretching, Hip external rotators strengthening and TENS. Group III a combination of the two above programs. Pain and function were documented on initial of the program and again 3 weeks later, on the completion. Pain was assessed by a numeric visual analogue scale (VAS); function was assessed by Patello-femoral joint evaluation scale (PFJES) (0-100 points). At end of trial, all groups showed significant improvements in VAS and PFJES (p<0.0001); these improvements did not vary significantly between the 3 groups. The conclusions were that the explored different rehabilitation programs showed a similar beneficial effect.

scholarly journals The Effectiveness Of Quadriceps Strengthening Exercises Combined With Neuromuscular Electrical Stimulation on Patellofemoral Pain Syndrome

2017 ◽  
Vol 5 (2_suppl2) ◽  
pp. 2325967117S0010
Author(s):  
Sezen Karabörklü Argut ◽  
Nilgün Türker ◽  
Derya Çelik ◽  
Önder İsmet Kılıçoğlu
Keyword(s):  
Electrical Stimulation ◽  
Muscle Strength ◽  
Neuromuscular Electrical Stimulation ◽  
Pain Syndrome ◽  
Quadriceps Strength ◽  
Patellofemoral Pain ◽  
Group I ◽  
Strengthening Exercises ◽  
Group Ii ◽  
And Function

Objective: The weakness of the quadriceps strength in patellofemoral pain syndrome (PFPS) is very evident. Therefore, quadriceps strengthening exercises are very important part of the rehabilitation program. Neuromuscular Electrical Stimulation (NMES) is considered one of the methods for increasing quadriceps muscle strength. To evaluate the effectiveness of combined NMES and strengthening exercises to improve the recovery of quadriceps strength and function in patients with PFPS. Methods: This study was planned as a randomized controlled pilot study. A total of 27 patients (mean age=38.9±10.8 years, range=20-60 years; 16 females) with PFPS were assessed and randomly assigned into 2 groups. Group I received a standard program (quadriceps strengthening, hip strengthening and hamstring stretching) and NMES combined with quadriceps strengthening exercises simultaneously. Group II received the same standard program without NMES. Both groups were enrolled 3 times per week for 40 minutes per day in 6 weeks. Patients were assessed at the baseline, 3 rd, 6th, and 12th weeks of treatment. Quadriceps strength was evaluated by isokinetic dynamometer. The range of motion at testing was set between 0 for extension to 90 for flexion. The test was performed at 60 degrees/sn and concentric maximum peak torque value was recorded. Kujala and Lysholm scores were used for functional assessments. The data were analyzed using the SPSS 20.0. Shapiro-Wilk test was used to assess the distribution of data. The changes in dependent variables before treatment, 3 rd, 6th, and 12th weeks were analyzed using a 2 by 4 mixed-model analysis of variance (ANOVA). Pairwise comparisons with paired t test were used to determine whether the Group I or Group II, has changed over time. An intention- to- treat analysis was performed to impute values for missing data. An alpha level of 0.05 was established. Results: The study was completed with 20 patients. Group I (n=10; mean age=39.4±8.5 years; 7 females) and group II (n=10; mean age=43.2±11.7 years; 5 females) had no differences in pre-operative measures (p>.05). There was significant improvements in within groups statistics of all parameters for both groups (p<.05). No differences in quadriceps strength, Kujala and Lysholm scores between groups were found at the different time points (F= 0.86; p = 0.12, F=0,001; p =0.97, F=0.12; p=0.73, respectively) Conclusion: NMES combined with quadriceps strengthening exercises has no additional effect on PFPS patients’ on muscle strength and function. When considering these results, we believe that there is no need to continue the study in progress. [Table: see text]

scholarly journals Modern aspects of social protection of combatants depending on the severity of disability

2020 ◽  
pp. 35-40
Author(s):  
N. M. Bieliaieva ◽  
O. B. Yavorovenko ◽  
I. V. Kurylenko ◽  
L. V. Prysiazhniuk ◽  
O. V. Dziuniak ◽  
...  
Keyword(s):  
Medical Rehabilitation ◽  
Rehabilitation Services ◽  
Persons With Disabilities ◽  
Rehabilitation Process ◽  
Group Iii ◽  
Rehabilitation Programs ◽  
Social Rehabilitation ◽  
Group I ◽  
Severity Of Disability ◽  
Rehabilitation Measures

The urgency of the problem is due to the significant increase in recent years in the number of young and middle-aged people who have passed the war, the need to develop adequate measures of social assistance and protection. An important task in the organization of the rehabilitation process is to determine the structure of the needs of servicemen with disabilities in various types of medical and social care and the development of individual rehabilitation programs (IRP) based on them. The purpose of the study: to determine the structure of the needs of servicemen with disabilities in medical and social rehabilitation depending on the severity of disability. Statistical data from 25 administrative territories of Ukraine for 2018 are analyzed, the needs of participants of military service with disabilities in medical and social rehabilitation measures, their structure are calculated. The data of the information base of the centers and the bureau of medical and social examination of the regions were used. Processing of the primary material was performed using the universal statistical package "Excel". In 2018, medical and social expert commissions (MSEC) of Ukraine for the first time and re-certified and recognized persons with disabilities 7843 combatants. Of these, disability of group I (IA and IB) was established in 2.6 %, II – in 29.2 %, III – in 68.2 % of cases. All victims for MSEC were formed IRP. The dependence of the needs of combatants in medical and social rehabilitation measures on the severity of disability has been established. For persons with disabilities of groups II and III, priority is given to medical and professional rehabilitation, group I – social rehabilitation and technical means of rehabilitation with medical support. Of the medical rehabilitation services for persons with II and III groups of disability, sanatorium treatment is significant, and group I – rehabilitation therapy. Among vocational rehabilitation services, employment in production conditions is important – for persons with group III disabilities, in specially created conditions – for persons with group II disabilities, at home – for persons with group I disabilities. Vocational training was offered to a small number of people with disabilities of all groups. Among social rehabilitation services and technical means of rehabilitation, the services of social workers of territorial social service centers were significant for representatives of all disability groups, simpler means of transportation for persons of group III disability and more complex means for persons of group I. Determining the characteristics of the needs of servicemen with disabilities depending on its severity allows MSEC specialists to better form the IRP, develop targeted rehabilitation programs at the regional level, assess shortcomings in the organization of the rehabilitation process and build a rehabilitation system for combatants.

scholarly journals Anaesthesia Circuits, Humidity Output, and Mucociliary Structure and Function

1998 ◽  
Vol 26 (2) ◽  
pp. 178-183 ◽  
Author(s):  
R. D. Branson ◽  
R. S. Campbell ◽  
K. Davis ◽  
D. T. Porembka
Keyword(s):  
Minute Ventilation ◽  
Absolute Humidity ◽  
Tracheobronchial Tree ◽  
Open Circuit ◽  
Structure And Function ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
And Function ◽  
Circuit Technique

We compared the effects of humidity delivered by the circle system at low fresh gas flows (FGF) with a conventional two-limb and coaxial circuit on the structure and function of the tracheobronchial epithelium in dogs. Animals were anaesthetized and mechanically ventilated using an anaesthesia ventilator to maintain normocarbia. Group I (control) animals received a FGF equal to the required minute ventilation mimicking an open circuit technique. Group II and III animals had FGF set at 20% of the required minute ventilation. Group II used a two-limb circuit and Group III used a coaxial circuit. Relative humidity and temperature of inspired gases were measured at baseline and hourly afterwards. In the first experiment, biopsies of the tracheobronchial tree were obtained bronchoscopically at baseline and then hourly for six hours. Microscopic examination of these samples allowed calculation of mean ciliary length. In the second experiment, tracheal mucus flow velocity (TMFV) was measured at baseline and hourly afterward, using a cinebroncho-fibrescopic method. Delivered absolute humidity was greatest with low FGF and the coaxial circuit, followed by low FGF and a conventional circuit, and high FGF (15±1.4 vs 9±0.8 vs 5±0.4 mg H2O, P<0.01) after two hours. Mean cilia length (μ m) and TMFV (mm/min) fell during the first hour in all three groups. At hour two TMFV returned to baseline in Group III and was significantly greater than Groups I and II (0.8±0.4 vs 8.6±1.1 vs 15.4±2.1, P<0.001). Mean ciliary length demonstrated a similar pattern with reductions from baseline in all three groups for the first two hours. Groups II and III had an increase in cilia length beginning at hour three and were both significantly greater than Group I at hours 3 through 6 (1.3±0.5 vs 3.2±1.1 vs 4.2±0.8, P <0.001). Alterations in tracheobronchial structure and function result from exposure to dry gases and are amplified by the duration of exposure. Our findings suggest a minimum of 12 to 15 mg H2O/l is necessary to prevent these alterations. In this study, the combination of low FGF and a coaxial anaesthesia circuit reached this minimum threshold more quickly than a conventional two-limb circuit.

scholarly journals INFLUENCE OF PHYSICAL REHABILITATION ON QUALITY OF LIFE AFTER RENAL TRANSPLANTATION

2015 ◽  
Vol 69 (3-4) ◽  
pp. 65-70 ◽  
Author(s):  
T. Y. Zhirnova ◽  
E. E. Аchkasov ◽  
O. M. Tsirulnikova ◽  
E. M. Shilov ◽  
O. B. Dobrovolskiy
Keyword(s):  
Quality Of Life ◽  
Kidney Transplantation ◽  
Organ Transplant ◽  
Rehabilitation Program ◽  
Physical Rehabilitation ◽  
Group Iii ◽  
Results Of Treatment ◽  
Group I ◽  
Group Ii

Background: Aim of this study was to evaluate the role of physical rehabilitation to improve the quality of life (QOL) of people after kidney transplantation. Patients and methods: Analyzes the results of treatment of 57 recipients (mean age 35±9,65 years) donor kidney at different times of the postoperative period. Depending on the physical rehabilitation program allocated 3 groups of patients: group II — physical rehabilitation was carried out only in the first week after surgery to prevent early postoperative complications, in group I — during the year; in group III combined 30 relatively healthy people do not need an organ transplant and with a mean age 33,7±8,7 years, leading a normal life, not engaged in regular recreational physical culture. Quality of life was assessed using a questionnaire SF36 at 1, 3, 6 and a 12 months after surgery. Results: One year after surgery in both groups compared with preoperative indicators marked improvement according to all scales of the questionnaire. However, in group I indicators of quality of life were higher than in group II from 11,4 to 19,7%, and even some items questionnaire SF-36 is higher than in group III which is associated with the physical rehabilitation. Conclusion: It has been shown that exercises is an important component of treatment and rehabilitation after kidney transplantation and help improve both the psychological and the physical component of quality of life.

scholarly journals AB0797 THE ROLE OF ULTRASOUND CRITERIA IN ASSESSING PAIN SYNDROME IN THE KNEE JOINT IN PATIENTS WITH RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1423.1-1423
Author(s):  
N. Aleksandrova ◽  
A. Aleksandrov
Keyword(s):  
Rheumatoid Arthritis ◽  
Knee Joint ◽  
Synovial Membrane ◽  
Pain Syndrome ◽  
Synovial Proliferation ◽  
Group Iii ◽  
Joint Cavity ◽  
Group I ◽  
Number Of Patients ◽  
Group Ii

Background:Pain syndrome and pathological changes in the synovium detected by ultrasound can be early signs of various diseases of the joints [1].Objectives:the use of ultrasound criteria for changes in the synovial membrane of the joint cavity to assess the severity of pain in patients with rheumatoid arthritis (RA) and osteoarthritis (OA).Methods:The study included 36 patients with RA (32 women and 4 men aged 22 to 55 years old) and 38 patients with OA (30 women and 8 men aged 30 to 50 years old) with lesions of the knee joints. A visual analogue scale (VAS) was used to determine the severity of pain. The severity of pain in the knee when walking was at least 40 mm according to the VAS in all examined patients. Joint ultrasound examination was carried out according to the standard technique using a linear transducer with a frequency of 5–12 MHz on an Accuvix V10 ultrasound diagnostic system (Samsung Medison, South Korea). The evaluation of ultrasound changes in the upper inversion of a knee joint was carried out according to the following criteria: the severity of intra-articular effusion (1), synovial proliferation (2), local vascularization of the synovial membrane using power Doppler (3) (Table 1).Table 1.Parameters of ultrasound criteria for assessing changes in the synovial membrane of the joint cavityNormal indicators1 - width of the suprapatellar turn is 6 mm2 - thickness of the synovial membrane is 3 mm (from the anterior approach)3 - lack of vascularization lociMinimum changes1 - delamination of the suprapatellar curl leaves from 7 to 9 mm2 - thickness of the synovial membrane 3.1–4.5 mm3 - appearance of single loci of vascularization (1-2 in the Doppler field)Moderate changes1 - delamination of the leaves of the suprapatellar twist 10-14 mm2 - thickness of the synovial membrane is 4.6–6.4 mm3 - appearance of moderate (> 5) vascularization lociSevere changes1 - delamination of suprapatellar folds of more than 15 mm2 - thickness of the synovial membrane is more than 6.5 mm3 - multiple foci of vascularization (> 5, merging in places)Results:Correlations of various severity were found between pain indices according to VAS and the thickness of the synovial membrane of the knee joint (r = 0.33, p = 0.019) and the number of vascularization foci (rS = 0.29, p = 0.04) in RA patients, as well as between pain according to VAS and the severity of intra-articular effusion (r = 0.28, p <0.002) in patients with OA.The patients were divided into three groups according to the severity of pain in the knee joint: group I - 41-59 mm (12 patients with OA and 9 patients with RA), group II - 60-79 mm (16 patients with OA and 12 patients with RA), group III - 80–100 mm on the VAS scale (10 patients with OA and 15 patients with RA). Group I was dominated by OA patients with minimal changes in intra-articular effusion and local vascularization of the synovial membrane, with moderate synovial proliferation (28.6% of the total number of patients in the group). In group II patients with OA with moderate severity of intra-articular effusion and local vascularization (21.4%) and patients with RA with moderate changes in the thickness of the synovium and local vascularization (25%) were equally common. Group III was dominated by RA patients with severe synovial proliferation and moderate local vascularization (28%), as well as patients with OA with moderate intra-articular effusion (20%).Significant differences in the thickness of the synovium in patients with RA in the first and third groups were noted (H-test = 5.9, p = 0.025).Conclusion:The additional use of ultrasound criteria for changes observed in the synovial membrane of the joint cavity in patients with RA and OA can help predict pain in the knee joint. The manifestation of pain syndrome in patients with OA is most associated with the severity of synovitis in the joint, and in patients with RA - with the severity of synovial proliferation.References:[1]Sarmanova A et al. Arthritis Res Ther. 2017;19(1):281.Disclosure of Interests:None declared

Programmes for a NC Command Rehabilitation Equipment Designed for Knee and Hip Affections Recovery

2015 ◽  
Vol 809-810 ◽  
pp. 628-633
Author(s):  
Ioana Mădălina Petre ◽  
Andrea Deaconescu
Keyword(s):  
Knee Joint ◽  
Experimental Research ◽  
Hip Joint ◽  
Rehabilitation Program ◽  
Pneumatic Muscle ◽  
Rehabilitation Programs ◽  
Knee Rehabilitation ◽  
Transylvania University

The aim of the article is to present an experimental research on the behavior of a pneumatic muscle actuated rehabilitation device for hip/knee affections, developed in a laboratory from Transylvania University of Brașov. The equipment has been tested and studied its response to some rehabilitation programs implemented: one for hip joint recovery and other for knee joint recovery. For the research was used WINPISA software with the two programs created by the researchers using NC commands. The knee rehabilitation program consists of slider displacement corresponding to a rotating angle of the knee of 75 degrees with a short temporization and the hip joint rehabilitation program consists of slider displacement corresponding to a rotating angle of the hip of 40 degrees. The results of experiments present the displacement of the slider which effectuates the rehabilitation moves, the velocity and acceleration in a proposed time.

Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability: Table 1

2010 ◽  
Vol 69 (3) ◽  
pp. 585-587 ◽  
Author(s):  
Jessica Bijsterbosch ◽  
Willemien Visser ◽  
Herman M Kroon ◽  
Tanja Stamm ◽  
Ingrid Meulenbelt ◽  
...  
Keyword(s):  
Mixed Models ◽  
Functional Disability ◽  
Hand Osteoarthritis ◽  
Group Iii ◽  
Family Effects ◽  
Group I ◽  
Grading Scale ◽  
And Function ◽  
The Impact ◽  
Index Family

ObjectiveTo assess the impact of different subsets of symptomatic hand osteoarthritis (OA) on pain and disability.MethodsFrom 308 patients with hand OA a group with carpometacarpal joint (CMCJ) symptoms only (group I, n=20) was identified as well as groups with symptoms at the interphalangeal joints (IPJs) only (group II, n=138), and symptoms at both sites (group III, n=150). Hand pain and function, assessed with the AUSCAN, were compared between groups using linear mixed models. Radiological OA was assessed using the Kellgren–Lawrence grading scale.ResultsMean (SD) AUSCAN scores for groups I, II and III were 23.1 (11.7), 18.3 (11.9) and 26.4 (12.5), respectively. After adjustment for age, gender, body mass index, family effects and number of symptomatic hand joints, significant differences in AUSCAN scores of 7.4 (95% CI 1.8 to 13.0) between groups I and II, and 5.7 (95% CI 2.7 to 8.6) between groups II and III were found. AUSCAN scores were 5.8 (95% CI 3.1 to 8.6) higher for patients with versus patients without CMCJ symptoms. Kellgren–Lawrence scores did not differ between groups.ConclusionIn symptomatic hand OA, CMCJ OA contributes more to pain and disability than IPJ OA. Hence, treatment of CMCJ OA should be emphasised, even if it coincides with IPJ OA.

Establishment of Bacteroides succinogenes and measurement of the main digestive parameters in the rumen of gnotoxenic lambs

1988 ◽  
Vol 34 (8) ◽  
pp. 938-946 ◽  
Author(s):  
G. Fonty ◽  
P. Gouet ◽  
Harinirina Ratefiarivelo ◽  
J. P. Jouany
Keyword(s):  
Fatty Acid ◽  
Volatile Fatty Acid ◽  
Group Iv ◽  
Cellulolytic Bacteria ◽  
Bacterial Strains ◽  
Group Iii ◽  
Volatile Fatty Acid Concentration ◽  
Group I ◽  
Group Ii ◽  
And Function

We attempted to determine the degree of diversification of the microflora that allow the establishment of Bacteroides succinogenes S85 in the rumen of gnotoxenic lambs. Four lambs (group I) received an inoculum orally, composed of 182 noncellulolytic bacterial strains (inoculum 1) previously isolated from the rumen of conventional young lambs. Two lambs (group II) were inoculated with 32 strains (inoculum 2) selected among the 182 strains of inoculum 1. Two lambs (group III) received an inoculum (inoculum 3) composed of 106 noncellulolytic bacterial strains previously isolated from the rumen of meroxenic lambs. Two lambs (group IV) were inoculated with 16 strains (inoculum 4) chosen among the 106 strains of inoculum 3. All lambs were inoculated from birth except two lambs of group I, which were inoculated from 1 month of age. Each lamb then received orally a pure culture of B. succinogenes. This strain became established more easily in the rumen of lambs that had received complex inocula (group I). Its population reached a level close to that generally observed in conventional lambs (107–108 bacteria mL−1). In contrast, B. succinogenes became established in only one lamb of group II, but bacterial numbers varied considerably. In group III, repeated inoculations were necessary to obtain its definitive establishment (107–108 bacteria mL−1 after weaning). In spite of several inoculations, this cellulolytic species failed to establish in the rumen of lambs of group IV, which had received the less complex inoculum. The volatile fatty acid levels were very different from one lamb group to another. The more complex the inoculum administered to the animals, the higher the concentration. In those that received inoculum 1, the volatile fatty acid concentration was similar to that measured in conventional lambs fed the same diet (approximately 80 mmol L−1 after feeding). In lambs inoculated with only 16 strains there were almost no fermentations (30 mmol L−1 of volatile fatty acid). These results demonstrate that the establishment of cellulolytic bacteria, functions of the rumen, and the stability of the ecosystem depend on the complexity and diversity of the microflora. In the light of present knowledge, it is not possible to determine accurately the operative composition of the minimum flora enabling rumen development and function.

scholarly journals Effects of Four-Week Rehabilitation Program on Hemostasis Disorders in Patients with Spinal Cord Injury

2020 ◽  
Vol 9 (6) ◽  
pp. 1836
Author(s):  
Magdalena Mackiewicz-Milewska ◽  
Małgorzata Cisowska-Adamiak ◽  
Danuta Rość ◽  
Iwona Głowacka-Mrotek ◽  
Iwona Świątkiewicz
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Tissue Factor ◽  
Rehabilitation Program ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Cord Injury ◽  
Before And After ◽  
D Dimer

Background: Patients with spinal cord injury (SCI) exhibit hemostasis disorders. This study aims at assessing the effects of a 4-week rehabilitation program on hemostasis disorders in patients with SCI. Methods: Seventy-eight in-patients undergoing a 4-week rehabilitation were divided into three groups based on time elapsed since SCI: I (3 weeks–3 months), II (3–6 months), and III (>6 months). Tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombin–antithrombin complex (TAT) and D-dimer levels, antithrombin activity (AT), and platelet count (PLT) were measured on admission and after rehabilitation. Results: Rehabilitation resulted in an increase in TF in group III (p < 0.050), and decrease in TFPI (p < 0.022) and PLT (p < 0.042) in group II as well as AT in group I (p < 0.009). Compared to control group without SCI, TF, TFPI, and TAT were significantly higher in all SCI groups both before and after rehabilitation. All SCI groups had elevated D-dimer, which decreased after rehabilitation in the whole study group (p < 0.001) and group I (p < 0.001). Conclusion: No decrease in activation of TF-dependent coagulation was observed after a 4-week rehabilitation regardless of time elapsed since SCI. However, D-dimer levels decreased significantly, which may indicate reduction of high fibrinolytic potential, especially when rehabilitation was done <3 months after SCI.

Right ventricular hypertrophy long after reversal of severe pressure overload in cats

1988 ◽  
Vol 254 (6) ◽  
pp. H1099-H1104
Author(s):  
T. Wisenbaugh ◽  
W. N. O'Connor
Keyword(s):  
Right Ventricular ◽  
Systolic Pressure ◽  
Pressure Overload ◽  
Left Ventricular ◽  
Surgical Removal ◽  
Stroke Work ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
And Function

To test the hypothesis that alterations in ventricular size and function may persist long after reversal of a severe pressure overload, right ventricular (RV) hypertrophy was produced in cats by abrupt, severe constriction of the pulmonary artery (PA) for 8 wk, after which pressure overload was completely reversed by surgical removal of the PA band (group III). Despite debanding and recovery from pressure overload (RV peak systolic pressure = 22 +/- 4 vs. 66 +/- 20 mmHg before debanding and 25 +/- 4 mmHg in controls), parameters of hypertrophy 8–10 mo later remained substantially increased: e.g., RV/LV (left ventricular) mass ratio was 0.36 +/- 0.06 in group III vs. 0.24 +/- 0.03 in controls (group I) and 0.43 +/- 0.07 in a separate cohort (group II) studied after 8 wk of banding. Maximum RV stroke work during volume loading was computed from RV micromanometry and PA electromagnetic flow: 20 +/- 8 g-cm/g for group III vs. 51 +/- 14 for group I, P less than 0.05, and 21 +/- 7 for group II. Thus severe pressure overload of the RV may produce changes in size and function that are not fully reversed by complete removal of the overload.

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