scholarly journals Importance of the matriline for genomic imprinting, brain development and behaviour

2013 ◽  
Vol 368 (1609) ◽  
pp. 20110327 ◽  
Author(s):  
E. B. Keverne
Keyword(s):  
Brain Development ◽  
Mammalian Brain ◽  
Cultural Learning ◽  
Imprinted Genes ◽  
Synaptic Connections ◽  
Placental Development ◽  
Short Term ◽  
Knowledge Based ◽  
Evolutionary Origins

Mammalian brain development commences during foeto-placental development and is strongly influenced by the epigenetic regulation of imprinted genes. The foetal placenta exerts considerable influence over the functioning of the adult maternal hypothalamus, and this occurs at the same time as the foetus itself is developing a hypothalamus. Thus, the action and interaction of two genomes in one individual, the mother, has provided a template for co-adaptive functions across generations that are important for maternal care and resource transfer, while co-adaptively shaping the mothering capabilities of each subsequent generation. The neocortex is complex, enabling behavioural diversity and cultural learning such that human individuals are behaviourally unique. Retrotransposons may, in part, be epigenetic mediators of such brain diversity. Interestingly some imprinted genes are themselves retrotransposon-derived, and retrotransposon silencing by DNA methylation is thought to have contributed to the evolutionary origins of imprint control regions. The neocortex has evolved to be adaptable and sustain both short-term and long-term synaptic connections that underpin learning and memory. The adapted changes are not themselves inherited, but the predisposing mechanisms for such epigenetic changes are heritable. This provides each generation with the same ability to make new adaptations while constrained by a transgenerational knowledge-based predisposition to preserve others.

scholarly journals The Influence of the Knowledge-Based Network Structure Hole on Enterprise Innovation Performance: The Threshold Effect of R&D Investment Intensity

2020 ◽  
Vol 12 (15) ◽  
pp. 6155
Author(s):  
Jiajia Hao ◽  
Chunling Li ◽  
Runsen Yuan ◽  
Masood Ahmed ◽  
Muhammad Asif Khan ◽  
...  
Keyword(s):  
Network Structure ◽  
Positive Impact ◽  
Threshold Effect ◽  
Innovation Performance ◽  
Short Term ◽  
The Sustainable Development ◽  
Knowledge Based ◽  
D Investment ◽  
Positive Effect

The purpose of innovation is to consume fewer natural resources in order to create sustainable performance; therefore, innovation can ease the pressure of the ecological load and promote the sustainable development of the economy. Taking the 269 enterprises listed on the main board of the electronic information industry from 2010 to 2019 as samples, using the threshold panel data model, the nonlinear relationship between the knowledge-based network structure hole and the short-term and long-term innovation performance of the enterprises were studied, and the threshold effect of R&D investment intensity was discussed. When the R&D investment intensity is from 1.96% to 15.96%, the knowledge-based network structure hole has a significant positive impact on short-term innovation performance. When the R&D investment intensity is from 5.72% to 10.64%, the knowledge-based network structure hole has a significant positive effect on long-term innovation performance. Lower R&D investment intensity can make the knowledge-based network structure hole promote the increase of short term innovation performance, but to make the knowledge-based network structure hole have a positive impact on long term innovation performance, the R&D investment intensity should be increased by more than 5.72%. When R&D investment intensity is not higher than 15.96%, the knowledge-based network structure hole has a significant positive impact on short term innovation performance, but to make the knowledge-based network structure hole maintain the positive effect on long term innovation performance, R&D investment intensity should not exceed 10.64%. Therefore, enterprises should be guided to optimize the knowledge-based network structure according to the R&D investment intensity in order to improve the short term and long-term innovation performance of an enterprise. These research results can help enterprises to save resources and promote the sustainable development of the economy.

scholarly journals Assessment of the intellectual capital evaluation practices in Romanian IT companies

2019 ◽  
Vol 13 (1) ◽  
pp. 870-882
Author(s):  
Cynthia Bianka Incze ◽  
Simona Vasilache
Keyword(s):  
Intellectual Capital ◽  
Focal Point ◽  
Business Environment ◽  
Short Term ◽  
Evaluation Practices ◽  
Knowledge Based ◽  
Quantitative And Qualitative Research ◽  
Near Future ◽  
Evaluation Patterns

Abstract Intellectual capital started to raise and become a focal point of many businesses as they started invest in their own knowledge based activities and recognize its importance. In today’s world can be observed a more dynamic, flexible and growth oriented business environment than ever. Thus, the need for an increased amount of intangible assets in businesses lead to the recognition of the intellectual capital as a competitive advantage and strategic asset. Due to its expanding importance and relevance a significant number of measurement, valuation and evaluation methods were developed. Consensus regarding different methods was not yet reached, but all these methods are designed to help to get an approximation of the reality, thus contributing in short-term and long-term decision making. The aim of the paper is to assess the level of intellectual capital evaluation practices in multinational IT companies and IT SMEs in Romania. The study is questionnaire based and represents a mix of quantitative and qualitative research. Overall, although the challenge of intellectual capital evaluation remains significant, this study leads to the opportunity to identify evaluation patterns, best practices and a short list of useful evaluation indicators for businesses which already are or could be implemented in the near future.

The Future and Legal Education: Are Law Schools Failing and, If So, How?

2014 ◽  
Vol 39 (02) ◽  
pp. 499-521 ◽  
Author(s):  
Edward Rubin
Keyword(s):  
Degree Programs ◽  
Law Schools ◽  
Short Term ◽  
Knowledge Based ◽  
Knowledge Based Economy ◽  
Current Economic Crisis ◽  
Interdisciplinary Nature ◽  
Long Term Trends ◽  
Real Challenge

In Failing Law Schools (2010), Brian Tamanaha recommends that law schools respond to the current economic crisis in the legal profession by reducing support for faculty research and developing two‐year degree programs. But these ideas respond only to a short‐term problem that will probably be solved by the closure of marginal institutions. The real challenge lies in the powerful long‐term trends that animate social change, particularly the shift to a knowledge‐based economy and the demand for social justice through expanded public services. These trends demand that law schools transform their educational programs to reflect the regulatory, transactional, and interdisciplinary nature of modern legal practice.

scholarly journals Learning and memory

1989 ◽  
Vol 8 (1) ◽  
pp. 12-24
Author(s):  
P. A. J. Ryke
Keyword(s):  
Short Term Memory ◽  
Cultural Learning ◽  
Long Term Memory ◽  
Latent Learning ◽  
Short Term ◽  
Term Memory ◽  
The One ◽  
Definition Of

Under various circumstances and in different species the outward expression of learning varies considerably, and this has led to the classification of different categories of learning. Just as there is no generally agreed on definition of learning, there is no one system of classification. Types of learning commonly recognized are: Habituation, sensitization, classical conditioning, operant conditioning, trial and error, taste aversion, latent learning, cultural learning, imprinting, insight learning, learning-set learning and instinct. The term memory must include at least two separate processes. It must involve, on the one hand, that of learning something and on the other, at some later date, recalling that thing. What lies between the learning and (he remembering must be some permanent record — a memory trace — within the brain. Memory exists in at least two forms: memory for very recent events (short-term) which is relatively labile and easily disruptable; and long-term memory, which is much more stable. Not everything that gets into short-term memory becomes fixed in the long-term store; a filtering mechanism selects things that might be important and discards the rest.

BIOCHEMISTRY OF SHORT-TERM AND LONG-TERM MEMORY

2021 ◽  
Author(s):  
G. F. Stepanov ◽  
N. Y. Yasinenko ◽  
A. G. Vasylieva ◽  
V. L. Davydenko
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Short Term Memory ◽  
Long Term Memory ◽  
Synaptic Connections ◽  
Short Term ◽  
Local Synthesis ◽  
Term Memory ◽  
Kinase A

Memory is provided by changes in synapses in neural circuits: short-term memory - by functional changes in a separate sensory neuron and a separate motor neuron, long-term memory - by structural changes (regrowth of new synapses).During the formation of short-term memory in synapses, cAMP, protein kinase A, are used, which act inside the cell and transmit a signal that cause the release of large amounts of the neurotransmitter glutamate. Two independent mechanisms are involved in the formation of long-term memory: - one triggers a long-term strengthening of synaptic connections, directing protein kinase A to the nucleus, which activates the CREB protein, thereby turning on the structural genes encoding proteins necessary for the growth of new synaptic connections; - the other reinforces the already formed memory, supporting the newly formed synaptic endings, which requires local synthesis of proteins.

IMPLEMENTATION OF OPEN INNOVATION STRATEGIES: A BUYER–SUPPLIER PERSPECTIVE

2014 ◽  
Vol 18 (06) ◽  
pp. 1440013 ◽  
Author(s):  
DAVID T. ROSELL
Keyword(s):  
Open Innovation ◽  
Short Term ◽  
Knowledge Based ◽  
Trade Offs ◽  
Different Types ◽  
Multiple Case ◽  
Innovation Strategies ◽  
Opening Up

The open innovation concept has been discussed for more than a decade. However, there are relatively few studies related to implementation of open innovation. Barriers of implementation have been identified, but they are not related to the external knowledge searched for. This multiple-case study adds to current understanding of implementing open innovation strategies by focusing on the cooperation and coordination challenges when opening up for different types of supplier knowledge. Possible solutions and trade-offs between short-term benefits and long-term goals are presented that take into consideration the character of knowledge and human behavior. By applying theories such as knowledge-based view and transaction cost theories on empirical findings, different explanations are sought that bring new insights into managing open innovation.

A knowledge-based system for overall supply chain performance evaluation: a multi-criteria decision making approach

2019 ◽  
Vol 24 (3) ◽  
pp. 377-396 ◽  
Author(s):  
Sharfuddin Ahmed Khan ◽  
Amin Chaabane ◽  
Fikri Dweiri
Keyword(s):  
Supply Chain ◽  
Performance Evaluation ◽  
Decision Makers ◽  
Supply Chain Performance ◽  
Decision Criteria ◽  
Short Term ◽  
Content Type ◽  
Knowledge Based System ◽  
Knowledge Based

Purpose Existing supply chain (SC) performance models are not able to cope with the potential of intensive SC digitalisation and establish a relationship between decisions and decision criteria. The purpose of this paper is to develop an integrated knowledge-based system (KBS) that creates a link between decisions and decision criteria (attributes) and evaluates the overall SC performance. Design/methodology/approach The proposed KBS is grounded on the fuzzy analytic hierarchy process (fuzzy AHP), which establishes a relationship between short-term and long-term decisions and SC performance criteria (short-term and long-term) for accurate and integrated Overall SC performance evaluation. Findings The proposed KBS evaluates the overall SC performance, establishes a relationship between decisions (long-term and short-term) and decision criteria of SC functions and provides decision makers with a view of the impact of their short-term or long-term decisions on overall SC performance. The proposed system was implemented in a case company where the authors were able to develop a SC performance monitoring dashboard for the company’s top managers and operational managers. Practical implications The proposed KBS assists organisations and decision makers in evaluating their overall SC performance and helps in identifying underperforming SC functions and their associated criteria. It may also be considered as a tool for benchmarking SC performance against competitors. It can efficiently point to improvement directions and help decision makers improve overall SC performance. Originality/value The proposed KBS provides a holistic and integrated approach, establishes a relationship between decisions and decision criteria and evaluates overall SC performance, which is one of the main limitations in existing supply chain performance measurement systems.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

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