scholarly journals Distribution of Receptor Activity Modifying Protein (RAMP) mRNAS in the Rat Central Nervous System

2001 ◽  
Vol 1 ◽  
pp. 45-45
Author(s):  
K. R. Oliver ◽  
A. M. Kinsey ◽  
N. Keyvan-Fouladi ◽  
R. Heavens ◽  
A. Wainwright
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Activity

Modulation of Nicotinic Receptor Activity in the Central Nervous System

2001 ◽  
Vol 15 ◽  
pp. S19-S25 ◽  
Author(s):  
E. X. Albuquerque ◽  
M. D. Santos ◽  
M. Alkondon ◽  
E. F. R. Pereira ◽  
A. Maelicke
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nicotinic Receptor ◽  
Receptor Activity ◽  
The Central Nervous System

scholarly journals Molecular Imaging Provides Novel Insights on Estrogen Receptor Activity in Mouse Brain

2008 ◽  
Vol 7 (6) ◽  
pp. 7290.2008.00027 ◽  
Author(s):  
Alessia Stell ◽  
Silvia Belcredito ◽  
Paolo Ciana ◽  
Adriana Maggi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Transcriptional Activity ◽  
Receptor Activity ◽  
Male And Female ◽  
Estrogen Receptor Activity ◽  
The Central Nervous System ◽  
Set Up

Estrogen receptors have long been known to be expressed in several brain areas in addition to those directly involved in the control of reproductive functions. Investigations in humans and in animal models suggest a strong influence of estrogens on limbic and motor functions, yet the complexity and heterogeneity of neural tissue have limited our approaches to the full understanding of estrogen activity in the central nervous system. The aim of this study was to examine the transcriptional activity of estrogen receptors in the brain of male and female mice. Exploiting the ERE-Luc reporter mouse, we set up a novel, bioluminescence-based technique to study brain estrogen receptor transcriptional activity. Here we show, for the first time, that estrogen receptors are similarly active in male and female brains and that the estrous cycle affects estrogen receptor activity in regions of the central nervous system not known to be associated with reproductive functions. Because of its reproducibility and sensitivity, this novel bioluminescence application stands as a candidate as an innovative methodology for the study and development of drugs targeting brain estrogen receptors.

scholarly journals Pro-survival signalling from the NMDA receptor

2006 ◽  
Vol 34 (5) ◽  
pp. 936-938 ◽  
Author(s):  
G.E. Hardingham
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptor ◽  
Glutamate Receptors ◽  
Receptor Activity ◽  
Ionotropic Glutamate Receptors ◽  
Acute Trauma ◽  
Mammalian Central Nervous System ◽  
Clinical Benefits ◽  
Opposing Effects

Ca2+ influx through the NMDA (N-methyl-D-aspartate) subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. While it mediates excitotoxic death triggered by stroke and other acute trauma, there is growing evidence that physiological levels of NMDA receptor activity promote survival. Understanding the mechanisms that underlie these opposing effects may lead to strategies to selectively block pro-death signalling, which could have considerable clinical benefits.

Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat

2001 ◽  
Vol 14 (4) ◽  
pp. 618-628 ◽  
Author(s):  
K. R. Oliver ◽  
S. A. Kane ◽  
C. A. Salvatore ◽  
J. J. Mallee ◽  
A. M. Kinsey ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Activity ◽  
Receptor Activity Modifying Proteins

Molecular studies of CGRP and the CGRP family of peptides in the central nervous system

Cephalalgia ◽  
2018 ◽  
Vol 39 (3) ◽  
pp. 403-419 ◽  
Author(s):  
Erica R Hendrikse ◽  
Rebekah L Bower ◽  
Debbie L Hay ◽  
Christopher S Walker
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcitonin Gene Related Peptide ◽  
Receptor Activity ◽  
Peptide Sequence ◽  
Calcitonin Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
The Central Nervous System ◽  
Receptor Biology

Background Calcitonin gene-related peptide is an important target for migraine and other painful neurovascular conditions. Understanding the normal biological functions of calcitonin gene-related peptide is critical to understand the mechanisms of calcitonin gene-related peptide-blocking therapies as well as engineering improvements to these medications. Calcitonin gene-related peptide is closely related to other peptides in the calcitonin gene-related peptide family of peptides, including amylin. Relatedness in peptide sequence and in receptor biology makes it difficult to tease apart the contributions that each peptide and receptor makes to physiological processes and to disorders. Summary The focus of this review is the expression of calcitonin gene-related peptide, related peptides and their receptors in the central nervous system. Calcitonin gene-related peptide is expressed throughout the nervous system, whereas amylin and adrenomedullin have only limited expression at discrete sites in the brain. The components of two receptors that respond to calcitonin gene-related peptide, the calcitonin gene-related peptide receptor (calcitonin receptor-like receptor with receptor activity-modifying protein 1) and the AMY1 receptor (calcitonin receptor with receptor activity-modifying protein 1), are expressed throughout the nervous system. Understanding expression of the peptides and their receptors lays the foundation for more deeply understanding their physiology, pathophysiology and therapeutic use.

Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

2019 ◽  
Vol 42 ◽  
Author(s):  
Kevin B. Clark
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gut Bacteria ◽  
Infection Cycle ◽  
Fair Weather ◽  
Host Health ◽  
Microbe Interactions ◽  
Animal Hosts ◽  
Host Infection ◽  
Neuropsychiatric Conditions

Abstract Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

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