scholarly journals Nebivolol Ameliorates Nitric Oxide–Deficient Hypertension

2002 ◽  
Vol 2 ◽  
pp. 1676-1684 ◽  
Author(s):  
L.A. Fortepiani ◽  
M.C. Ortiz ◽  
N.M. Atucha ◽  
Joaquin Garcia-Estan
Keyword(s):  
Nitric Oxide ◽  
Arterial Hypertension ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
No Synthase ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibitor ◽  
Angiotensin System ◽  
Calcium Dependent ◽  
Adrenoceptor Antagonist

Nebivolol is a new selective beta 1-adrenoceptor antagonist with nitric oxide (NO)–releasing properties. In the present study we have analyzed whether nebivolol affects the development of the arterial hypertension that follows the chronic inhibition of nitric oxide synthesis. Nebivolol (1 mg/kg/day, 14 days) was given concurrently with the NO synthesis inhibitor Nw-nitro-L-arginine methyl ester (L-NAME, 0.1, 1, and 10 mg/kg/day, 14 days) to several groups of rats. Blood pressure, renal function, plasma renin activity (PRA), and NO activity and metabolites were measured at the end of the treatment period. L-NAME treatment alone increased mean arterial pressure dose dependently (103.5 ± 2.4, 110.9 ± 2.0, and 125.8 ± 2.2 mmHg, respectively). Nebivolol completely prevented the development of arterial hypertension in the groups treated with L-NAME at the doses of 0.1 and 1 mg/kg/day and reduced the increase achieved with the L-NAME dose of 10 mg/kg/day (110.3 ± 2.7). There were no differences in glomerular filtration rate or natriuresis between nebivolol-treated and -untreated rats. Plasma nitrates+nitrites and calcium-dependent NO synthase activity in the kidney also decreased dose dependently with L-NAME treatment and nebivolol did not significantly modify it. However, PRA was lower in all groups treated with nebivolol and L-NAME as compared to the rats receiving only L-NAME. These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system.

The activity of renin-angiotensin system in patients with arterial hypertension in population of the Gornaia Shoria

2016 ◽  
Vol 22 (3) ◽  
pp. 129-133
Author(s):  
Tatiana A. Mulerova ◽  
E. G Uchasova ◽  
A. N Chigisova ◽  
M. Yu Ogarkov
Keyword(s):  
Left Ventricle ◽  
Arterial Hypertension ◽  
Ethnic Group ◽  
Indigenous Population ◽  
Clinical Medicine ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Indigenous Ethnic Group

The study was carried out to investigate characteristics of pathophysiological variants of arterial hypertension depending on activity of plasma renin in indigenous (Shors) and non-indigenous population of the Gornaia Shoria.The clinical epidemiological study was carried out concerning indigenous population of hard-to-reach regions of the Gornaia Shoria. The continuous sampling technique was applied on the basis of nominal lists to select 837 residents of the mentioned villages (513 personf of indigenous population (Shors) and 324 of non-indigenous population). The particular sampling consisted of adult population, including individuals of 18 years and older. The activity of plasma renin was evaluated using test-systems of BRG (Germany). All examined patients were separated in two groups. The first group included patients with arterial hypertension with concentration of plasma renin > 47,85 picograms per ml (development of disease is related to excessive release of renin and activation of renin-angiotensin system). The second group included patients wit arterial hypertension with content of plasma renin < 47,85 picograms per ml (arterial hypertension is related to suppression of release of renin and retention of sodium in organism). The renin - dependent arterial hypertension more was often found among representatives of non-indigenous nationality (89,8 % against 65,5%) and the volume-dependent arterial hypertension - among representatives of indigenous nationality (34,4 % against 10,1%). In the indigenous ethnic group of Shors the renin - dependent arterial hypertension was associated with younger age and expressed structural functional alterations of heart in the form of increased index of myocardium mass of left ventricle. The volume-dependent arterial hypertension was associated with average age and increased indicator of thick- Clinical medicine ness of complex of intima-media. In non-indigenous ethnic group the renin - dependent arterial hypertension was associated with increased level of index of waist/thigh. The volume-dependent arterial hypertension was associated with expressed structural functional alterations of heart in the form of increased index of myocardium mass of left ventricle.

In vivo inhibition of nitric oxide synthesis does not depend on renin-angiotensin system activation

1996 ◽  
Vol 317 (2-3) ◽  
pp. 285-291 ◽  
Author(s):  
Aldete Zappellini ◽  
Simone A. Teixeira ◽  
Marcelo N Muscará ◽  
Roberto Zatz ◽  
Edson Antunes ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renin Angiotensin System ◽  
Nitric Oxide Synthesis ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
System Activation

Effects of renovascular hypertension on rat adrenal zona glomerulosa

1978 ◽  
Vol 36 (2) ◽  
pp. 582-583
Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer
Keyword(s):  
Renovascular Hypertension ◽  
Left Kidney ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Zona Glomerulosa ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Left Renal Artery ◽  
Angiotensin System ◽  
And Control

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.

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