scholarly journals Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export

2010 ◽  
Vol 91 (5) ◽  
pp. 1290-1301 ◽  
Author(s):  
E. K. C. Read ◽  
P. Digard
Keyword(s):  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Virus Mrnas

scholarly journals Nuclear Export of Influenza A Virus mRNAs Requires Ongoing RNA Polymerase II Activity

Traffic ◽  
2006 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Maria-Joao Amorim ◽  
Eliot K. Read ◽  
Rosa M. Dalton ◽  
Liz Medcalf ◽  
Paul Digard
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Virus Mrnas

scholarly journals Chenodeoxycholic Acid from Bile Inhibits Influenza A Virus Replication via Blocking Nuclear Export of Viral Ribonucleoprotein Complexes

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3315 ◽  
Author(s):  
Ling Luo ◽  
Weili Han ◽  
Jinyan Du ◽  
Xia Yang ◽  
Mubing Duan ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Chenodeoxycholic Acid ◽  
Nuclear Export ◽  
Influenza A ◽  
Antiviral Agent ◽  
Dietary Fats ◽  
Lipid Mediator ◽  
Omega 3 ◽  
Ribonucleoprotein Complexes

Influenza A virus (IAV) infection is still a major global threat for humans, especially for the risk groups: young children and the elderly. The currently licensed antiviral drugs target viral factors and are prone to viral resistance. In recent years, a few endogenous small molecules from host, such as estradiol and omega-3 polyunsaturated fatty acid (PUFA)-derived lipid mediator protection D1 (PD1), were demonstrated to be capable of inhibiting IAV infection. Chenodeoxycholic acid (CDCA), one of the main primary bile acids, is synthesized from cholesterol in the liver and classically functions in emulsification and absorption of dietary fats. Clinically, CDCA has been used in the treatment of patients with cholesterol gallstones for more than five decades. In this study, we showed that CDCA attenuated the replication of three subtypes of influenza A virus, including a highly pathogenic H5N1 strain, in A549 and MDCK cell cultures with IC50 ranging from 5.5 to 11.5 μM. Mechanistically, CDCA effectively restrained the nuclear export of viral ribonucleoprotein (vRNP) complexes. In conclusion, as an endogenous physiological small molecule, CDCA can inhibit IAV replication in vitro, at least in part, by blocking vRNP nuclear export, and affords further studies for development as a potential antiviral agent against IAV infections.

scholarly journals A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 337
Author(s):  
Juliann Nzembi Makau ◽  
Ken Watanabe ◽  
Hiroki Otaki ◽  
Satoshi Mizuta ◽  
Takeshi Ishikawa ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Drug Resistant ◽  
In Silico Screening ◽  
Antiviral Compound ◽  
Escape Mutants ◽  
2009 H1n1 ◽  
Emergence Of Resistance ◽  
Selection Of

The emergence of resistance to currently available anti-influenza drugs has heightened the need for antivirals with novel mechanisms of action. The influenza A virus (IAV) nucleoprotein (NP) is highly conserved and essential for the formation of viral ribonucleoprotein (vRNP), which serves as the template for replication and transcription. Recently, using in silico screening, we identified an antiviral compound designated NUD-1 (a 4-hydroxyquinolinone derivative) as a potential inhibitor of NP. In this study, we further analyzed the interaction between NUD-1 and NP and found that the compound interferes with the oligomerization of NP, which is required for vRNP formation, leading to the suppression of viral transcription, protein synthesis, and nuclear export of NP. We further assessed the selection of resistant variants by serially passaging a clinical isolate of the 2009 H1N1 pandemic influenza virus in the presence of NUD-1 or oseltamivir. NUD-1 did not select for resistant variants after nine passages, whereas oseltamivir selected for resistant variants after five passages. Our data demonstrate that NUD-1 interferes with the oligomerization of NP and less likely induces drug-resistant variants than oseltamivir; hence, it is a potential lead compound for the development of novel anti-influenza drugs.

scholarly journals Characteristics of Nucleocytoplasmic Transport of H1N1 Influenza A Virus Nuclear Export Protein

2014 ◽  
Vol 88 (13) ◽  
pp. 7455-7463 ◽  
Author(s):  
S. Gao ◽  
S. Wang ◽  
S. Cao ◽  
L. Sun ◽  
J. Li ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Nucleocytoplasmic Transport ◽  
Nuclear Export Protein ◽  
Export Protein

scholarly journals Sorting of influenza A virus RNA genome segments after nuclear export

Virology ◽  
2010 ◽  
Vol 401 (2) ◽  
pp. 248-256 ◽  
Author(s):  
Naoki Takizawa ◽  
Michiko Kumakura ◽  
Kaoru Takeuchi ◽  
Nobuyuki Kobayashi ◽  
Kyosuke Nagata
Keyword(s):  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Virus Rna ◽  
Rna Genome

scholarly journals CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2

2014 ◽  
Vol 72 (5) ◽  
pp. 971-982 ◽  
Author(s):  
Yong Hu ◽  
Xiaokun Liu ◽  
Anding Zhang ◽  
Hongbo Zhou ◽  
Ziduo Liu ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A

scholarly journals Reply to “Nuclear Export Signal and Immunodominant CD8+T Cell Epitope in Influenza A Virus Matrix Protein 1”

2012 ◽  
Vol 86 (18) ◽  
pp. 10259-10260
Author(s):  
Shuai Cao ◽  
Yi Shi ◽  
Shuguang Tan ◽  
Hao Song ◽  
George F. Gao ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Matrix Protein ◽  
Nuclear Export Signal ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Export Signal
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