scholarly journals The c.1460C>T Polymorphism ofMAO-AIs Associated with the Risk of Depression in Postmenopausal Women

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
R. Słopień ◽  
A. Słopień ◽  
A. Różycka ◽  
A. Warenik-Szymankiewicz ◽  
M. Lianeri ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Tryptophan Hydroxylase ◽  
Rating Scale ◽  
Monoamine Oxidase A ◽  
Control Group ◽  
Serotoninergic System ◽  
Mao A ◽  
17Β Estradiol ◽  
Polymerase Chain ◽  
Hamilton Rating Scale

Objective. The aim of the study was an evaluation of possible relationships between polymorphisms of serotoninergic system genes and the risk of depression in postmenopausal women.Methods. We studied 332 women admitted to our department because of climacteric symptoms. The study group included 113 women with a diagnosis of depressive disorder according to the Hamilton rating scale for depression; the controls consisted of 219 women without depression. Serum 17β-estradiol concentrations were evaluated using radioimmunoassay, while polymorphisms in serotoninergic system genes: serotonin receptors 2A (HTR2A), 1B (HTR1B), and 2C (HTR2C); tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), and monoamine oxidase A (MAO-A) were evaluated using polymerase chain reaction-restriction.Results. We found that the 1460T allele ofMAO-Ac.1460C>T (SNP 1137070) appeared with a significantly higher frequency in depressed female patients than in the control group (P=0.011) and the combined c.1460CT + TT genotypes were associated with a higher risk of depression (P=0.0198). Patients with the 1460TT genotype had a significantly higher 17β-estradiol concentration than patients with the 1460CT genotype (P=0.0065) and 1460CC genotype (P=0.0018).Conclusions. We concluded that depression in postmenopausal women is closely related to the genetic contribution ofMAO-A.

P2536Protective effects of ultra-low-dose menopausal hormonal therapy on endothelium function in postmenopausal women

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S N Tolstov ◽  
I A Salov ◽  
A P Rebrov
Keyword(s):  
Endothelial Function ◽  
Postmenopausal Women ◽  
Functional State ◽  
Low Dose ◽  
Vascular Wall ◽  
Control Group ◽  
Protective Effects ◽  
Group A ◽  
17Β Estradiol ◽  
Von Willebrand

Abstract Introduction This is the first pilot study to assess the functional state of the vascular wall in postmenopausal women on the background of ultra low-dose menopausal hormone therapy (MHT). Purpose To evaluate the protective effects on endothelial function of ultra-low-dose MHT 0.5 mg of 17β-estradiol (E2) and 0.25 mg of drospirenone (DRSP) in postmenopausal women. Methods The study included 115 previously examined postmenopausal women. Group 1 (n=25) included patients who started receiving MGT with DRSP during the menopausal transition; in the 2nd group (n=31), women who started receiving MGT with DRSP in the early postmenopausal period. Women of the 1st and 2nd groups made the transition to a combination of 0.5 mg E2/0.25 mg DRSP. The control group (n=59) of women not taking MGT. The duration of therapy is 1.0 (0.9; 1.2) years. The age of women was 56.8±1.6 years, 57.1±2.8 years and 57.3±1.7 years (p>0.05). Endothelium-dependent vasodilation (EDV) of the brachial artery, levels of endothelin-1 (ET-1), metabolites of nitric oxide (NO), asymmetric dimethylarginine (ADMA), von Willebrand factor antigen (vWF: Ag) in plasma were evaluated. Results In the control group EDV 8.6±5.1% of the original and 7.4±4.5% by the end of the study (p=0.08); in women of the 1st group 12.5±3.8% and 12.2±4.4; in women of the 2nd group11.1±8.5% and 10.5±0.2% (p=0.07 between women of the 1st and 2nd groups by the end of the study). The level of NO metabolites in women of the 1st group 43.4 (28.6; 45.9) at baseline and 40.7 (34.4; 41.5) μmol/l by the end of the study, in women of the 2nd group 38.8 (36.5; 44.9) and 35.2 (32.8; 38.9) μmol/l (p=0.04 between the women of the 1st and 2nd groups). In the control group 34.6 (30.4; 38.2) and 27.8 (24.5; 34.9) μmol/l (p<0.001 for women of the 1st and 2nd groups). In women of the 1st group a significant increase in ET-1 was detected from 1.02±0.26 initially to 1.18±0.24 fMol/ml by the end of the study; levels of vWF:Ag with 0.839 (0.695; 0.940) and 0.900 (0.782; 0.925) U/ml. The level of ADMA did not change significantly 0.43±0.10 and 0.45±0.10 μmol/L. In women of the 2nd group a significant increase ET-1 was detected from 1.08±0.42 to 1.29±0.59 fMol ml; vWF:Ag from 0.841 (0.718; 0.960) to 0.829 (0.811; 0.984) U/ml and ADMA from 0.43±0.10 to 0.48±0.15 μmol/l (p>0.05). In the the control group a significant increase in the level of ET-1 was observed from 1.40±0.43 to 1.74±0.34 fMol/ml by the end of the study; vWF levels:Ag 0.860 (0.743; 0.941) and 0.960 (0.850; 1.025) U/ml, ADMA 0.48±0.16 and 0.60±0.18 μmol/l (p<0.01 compared with women of the 1st and 2nd groups). Conclusions Revealed protective effects on endothelial function of ultra low-dose MHT in postmenopausal women. Early and prolonged MHT has an additional positive effect on the functional state of the vascular wall. Acknowledgement/Funding None

scholarly journals A119 AN EX VIVO MODEL TO STUDY THE GUT SEROTONERGIC SYSTEM RESPONSE TO LIVE AND HEAT-KILLED LACTOBACILLUS RHAMNOSUS STRAIN JB-1

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 138-140
Author(s):  
T Javkar ◽  
M Paul ◽  
A Stanisz ◽  
P Forsythe
Keyword(s):  
Gene Expression ◽  
Tryptophan Hydroxylase ◽  
Ex Vivo ◽  
Lactobacillus Rhamnosus ◽  
Monoamine Oxidase A ◽  
Serotonergic System ◽  
In Vivo Experiments ◽  
Mao A ◽  
Ec Cells

Abstract Background Enterochromaffin (EC) cells are one of the most abundant enteroendocrine cells in the intestinal epithelium, responsible for producing and storing the largest pool of serotonin or 5-hydroxytryptamine (5-HT) in the body. 5-HT has been shown to be important for modulating a large number of gastrointestinal reflexes in health and disease. 5-HT can stimulate extrinsic (vagal and spinal afferents) or intrinsic primary afferent neurons (IPANs) which are involved in motility, secretion and vasodilation within the intestines. Where EC cell localized enzyme tryptophan hydroxylase (TpH) isoform 1 is responsible for 5-HT synthesis, serotonin reuptake transporter (Sert) and monoamine oxidase A (Mao A) are responsible for termination by uptake and metabolism of 5-HT respectively. Our previous research has demonstrated the effects Lactobacillus rhamnosus (JB-1) on the firing frequency of spinal nerve fibres and motility. Increasing interest is being focused on potential health benefits of heat-inactivated microbes and purified bacterial components. However, the effect of these heat-killed bacteria on the intestinal epithelium cells, particularly on EC cells, is unknown. Aims Small intestinal organoids are shown to recapitulate in vivo characteristics of the small intestine epithelium. The present study aims to assess the suitability of intestinal organoids to study bacterial effects on the serotonergic system in the gut. Here we determined changes in the gene expression of key mediators in the serotonergic system [serotonin reuptake transporter (Sert), tryptophan hydroxylase-1 (Tph-1) and monoamine oxidase A (Mao A)] in response to live and heat-killed JB-1. Methods Male C57bl/6 mice aged 6–8 weeks were used for both ex vivo and in vivo experiments. Jejunal organoids were grown from whole crypts isolated using DTT-EDTA solution. Live and heat-killed JB-1 bacteria were used as treatments. Gene expression analysis was performed on jejunal organoids and jejunum tissue using qRT-PCR. Results JB-1 induced a significant increase in gene expression of Sert, Mao A and Tph-1. No significant difference was observed between the effects of live and heat-killed bacteria. In contrast the JB-1 increased expression of the peptide hormone CCK. Effects of JB-1 on gene expression in organoid culture were reflective of changes observed in in vivo experiments involving feeding of the bacteria. Conclusions Ex vivo organoid culture could be a useful tool in studying mechanisms underlying bacterial effects on serotonergic signalling. The observation that heat-killed bacteria produced comparable effects to the live organism suggests the possibility of isolating active 5-HT modulating components from these strains. Future research will focus on identifying such bacterial components and how their effects on gene expression influence serotonin availability Funding Agencies None

scholarly journals Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood

2017 ◽  
Vol 114 (13) ◽  
pp. 3509-3514 ◽  
Author(s):  
Yekta Dowlati ◽  
Arun V. Ravindran ◽  
Zindel V. Segal ◽  
Donna E. Stewart ◽  
Meir Steiner ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Depressed Mood ◽  
Mood Induction ◽  
Total Concentration ◽  
Monoamine Oxidase A ◽  
Control Group ◽  
Prevention Strategies ◽  
Open Label ◽  
Mao A ◽  
Shift Effect

Medical research is moving toward prevention strategies during prodromal states. Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with severe PPB strongly associated with an elevated risk for PPD. The most common complication of childbearing, PPD has a prevalence of 13%, but there are no widespread prevention strategies, and no nutraceutical interventions have been developed. To counter the effects of the 40% increase in monoamine oxidase A (MAO-A) levels that occurs during PPB, a dietary supplement kit consisting of monoamine precursor amino acids and dietary antioxidants was created. Key ingredients (tryptophan and tyrosine) were shown not to affect their total concentration in breast milk. The aim of this open-label study was to assess whether this dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the typical peak of PPB. Forty-one healthy women completed all study procedures. One group (n = 21) received the dietary supplement, composed of 2 g of tryptophan, 10 g of tyrosine, and blueberry juice with blueberry extract. The control group (n = 20) did not receive any supplement. PPB severity was quantitated by the elevation in depressed mood on a visual analog scale following the sad mood induction procedure (MIP). Following the MIP, there was a robust induction of depressed mood in the control group, but no effect in the supplement group [43.85 ± 18.98 mm vs. 0.05 ± 9.57 mm shift; effect size: 2.9; F(1,39) = 88.33, P < 0.001]. This dietary supplement designed to counter functions of elevated MAO-A activity eliminates vulnerability to depressed mood during the peak of PPB.

scholarly journals Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Dongmei Duan ◽  
Ya Tu ◽  
Xiuyan Yang ◽  
Ping Liu
Keyword(s):  
Molecular Mechanisms ◽  
Tryptophan Hydroxylase ◽  
Chronic Mild Stress ◽  
Monoamine Oxidase A ◽  
Synthesis Process ◽  
Mild Stress ◽  
Mao A ◽  
Antidepressant Efficacy ◽  
Hydroxyindoleacetic Acid ◽  
Behavior Of Rats

Objective.The current study is designed to investigate the antidepressant efficacy of electroacupuncture (EA) treatment by evaluating its effect on the synthesis, metabolism, reuptake, and receptors of 5-hydroxytryptamine (5-HT), so as to clarify the molecular mechanisms of EA for antidepression.Materials and Methods.Solitary combined with the chronic unpredictable mild stress (CUMS) was used to establish the rat model with depression. The depressed rats were supplied with EA treatment for 4 weeks, and the behavior change and the following indices including 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), monoamine oxidase A (MAO-A), tryptophan hydroxylase (TPH), 5-HT transporter (SERT), 5-HT1A, and 5-HT2A in hippocampus and prefrontal cortex were examined.Results.EA treatment significantly improved the behavior of rats and increased 5-HT level in hippocampus of depressed rats. Similarly, EA treatment could significantly increase protein and mRNA expression of TPH and 5-HT1A during 5-HT synthesis process in hippocampus of depressed rats. However, EA treatment had no effect on the activity of MAO-A and the expression of SERT protein and mRNA.Conclusion.Antidepressant efficacy of EA treatment can be accomplished through enhancing 5-HT synthesis, upregulating 5-HT1A level, and improving 5-HT content in brain and synaptic gaps.

Post-Stroke Fatigue May Be Associated with the Promoter Region of a Monoamine Oxidase A Gene Polymorphism

2016 ◽  
Vol 43 (1-2) ◽  
pp. 54-58 ◽  
Author(s):  
Smi Choi-Kwon ◽  
Mihye Ko ◽  
Sang-Eun Jun ◽  
Juhan Kim ◽  
Kyung-Hee Cho ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Promoter Region ◽  
Tryptophan Hydroxylase ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Monoamine Oxidase A ◽  
Potential Contribution ◽  
Female Patients ◽  
Post Stroke ◽  
Mao A

Background: Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. Methods: A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70°C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A). Results: Among the 373 patients, 164 (44%) had PSF. All patients were ethnic Koreans. Of the 6 polymorphisms examined, only one marker, that is, low-activity MAO-A was associated with PSF (p < 0.05) in female patients. Multiple logistic regression analyses showed that post-stroke depression (PSD; 95% CI 1.561-14.323, p = 0.006) and low MAO-A activity (95% CI 0.166-0.722, p = 0.005) were factors associated with PSF in female patients, whereas only PSD (95% CI 5.511-65.269, p = 0.000) was associated with PSF in male patients. Conclusions: Our findings suggest that PSF may be associated with a genetic polymorphism involving MAO-A, at least in female stroke patients.

scholarly journals PENGARUH AROMATERAPI LAVENDER TERHADAP KECEMASAN IBU BERSALIN

2021 ◽  
Vol 7 (4) ◽  
pp. 785-792
Author(s):  
Istiqomah Mirazanah ◽  
Bunga Tiara Carolin ◽  
Sri Dinengsih
Keyword(s):  
Rating Scale ◽  
T Test ◽  
Psychological Disorder ◽  
Maternal Anxiety ◽  
Control Group ◽  
Average Difference ◽  
Control Group Design ◽  
Group Design ◽  
The Impact ◽  
Hamilton Rating Scale

Background: During the first stage of labor, a woman will experience a psychological disorder, namely anxiety, the impact will cause muscle tension in the body, the birth canal becomes stiff, hard and difficult to expand resulting in the labor process not going smoothly. The main content in lavender oil is linalool acetate which can relax and relax the working system of the nerves and tense muscles.Objective: This study aims to determine the effect of lavender aromatherapy on maternal anxiety at RSU Kota Tangerang Selatan in 2021.Methodology: This quasi-experimental study used a pretest and posttest design with a control group design. The sample in this study amounted to 30 mothers who will give birth at RSU Kota Tangerang Selatan with 15 respondents each. The sampling technique used total sampling. The research instrument used the Hamilton Rating Scale for Anxienty (HRS-A) questionnaire. Data were analyzed using the Independent T-test, which previously tested for normality and homogeneity.Results: The results of the study on anxiety before being given lavender aromatherapy an average of of 22.47 and after being given lavender aromatherapy an average of 18.33 with an average difference of 4.14, in the control group examination I an average of 22.60 and examination II an average 22.27 with an average difference of 0.33 and the effect of lavender aromatherapy on maternal anxiety with a significance level of 0.001.Conclusions: There is an effect of lavender aromatherapy on maternal anxiety at RSU Kota Tangerang Selatan in 2021.Suggestion  It is hoped that lavender aromatherapy can be applied as a whole in Indonesian health services..Keywords: Anxiety, Maternal Lavender Aromatherapy,  ABSTRAK  Latar Belakang: Persalinan akan menyebabkan gangguan psikologi berupa kecemasan yang dapat mengakibatkan penurunan aliran darah yang membawa oksigen ke rahim dan janin sehingga dapat terjadi hal-hal yang merugikan bagi ibu dan janin. Salah satu terapi non-farmakologis untuk menurunkan kecemasan adalah melalui pemberian aromaterapi khususnya aromaterapi lavender dapat memberi rasa tenang, sehingga dapat digunakan sebagai manajemen stres.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh aromaterapi lavender terhadap kecemasan ibu bersalin di RSU Kota Tangerang Selatan Tahun 2021.Metodologi: Penelitian quasi eksperimental ini menggunakan rancangan pretest and posttest with control group design. Sampel dalam penelitian ini berjumlah 30 ibu yang akan melahirkan di RSU Kota Tangerang Selatan dengan masing-masing kelompok 15 responden. Teknik pengambilan sampel menggunakan total sampling. Instrumen penelitian menggunakan kesioner Hamilton Rating Scale for Anxienty (HRS-A). Data dianalisis menggunakan T-test Independent yang sebelumnya dilakukan uji normalitas dan homogenitas.Hasil Penelitian: Hasil penelitian terhadap kecemasan sebelum diberikan aromaterapi lavender rata-rata 22,47 dan sesudah diberikan aromaterapi lavender rata-rata 18,33 dengan selisih rata-rata 4,14, pada kelompok kontrol pemeriksaan I rata-rata 22,60 dan pemeriksaan II rata-rata 22,27 dengan selisih rata-rata 0,33. Terdapat perbedaan rerata skor tingkat kecemasan yang bermakna antara kelompok intervensi dan kelompok kontrol dengan tingkat signifikansi 0,001 < 0,05. Simpulan: Terdapat pengaruh aromaterapi lavender terhadap kecemasan ibu bersalin di RSU Kota Tangerang Selatan Tahun 2021.Saran Diharapkan pemberian aromaterapi lavender dapat diterapkan secara menyeluruh dipelayanan kesehatan Indonesia. Kata Kunci : Aromaterapi Lavender, ibu bersalin, kecemasan  

scholarly journals Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study

10.2196/17341 ◽  
2020 ◽  
Vol 7 (12) ◽  
pp. e17341
Author(s):  
Luca Cerniglia ◽  
Silvia Cimino ◽  
Eleonora Marzilli ◽  
Esterina Pascale ◽  
Renata Tambelli
Keyword(s):  
Young Adults ◽  
Family Functioning ◽  
Genetic Polymorphisms ◽  
Internet Addiction ◽  
Exploratory Study ◽  
Monoamine Oxidase A ◽  
Self Report ◽  
Control Group ◽  
Factors Associated ◽  
Mao A

Background International research has emphasized that youths are at higher risk for the onset of internet addiction (IA), but studies investigating biological, psychological, and social factors associated with this condition are limited. Objective This study aims to investigate the possible association between IA and genetic polymorphisms in monoamine oxidase A (MAO-A), serotonin-transporter (5-HTTPR), dopamine receptor (DRD4), and dopamine transporter (DAT1) genes by considering the role played by the perception of young adults in their family functioning and their depression, anxiety, and avoidant personality problems. Methods In a sample of 104 male and female young adults aged between 19 and 23 years (mean age 21.87, SD 2.29 years) recruited from universities in the central southern part of Italy, we addressed the presence of IA using the Young criteria of the IA test. Moreover, the perception of young adults of their family functioning and their psychopathological symptoms were assessed through the Family Assessment Device (FAD) and the Adult Self-Report, respectively. Results We found no significant association between IA and any genetic polymorphisms, neither among males or females. Young adults with IA reported significantly higher scores in the subscale of FAD affective responsiveness (AR; P=.01) and in depressive problems (P=.02), anxiety problems (P=.009), and avoidant personality problems (P=.003) than those in the control group. Results of mediation analyses showed a mediation role played by depressive symptoms (B=0.99; 95% CI 0.22 to 1.97) and avoidant personality problems (B=1.09; 95% CI 0.32 to 2.05) of young adults on the relationship between the FAD, AR, and IA. Finally, this relationship was moderated by the genotype of the 5-HTTLPR (P<.001), DAT1 (P<.001), and MAO-A (P<.001) genes in young adults. Conclusions This exploratory study supports the recent evidence on the mutual relationship among biological, individual, and social risk factors associated with IA in young adulthood. Our findings may have important clinical implications for the development of prevention and treatment programs.

scholarly journals Serum Liver Proteins and 17

2019 ◽  
Author(s):  
Zahra Tahmasebi Fard ◽  
Fatemeh Rouhollah ◽  
Nahid Nafisi
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Liver Enzymes ◽  
Sex Hormone Binding Globulin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Cancer Group ◽  
17Β Estradiol ◽  
The Mean

Background: Breast cancer is a hormone-dependent malignancy that is associated with estrogen and progesterone interactions. The liver is the most important organ to be affected by the metastasis of breast cancer, which causes functional impairment. Aim: We compared levels of obesity, 17β-estradiol, and secreted proteins in postmenopausal women with breast cancer but without hepatic symptoms to those in healthy postmenopausal women. Materials and Methods: We recruited 105 postmenopausal women with breast cancer but without any clinical hepatic symptoms based on a physician’s diagnosis, and 105 healthy postmenopausal women. After taking blood samples, we separated the serum and determined the levels of alanine aminotransferase (ALT), enzyme aspartate aminotransferase (AST), sex hormone-binding globulin (SHBG), and 17β-estradiol using an enzyme-linked immunosorbent assay (ELISA). The results were statistically analyzed using SPSS. Results: The mean ages of the subjects in the cancer and control groups were 60.88 ± 0.85 and 55.56 ± 0.81 years, respectively. The exception ages (p=0.002), body mass index (BMI) values (p=0.033), serum glutamic oxaloacetic transaminase (SGOT) levels/AST levels (p=3.1*10−4), serum glutamic pyruvic transaminase (SGPT) levels/ALT levels(p=0.001), SHBG levels(p=0.014), and 17β-estradiol levels(p=0.003) in the serum differed significantly between the groups. Moreover, the mean serum 17β-estradiol (E2) levels and weights were higher in the cancer group than in the control group. Nevertheless, the mean serum levels of synthetic liver enzymes (SHBG, ALT, and AST) were lower in the cancer group than in the control group. Conclusion: In general, the postmenopausal cancer patients had higher serum estrogen levels and BMIs than their healthy counterparts. Furthermore, the levels of liver enzymes apparently decreased in the cancer group, probably owing to liver malfunction.

scholarly journals The Effectiveness of Lifestyle Educational Program in Health Promoting Behaviors and Menopausal Symptoms in 45-60-Year-Old Women in Marvdasht, Iran

2016 ◽  
Vol 8 (10) ◽  
pp. 34 ◽  
Author(s):  
Mahin Nazari ◽  
Samaneh Farmani ◽  
Mohammad Hosein Kaveh ◽  
Haleh Ghaem
Keyword(s):  
Postmenopausal Women ◽  
Rating Scale ◽  
T Test ◽  
Menopausal Symptoms ◽  
Control Group ◽  
Health Promoting Behaviors ◽  
Significant Difference ◽  
Health Promoting ◽  
Health Promoting Lifestyle ◽  
Paired T Test

<p><strong>Introduction: </strong>Health and lifestyle of women are of great importance in some periods of life, such as menopause. Since postmenopausal women are considered as a vulnerable group of the society, finding a strategy to improve their health seems necessary.</p><p><strong>Methods:</strong> This experimental study with pretest-posttest design was carried out on 200 postmenopausal women between 45 and 60 years old in Ramjerd, Marvdasht, Iran, in 2014. The women who met the inclusion criteria of the study were selected by simple random sampling. The data were collected using demographic information questionnaire, Menopause Rating Scale (MRS), and Walker’s Health Promoting Lifestyle Profile (HPLP<strong>II</strong>). The data were entered into the SPSS statistical software (version 19) and were analyzed using descriptive statistics, paired t-test, independent t-test, and chi-square test. P-values less than 0.05 were considered as statistically significant.</p><p><strong>Results:</strong> The results of paired t-test showed a significant difference in the mean scores of health promoting lifestyle and MRS in the experimental group (P&lt;.05), but not in the control group (P&gt;.05).</p><p><strong>Conclusion:</strong> Lifestyle education was effective in health promoting behaviors and menopausal symptoms. After the educational intervention, health promoting behaviors increased and menopausal symptoms decreased in the postmenopausal women. Therefore, educational interventions based on health promoting lifestyles can be used as an appropriate strategy to reduce postmenopausal women’s menopausal symptoms and improve their health.<strong></strong></p>

scholarly journals Decreased Npas4 expression in patients with post-stroke depression

2019 ◽  
Vol 7 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Shina Gu ◽  
Xiaodan Li ◽  
Lin Zhao ◽  
Huicong Ren ◽  
Chendi Pei ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Mononuclear Cells ◽  
Rating Scale ◽  
Control Group ◽  
Peripheral Blood Mononuclear ◽  
Post Stroke ◽  
Stroke Group ◽  
Post Stroke Depression ◽  
Hamilton Rating Scale

Purpose:Post-stroke depression (PSD) is a frequent neuropsychiatric disorder following stroke which is associated with poor outcome. Neuronal Per-Arnt-Sim (PAS) domain protein 4 (Npas4) is associated with cognitive function. Npas4 expression in peripheral blood mononuclear cells (PBMCs) from patients with PSD was measured to find new therapeutic strategy.Patients and methods:Ischemic stroke patients (n = 152) within 1 week of stroke onset were recruited. At 3 months follow-up, the patients were divided into a PSD group (n = 77) and a stroke group (n = 75) using the Hamilton Rating Scale. Healthy subjects (n = 75) were also recruited in the study. The PSD group received 12 weeks of duloxetine treatment. Cognitive function was evaluated using the P300 test. Npas4 expression in PBMCs was measured by quantitative RT-PCR (qPCR).Results:Before treatment, P300 latencies in the PSD group were prolonged and the P300 amplitudes were lower than the control group (P < 0.01). Npas4 expression in the PSD group was also lower than the control group (P < 0.01). After treatment, the P300 latencies were reduced and the amplitudes were significantly elevated in the PSD group compared to that before treatment (P < 0.01). Meanwhile, Npas4 levels were significantly higher than that before treatment (P < 0.01). Npas4 expression was positively correlated to the P300 amplitudes (P < 0.05).Conclusion:Changes of Npas4 expression in PBMCs are associated with cognitive impairment in PSD patients and new therapeutic options applying Npas4-related transcript mechanism could be considered in the future.

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