scholarly journals Roles of Agrobacterium tumefaciens C58 ZntA and ZntB and the transcriptional regulator ZntR in controlling Cd2+/Zn2+/Co2+ resistance and the peroxide stress response

Microbiology ◽  
2015 ◽  
Vol 161 (9) ◽  
pp. 1730-1740 ◽  
Author(s):  
Paweena Chaoprasid ◽  
Sumontha Nookabkaew ◽  
Rojana Sukchawalit ◽  
Skorn Mongkolsuk
Keyword(s):  
Stress Response ◽  
Agrobacterium Tumefaciens ◽  
Transcriptional Regulator ◽  
Agrobacterium Tumefaciens C58 ◽  
Peroxide Stress

NieR is the repressor of a NaOCl-inducible efflux system in Agrobacterium tumefaciens C58

2021 ◽  
pp. 126816
Author(s):  
Jintana Duang-Nkern ◽  
Benya Nontaleerak ◽  
Tham Udomkanarat ◽  
Kritsakorn Saninjuk ◽  
Rojana Sukchawalit ◽  
...  
Keyword(s):  
Agrobacterium Tumefaciens ◽  
Efflux System ◽  
Agrobacterium Tumefaciens C58

An AraC/XylS Family Transcriptional Regulator Modulates the Oxidative Stress Response of Francisella tularensis

2021 ◽  
Author(s):  
Dina Marghani ◽  
Zhuo Ma ◽  
Anthony J. Centone ◽  
Weihua Huang ◽  
Meenakshi Malik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Francisella Tularensis ◽  
Human Disease ◽  
Transcriptional Regulator ◽  
Intracellular Survival ◽  
Gram Negative ◽  
Expression Of Genes ◽  
Transcription Regulators

Francisella tularensis is a Gram-negative bacterium that causes a fatal human disease known as tularemia. The Centers for Disease Control have classified F. tularensis as Category A Tier-1 Select Agent. The virulence mechanisms of Francisella are not entirely understood. Francisella possesses very few transcription regulators, and most of these regulate the expression of genes involved in intracellular survival and virulence. The F. tularensis genome sequence analysis reveals an AraC ( FTL_ 0689) transcriptional regulator homologous to the AraC/XylS family of transcriptional regulators. In Gram-negative bacteria, AraC activates genes required for L-arabinose utilization and catabolism. The role of the FTL_ 0689 regulator in F. tularensis is not known. In this study, we characterized the role of FTL_ 0689 in gene regulation of F. tularensis and investigated its contribution to intracellular survival and virulence. The results demonstrate that FTL_0689 in Francisella is not required for L-arabinose utilization. Instead, FTL_ 0689 specifically regulates the expression of the oxidative and global stress response, virulence, metabolism, and other key pathways genes required by Francisella when exposed to oxidative stress. The FTL_0689 mutant is attenuated for intramacrophage growth and virulence in mice. Based on the deletion mutant phenotype, FTL_0689 was termed osrR ( o xidative s tress r esponse r egulator). Altogether, this study elucidates the role of the osrR transcriptional regulator in tularemia pathogenesis. IMPORTANCE: The virulence mechanisms of category A select agent Francisella tularensis , the causative agent of a fatal human disease known as tularemia, remain largely undefined. The present study investigated the role of a transcriptional regulator and its overall contribution to the oxidative stress resistance of F. tularensis . The results provide an insight into a novel gene regulatory mechanism, especially when Francisella is exposed to oxidative stress conditions. Understanding such Francisella - specific regulatory mechanisms will identify potential targets for developing effective therapies and vaccines to prevent tularemia.

scholarly journals Induction of Repair Capacity for Oxidatively Damaged DNA as a Component of Peroxide Stress Response in Escherichia coli.

1996 ◽  
Vol 37 (3) ◽  
pp. 171-176 ◽  
Author(s):  
QIU-MEI ZHANG ◽  
TADASHI TAKEMOTO ◽  
SEIJI MITO ◽  
SHUJI YONEI
Keyword(s):  
Escherichia Coli ◽  
Stress Response ◽  
Repair Capacity ◽  
Peroxide Stress ◽  
Damaged Dna

The role of thiol redox systems in the peroxide stress response of Escherichia coli

Microbiology ◽  
2007 ◽  
Vol 76 (6) ◽  
pp. 669-675
Author(s):  
O. N. Oktyabrskii ◽  
N. G. Muzyka ◽  
V. Yu. Ushakov ◽  
G. V. Smirnova
Keyword(s):  
Escherichia Coli ◽  
Stress Response ◽  
Redox Systems ◽  
Thiol Redox ◽  
Peroxide Stress

scholarly journals Different Regulation and Roles of Lactonases AiiB and AttM in Agrobacterium tumefaciens C58

2009 ◽  
Vol 22 (5) ◽  
pp. 529-537 ◽  
Author(s):  
Elise Haudecoeur ◽  
Mélanie Tannières ◽  
Amélie Cirou ◽  
Aurélie Raffoux ◽  
Yves Dessaux ◽  
...  
Keyword(s):  
Agrobacterium Tumefaciens ◽  
Selective Advantage ◽  
In Planta ◽  
Host Interaction ◽  
Plant Tumors ◽  
Plant Signals ◽  
Polymerase Chain ◽  
Agrobacterium Tumefaciens C58 ◽  
Regulated Functions

The phytopathogen Agrobacterium tumefaciens C58 expresses two lactonases, AttM and AiiB. We showed that expression of the aiiB gene was controlled by agrocinopines A and B and required the agrocinopine-ABC transporter Acc, but was not affected by the level of quorum-sensing (QS) signal 3-oxo-octanoylhomoserine lactone (OC8-HSL). In the presence of agrocinopines, a constructed aiiB mutant accumulated OC8-HSL at a level 10-fold higher than that of the wild-type strain, and showed an exacerbated expression of a key QS-regulated function, conjugation of Ti plasmid (in vitro and in planta), as well as an increase of the number of emerging tumors on the host plant. The expression and acyl-HSL-degrading activity of AttM were evident in the presence of wounded tissues; however, in unwounded plant tumors, the QS-regulated functions were weakly affected in an attM mutant. By contrast, we observed that attM conferred a selective advantage in the course of colonization of plant tumors. Finally, polymerase chain reaction survey of genes attM and aiiB showed that they were not strictly conserved in the genus Agrobacterium. This work proved that the lactonases AttM and AiiB are regulated by different plant signals and are implicated in different functions in the course of the A. tumefaciens C58–host interaction.

Regulation and function of the flavonoid-inducible efflux system, emrR-emrAB, in Agrobacterium tumefaciens C58

2019 ◽  
Vol 103 (14) ◽  
pp. 5763-5780 ◽  
Author(s):  
Sasimaporn Khemthong ◽  
Puttamas Nuonming ◽  
Thanittra Dokpikul ◽  
Rojana Sukchawalit ◽  
Skorn Mongkolsuk
Keyword(s):  
Agrobacterium Tumefaciens ◽  
Efflux System ◽  
Agrobacterium Tumefaciens C58 ◽  
And Function
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