scholarly journals Genomic and structural features of the yellow fever virus from the 2016–2017 Brazilian outbreak

2018 ◽  
Vol 99 (4) ◽  
pp. 536-548 ◽  
Author(s):  
Mariela Martínez Gómez ◽  
Filipe Vieira Santos de Abreu ◽  
Alexandre Araujo Cunha dos Santos ◽  
Iasmim Silva de Mello ◽  
Marta Pereira Santos ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Structural Features ◽  
Fever Virus

scholarly journals Genomic and structural features of the Yellow Fever virus from the 2016-2017 Brazilian outbreak

2017 ◽  
Author(s):  
Mariela Martínez Gómez ◽  
Filipe Vieira Santos de Abreu ◽  
Alexandre Araujo Cunha dos Santos ◽  
Iasmim Silva de Mello ◽  
Marta Pereira Santos ◽  
...  
Keyword(s):  
Amino Acid ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Viral Proteins ◽  
Structural Features ◽  
Fever Virus ◽  
Viral Fitness ◽  
And Function ◽  
Enzyme Structure And Function ◽  
Unique Amino Acid

ABSTRACTBrazil has been suffering a severe sylvatic epidemic of yellow fever virus (YFV) since late 2016. Analysis of full-length YFV genomes from all hosts involved in the Brazilian 2017 outbreak reveals that they belong to sub-lineage 1E within modern-lineage, but display several unique amino acid substitutions in highly conserved positions at NS3 and NS5 viral proteins. Evolutionary analyses indicate that YFV carrying that set of amino acid substitution circulates in the Southern Brazilian region for several months before being detected in December 2016. Structural and selection analyses support that some of these substitutions were under positive selection and could impact enzyme structure and function. Altogether, this evidence demonstrated that the current Brazilian YFV carries unique amino acid signatures in the non-structural proteins and support the hypothesis that those substitutions may be affecting the viral fitness and transmissibility.

scholarly journals Yellow fever virus outbreak in Brazil under current and future climate

2021 ◽  
Vol 6 ◽  
pp. 664-677
Author(s):  
Tara Sadeghieh ◽  
Jan M. Sargeant ◽  
Amy L. Greer ◽  
Olaf Berke ◽  
Guillaume Dueymes ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Future Climate

scholarly journals Yellow Fever Outbreak in Eastern Senegal, 2020–2021

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1475
Author(s):  
Moussa Moïse Diagne ◽  
Marie Henriette Dior Ndione ◽  
Alioune Gaye ◽  
Mamadou Aliou Barry ◽  
Diawo Diallo ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Mosquito Species ◽  
Virus Transmission ◽  
Genomic Analysis ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
World Health ◽  
Effective Vaccine ◽  
Ministry Of Health

Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3′UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.

YELLOW FEVER VIRUS

1929 ◽  
Vol 92 (7) ◽  
pp. 550 ◽  
Author(s):  
HENRIQUE DE BEAUREPAIRE ARAGÃO
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213

1995 ◽  
Vol 35 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Claudia N. Duarte dos Santos ◽  
Paulo R. Post ◽  
Ricardo Carvalho ◽  
Idevaldo I. Ferreira ◽  
Charles M. Rice ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Yellow Fever ◽  
Virus Vaccine ◽  
Complete Nucleotide Sequence ◽  
Yellow Fever Virus ◽  
Fever Virus

Isolation of Yellow Fever Virus from Nulliparous Haemagogus (Haemagogus) janthinomys in Eastern Amazonia

2002 ◽  
Vol 2 (1) ◽  
pp. 47-50 ◽  
Author(s):  
B. Mondet ◽  
P.F.C. Vasconcelos ◽  
A.P.A. Travassos da Rosa ◽  
E.S. Travassos da Rosa ◽  
S.G. Rodrigues ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

scholarly journals A DNA Vaccine against Yellow Fever Virus: Development and Evaluation

2015 ◽  
Vol 9 (4) ◽  
pp. e0003693 ◽  
Author(s):  
Milton Maciel ◽  
Fábia da Silva Pereira Cruz ◽  
Marli Tenório Cordeiro ◽  
Márcia Archer da Motta ◽  
Klécia Marília Soares de Melo Cassemiro ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

scholarly journals Using next generation sequencing to identify yellow fever virus in Uganda

Virology ◽  
2012 ◽  
Vol 422 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Laura K. McMullan ◽  
Mike Frace ◽  
Scott A. Sammons ◽  
Trevor Shoemaker ◽  
Stephen Balinandi ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Next Generation ◽  
Generation Sequencing
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