CHEMICAL SYNTHESIS AND BIOSYNTHETIC PATHWAYS OF NUCLEOTIDE-ACTIVATED HEPTOSES

2002 ◽  
Author(s):  
Bernd Kneidinger ◽  
Alla Zamyatina ◽  
Miguel Valvano ◽  
Paul Messner ◽  
Paul Kosma
Keyword(s):  
Chemical Synthesis ◽  
Biosynthetic Pathways

scholarly journals Constructing de Novo Biosynthetic Pathways for Chemical Synthesis inside Living Cells

Biochemistry ◽  
2011 ◽  
Vol 50 (24) ◽  
pp. 5404-5418 ◽  
Author(s):  
Amy M. Weeks ◽  
Michelle C. Y. Chang
Keyword(s):  
Chemical Synthesis ◽  
De Novo ◽  
Living Cells ◽  
Biosynthetic Pathways

Synthesis of Secosterols as an Arena for C–H Functionalization and C–C Manipulation Tactics

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1127-1133 ◽  
Author(s):  
Philipp Heretsch ◽  
Robert Heinze
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Current Literature ◽  
Ring Expansion ◽  
Biosynthetic Pathways ◽  
Radical Ring ◽  
Synthetic Intermediates ◽  
Synthetic Work ◽  
Shed Light

The chemical synthesis of secosterols is an arena for the application of C–H functionalization methods as well as C–C manipulations. Studies on the innate reactivity of synthetic intermediates to undergo C–C scissions and rearrangements can shed light on biosynthetic pathways, or, provide proof for biosynthetic proposals. Examples of the authors work (synthesis of the 14,15-secosterol strophasterol A), as well as examples from current literature (Tian’s synthetic work on 13,14:14,15-disecosterols glaucogenins C and D, and Baran’s synthesis of 9,10-secosterol cortistatin A) are discussed.1 Introduction2 The Synthesis of Strophasterol A Employing the Concept of Innate Reactivity3 Synthetic Work in the Glaucogenin Family of Natural Products4 The Synthesis of Cortistatin A Using a Radical Ring Expansion5 Conclusion

scholarly journals Unified Total Synthesis of the Brevianamide Alkaloids Enabled by Chemical Investigations into their Biosynthesis.

2021 ◽  
Author(s):  
Robert C. Godfrey ◽  
Helen E. Jones ◽  
Nicholas J. Green ◽  
Andrew L. Lawrence
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Total Synthesis ◽  
Scientific Community ◽  
Biological Activities ◽  
Focus Of Attention ◽  
Complex Structures ◽  
Biosynthetic Pathways ◽  
Synthetic Strategy ◽  
Synthetic Studies

The bicyclo[2.2.2]diazaoctane alkaloids are a vast group of natural products which have been the focus of attention from the scientific community for several decades. This interest stems from their broad range of biological activities, their diverse biosynthetic origins, and their topologically complex structures, which combined make them enticing targets for chemical synthesis. In this article, full details of our synthetic studies into the chemical feasibility of a proposed network of biosynthetic pathways towards the brevianamide family of bicyclo[2.2.2]diazaoctane alkaloids are disclosed. Insights into issues of reactivity and selectivity in the biosynthesis of these structures have aided the development of a unified biomimetic synthetic strategy, which has resulted in the total synthesis of all known bicyclo[2.2.2]diazaoctane brevianamides and the anticipation of an as-yet-undiscovered congener.

scholarly journals A Fully Biocatalytic Approach to Angiopterlactone B Based on a Chemoinspired Artificial in Vitro Metabolism

2021 ◽  
Author(s):  
Alexander Kiefer ◽  
Yu-Chang Liu ◽  
Rebecca Gummerer ◽  
Christina Jäger ◽  
Jan Deska
Keyword(s):  
Chemical Synthesis ◽  
Total Synthesis ◽  
In Vitro Metabolism ◽  
Biosynthetic Pathways ◽  
Target Structure

<p>Nature's way to construct highly complex molecular entities with virtue as part of biosynthetic pathways is unmatched by any chemical synthesis. Yet, relying on a cascade of native enzymatic transformations to achieve a certain target structure, biosynthesis is also significantly limited in its scope. In this work, non-natural biocatalytic modules are successfully implemented into an artificial metabolism, combining the benefits of traditional retrosynthesis with the elegance and efficacy of biosynthetic networks. In a highly streamlined process, a fully enzymatic total synthesis of the tricyclic angiopterlactone B is achieved.<b></b></p>

scholarly journals A Fully Biocatalytic Approach to Angiopterlactone B Based on a Chemoinspired Artificial in Vitro Metabolism

2021 ◽  
Author(s):  
Alexander Kiefer ◽  
Yu-Chang Liu ◽  
Rebecca Gummerer ◽  
Christina Jäger ◽  
Jan Deska
Keyword(s):  
Chemical Synthesis ◽  
Total Synthesis ◽  
In Vitro Metabolism ◽  
Biosynthetic Pathways ◽  
Target Structure

<p>Nature's way to construct highly complex molecular entities with virtue as part of biosynthetic pathways is unmatched by any chemical synthesis. Yet, relying on a cascade of native enzymatic transformations to achieve a certain target structure, biosynthesis is also significantly limited in its scope. In this work, non-natural biocatalytic modules are successfully implemented into an artificial metabolism, combining the benefits of traditional retrosynthesis with the elegance and efficacy of biosynthetic networks. In a highly streamlined process, a fully enzymatic total synthesis of the tricyclic angiopterlactone B is achieved.<b></b></p>

Chemical synthesis of proteinoids: Part 1

1964 ◽  
Author(s):  
Sidney W. Fox ◽  
Kaoru Harada ◽  
Gottfried Krampitz ◽  
Tadao Hayakawa ◽  
Charles Ray Windsor
Keyword(s):  
Chemical Synthesis

Discovery of fatty acid synthase inhibitors and their biosynthetic pathways by a novel target-directed genome mining strategy

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
J Li ◽  
X Tang ◽  
JJ Zhang ◽  
EC O'Neill ◽  
SM Mantovani ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Genome Mining ◽  
Biosynthetic Pathways ◽  
Novel Target
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