scholarly journals Reinstating Mycobacterium massiliense and Mycobacterium bolletii as species of the Mycobacterium abscessus complex

2017 ◽  
Vol 67 (8) ◽  
pp. 2726-2730 ◽  
Author(s):  
Toidi Adekambi ◽  
Mohamed Sassi ◽  
Jakko van Ingen ◽  
Michel Drancourt
Keyword(s):  
Mycobacterium Abscessus ◽  
Mycobacterium Massiliense ◽  
Mycobacterium Abscessus Complex ◽  
As Species ◽  
Mycobacterium Bolletii

scholarly journals Support from Phylogenomic Networks and Subspecies Signatures for Separation of Mycobacterium massiliense from Mycobacterium bolletii

2015 ◽  
Vol 53 (9) ◽  
pp. 3042-3046 ◽  
Author(s):  
Joon Liang Tan ◽  
Yun Fong Ngeow ◽  
Siew Woh Choo
Keyword(s):  
Amino Acid ◽  
Mycobacterium Abscessus ◽  
Clinical Implications ◽  
Content Type ◽  
Mycobacterium Massiliense ◽  
Protein Signatures ◽  
Mycobacterium Bolletii

Mycobacterium abscessussubspecies classification has important clinical implications. We used phylogenomic network and amino acid analyses to provide evidence for the separation ofMycobacterium bolletiiandMycobacterium massilienseinto two distinct subspecies which can potentially be differentiated rapidly by their protein signatures.

scholarly journals A Novel Gene, erm(41), Confers Inducible Macrolide Resistance to Clinical Isolates of Mycobacterium abscessus but Is Absent from Mycobacterium chelonae

2009 ◽  
Vol 53 (4) ◽  
pp. 1367-1376 ◽  
Author(s):  
Kevin A. Nash ◽  
Barbara A. Brown-Elliott ◽  
Richard J. Wallace
Keyword(s):  
Deletion Mutant ◽  
Mycobacterium Abscessus ◽  
Macrolide Resistance ◽  
Clinical Isolates ◽  
Type Ii ◽  
Mycobacterium Chelonae ◽  
Resistance Phenotype ◽  
Inducible Resistance ◽  
Mycobacterium Massiliense ◽  
Mycobacterium Bolletii

ABSTRACT Mycobacterium abscessus infections tend to respond poorly to macrolide-based chemotherapy, even though the organisms appear to be susceptible to clarithromycin. Circumstantial evidence suggested that at least some M. abscessus isolates might be inducibly resistant to macrolides. Thus, the purpose of this study was to investigate the macrolide phenotype of M. abscessus clinical isolates. Inducible resistance to clarithromycin (MIC > 32 μg/ml) was found for 7 of 10 clinical isolates of M. abscessus previously considered susceptible; the remaining 3 isolates were deemed to be susceptible (MIC ≤ 0.5 μg/ml). Inducible resistance was conferred by a novel erm gene, erm(41), which was present in all 10 isolates and in an isolate of Mycobacterium bolletii (M. abscessus type II). However, the erm(41) alleles were nonfunctional in the three susceptible M. abscessus isolates. No evidence of erm(41) was found in Mycobacterium chelonae, and an isolate of Mycobacterium massiliense appeared to be an erm(41) deletion mutant. Expression of erm(41) in M. abscessus conferred resistance to clarithromycin and erythromycin and the ketolide HMR3004. However, this species was found to be intrinsically resistant, independent of erm(41), to clindamycin, quinupristin (streptogramin B), and telithromycin. The ability to confer resistance to clindamycin and telithromycin, but not quinupristin, was demonstrated by expressing erm(41) in Maycobacterium smegmatis. Exposure of M. abscessus to the macrolide-lincosamide-streptogramin B-ketolide agents increased the levels of erm(41) mRNA 23- to 250-fold within 24 h. The inducible macrolide resistance phenotype of some M. abscessus isolates may explain the lack of efficacy of macrolide-based chemotherapy against this organism.

scholarly journals Proposal that Mycobacterium massiliense and Mycobacterium bolletii be united and reclassified as Mycobacterium abscessus subsp. bolletii comb. nov., designation of Mycobacterium abscessus subsp. abscessus subsp. nov. and emended description of Mycobacterium abscessus

2011 ◽  
Vol 61 (9) ◽  
pp. 2311-2313 ◽  
Author(s):  
Sylvia Cardoso Leao ◽  
Enrico Tortoli ◽  
Jean Paul Euzéby ◽  
Maria Jesus Garcia
Keyword(s):  
Mycobacterium Abscessus ◽  
Mycobacterium Massiliense ◽  
Emended Description ◽  
Mycobacterium Bolletii

The names ‘Mycobacterium abscessus subsp. abscessus’ and ‘Mycobacterium abscessus subsp. massiliense’, proposed by Leao et al. (2009, J Clin Microbiol 47, 2691–2698), cannot be validly published. The purpose of this report is to provide a description in accordance with the Rules of the Bacteriological Code (1990 Revision). Moreover, the proposal of the name ‘Mycobacterium abscessus subsp. massiliense’ is contrary to Rule 38 and the correct name of this taxon, at the rank of subspecies, is Mycobacterium abscessus subsp. bolletii comb. nov. A description of Mycobacterium abscessus subsp. abscessus subsp. nov. and an emended description of Mycobacterium abscessus are also given.

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