SYNTHETIC SIALIC ACID ANALOGUES BINDING TO SIGLECS WITH HIGH AFFINITY AND SELECTIVITY

2002 ◽  
Author(s):  
Soerge Kelm ◽  
Nadine Bock ◽  
Karen Strenge ◽  
Reinhard Brossmer
Keyword(s):  
Sialic Acid ◽  
High Affinity ◽  
Sialic Acid Analogues

scholarly journals Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment

2017 ◽  
Vol 8 (9) ◽  
pp. 6165-6170 ◽  
Author(s):  
A. Matsumoto ◽  
A. J. Stephenson-Brown ◽  
T. Khan ◽  
T. Miyazawa ◽  
H. Cabral ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Boronic Acids ◽  
Sialic Acids ◽  
Strong Interactions ◽  
Acidic Ph ◽  
Acidic Environment ◽  
Selective Binding ◽  
High Affinity ◽  
Ph Conditions ◽  
Hypoxic Tumor

A group of heterocyclic boronic acids demonstrating unusually high affinity and selectivity for sialic acids are described, with strong interactions under the weakly acidic pH conditions associated with a hypoxic tumoral microenvironment.

Syntheses of sialic acid analogues with acylamino groups at C-4 (N-acyl regioisomers of sialic acids)

1997 ◽  
Vol 298 (3) ◽  
pp. 181-189 ◽  
Author(s):  
Xue-Long Sun ◽  
Toshitsugu Kai ◽  
Hiroaki Takayanagi ◽  
Kimio Furuhata
Keyword(s):  
Sialic Acid ◽  
Sialic Acids ◽  
Sialic Acid Analogues

Synthetic studies of new CMP–sialic acid analogues applying a novel buffer-mediated rearrangement

2007 ◽  
Vol 48 (49) ◽  
pp. 8757-8760 ◽  
Author(s):  
Satomi Niwayama ◽  
Venkata Subbarao Kandula ◽  
Hezhen Wang ◽  
Xiao Chen
Keyword(s):  
Sialic Acid ◽  
Sialic Acid Analogues ◽  
Synthetic Studies

Synthesis of Sialic Acid Analogues with the Oxime Group at C-4 Or C-5 of KDN1

1997 ◽  
Vol 16 (4-5) ◽  
pp. 521-532 ◽  
Author(s):  
Toshitsugu Kai ◽  
Xue-Long Sun ◽  
Hiroaki Takayanagi ◽  
Kimio Furuhata
Keyword(s):  
Sialic Acid ◽  
Oxime Group ◽  
Sialic Acid Analogues
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