scholarly journals One-Pot Synthesis ofβ-Acetamido Ketones Using Boric Acid at Room Temperature

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Zahed Karimi-Jaberi ◽  
Korosh Mohammadi
Keyword(s):  
Boric Acid ◽  
Room Temperature ◽  
Simple Procedure ◽  
Condensation Reaction ◽  
Solid Acid Catalyst ◽  
Reaction Times ◽  
Acid Catalyst ◽  
One Pot ◽  
Green Catalyst ◽  
One Pot Condensation

β-acetamido ketones were synthesized in excellent yields through one-pot condensation reaction of aldehydes, acetophenones, acetyl chloride, and acetonitrile in the presence of boric acid as a solid heterogeneous catalyst at room temperature. It is the first successful report of boric acid that has been used as solid acid catalyst for the preparation ofβ-acetamido ketones. The remarkable advantages offered by this method are green catalyst, mild reaction conditions, simple procedure, short reaction times, and good-to-excellent yields of products.

Adipic Acid as a Biodegradable Solid Acid Catalyst for One-Pot, Three Component Synthesis of 1-Amidoalkyl-2-naphthols

2019 ◽  
Vol 7 (1) ◽  
pp. 34-43
Author(s):  
Hassan Darbandi ◽  
Hamzeh Kiyani
Keyword(s):  
Adipic Acid ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Solid Acid Catalyst ◽  
Reaction Times ◽  
Acid Catalyst ◽  
Ultrasonic Waves ◽  
One Pot ◽  
Solvent Free Conditions ◽  
High Yields

Background: 1-Amidoalkyl-2-naphthols are an attractive group of organic compounds that can be converted to oxazine heterocycles and aminoalkyl naphthols. The derivatives of 1- amidoalkyl-2-naphthols have significant biological activities and act as drug candidates. Methods: 1-Amidoalkyl-2-naphthols were synthesized via the three-component condensation reaction of 2-naphthol, acetamide/benzamide and various aldehydes in the presence of 10 mol% of adipic acid as an organocatalyst under solvent-free conditions at 120°C. Results: A simple, efficient, and operative method for the synthesis of 1-amidoalkyl-2-naphtholes in the presence of adipic acid as the biodegradable catalyst is introduced. Easy operation, acceptable reaction times, eco-friendly, availability of starting materials, simple separation of products, and high yields of products are the significant results of this method. Conclusion: In this study, 1-amidoalkyl-2-naphthols were synthesized using commercially available reactants in excellent yields and relatively shorter times. In this process, microwave or ultrasonic waves were not used to provide energy for the reaction.

scholarly journals Citric acid as a green and naturally biodegradable catalyst promoted convenient synthesis of polysubstituted dihydro-2-oxypyrrole derivatives via four-condensation reaction of dialkylacetylenedicarboxylate, formaldehyde and amines

2019 ◽  
Vol 9 (4) ◽  
pp. 4096-4100
Keyword(s):  
Citric Acid ◽  
Low Cost ◽  
Condensation Reaction ◽  
Solid Acid Catalyst ◽  
Reaction Times ◽  
Acid Catalyst ◽  
One Pot ◽  
Convenient Synthesis ◽  
High Yields ◽  
Work Up

Citric acid is found to be a green and naturally biodegradable catalyst for one-pot, four-condensation of dialkylacetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) to afford the corresponding polysubstituted dihydro-2-oxypyrrole derivatives under ambient temperature. The remarkable features of this one-pot procedure are green and low-cost catalyst, high yields, short reaction times, simplicity of operation and work-up procedures, the availability and easy to handle of this solid acid catalyst, avoidance of hazardous or toxic catalyst and mild reaction conditions.

Efficient Synthesis of 2,3-Dihydro-1H-Perimidine Derivatives Using HBOB as a Novel Solid Acid Catalyst

2012 ◽  
Vol 65 (1) ◽  
pp. 86 ◽  
Author(s):  
Sunanda B. Phadtare ◽  
R. Vijayraghavan ◽  
Ganapati S. Shankarling ◽  
Douglas R. MacFarlane
Keyword(s):  
Boric Acid ◽  
Efficient Method ◽  
Solid Acid ◽  
Simple Procedure ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Thermal Processes ◽  
Efficient Synthesis ◽  
Acid Catalyzed ◽  
Time Required

An efficient method for the synthesis of substituted 2,3-dihydro-1H-perimidine derivatives is described using bis(oxalato)boric acid (HBOB) as catalyst. The methodology provides an easily handled and recyclable catalyst for this type of reaction as an alternative platform to the conventional acid-catalyzed thermal processes. The time required to complete the reaction using HBOB was found to be shorter than conventional methods. Recycling of the catalyst has been efficiently achieved using a simple procedure.

Envirocat EPZ-10: An Efficient Catalyst for the Synthesis of 1,2,4- Triazolidine-3-thiones

2020 ◽  
Vol 17 (4) ◽  
pp. 321-326
Author(s):  
Pradeep M. Mhaldar ◽  
Dattaprasad M. Pore
Keyword(s):  
Present Method ◽  
Room Temperature ◽  
Solid Acid ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Environmentally Benign ◽  
Temperature Synthesis ◽  
Efficient Catalyst ◽  
Green Catalyst ◽  
Catalyst Reusability

A simple and environmentally benign room temperature synthesis of 1,2,4-triazolidine-3- thiones is described using Envirocat EPZ-10R as a solid acid catalyst in the aqueous medium. The use of Envirocat EPZ-10R as a green catalyst, reusability of the catalyst, water as a universal solvent and good yields of the product are the attractive features of the present method.

SO3H-functionalized mesoporous silica materials as solid acid catalyst for facile and solvent-free synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-trione derivatives

2015 ◽  
Vol 39 (12) ◽  
pp. 9665-9671 ◽  
Author(s):  
Ali Alinasab Amiri ◽  
Shahrzad Javanshir ◽  
Zahra Dolatkhah ◽  
Mohammad G. Dekamin
Keyword(s):  
Mesoporous Silica ◽  
Solid Acid ◽  
Condensation Reaction ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
One Pot ◽  
Functionalized Mesoporous Silica ◽  
Silica Materials ◽  
Mesoporous Silica Materials ◽  
Solvent Free Synthesis

SO3H-functionalized mesoporous silica materials were used to synthesize 2H-indazolo[2,1-b]phthalazine-1,6,11-trione derivatives in a one-pot three-component condensation reaction.

scholarly journals One-pot Three-component Synthesis of β-amino Carbonyl Compounds Using Nanocrystalline Solid Acid Catalyst

2013 ◽  
Vol 1 ◽  
pp. 194308921350716 ◽  
Author(s):  
Abbas Teimouri ◽  
Leila Ghorbanian
Keyword(s):  
Carbonyl Compounds ◽  
Organic Molecules ◽  
Solid Acid ◽  
Solid Acid Catalyst ◽  
Reaction Times ◽  
Acid Catalyst ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
One Pot ◽  
The Mannich Reaction

This study presents a simple highly versatile and efficient synthesis of various β-amino carbonyl compounds in the Mannich reaction of acetophenone with aromatic aldehydes and aromatic amines in the presence of nanosulfated zirconia, nanostructured ZnO, nano-γ-alumina, and nano-ZSM-5 zeolites as the catalyst in ethanol at moderate temperature. The optical properties of the nanostructured organic molecules were studied. The advantages of methods are short reaction times, milder conditions, easy workup, and purification of products by nonchromatographic methods. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency.

scholarly journals LEUCINE : AN EFFICIENT AND GREEN AMINO ACID CATALYST FOR CONVERSION OF ALDEHYDES AND KETONES INTO GEM-DIHYDROPEROXIDES WITH H2O2

2016 ◽  
Vol 11 (2) ◽  
pp. 3452-3458 ◽  
Author(s):  
Davood Azarifar ◽  
Ommolbanin Badalkhani ◽  
Kaveh Khosravi ◽  
Younes Abbasi
Keyword(s):  
Amino Acid ◽  
Present Method ◽  
Room Temperature ◽  
Reaction Times ◽  
Acid Catalyst ◽  
Aqueous Hydrogen Peroxide ◽  
Reaction Conditions ◽  
Green Catalyst ◽  
Aldehydes And Ketones ◽  
High Yields

Leucine amino acid, has been explored as an effective catalyst for conversion of ketones and aldehydes into corresponding gem-dihydroperoxides using 30% aqueous hydrogen peroxide in acetonitrile at room temperature. The reactions proceed smoothly within short periods of time to provide the respective gem-dihydroperoxides in excellent yields. Mild reaction conditions, low reaction times, high yields, low environmental impact, use of non-expensive, recyclable and green catalyst are the main merits of the present method.

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