scholarly journals Image-based multi-scale modelling and validation of radio-frequency ablation in liver tumours

2011 ◽  
Vol 369 (1954) ◽  
pp. 4233-4254 ◽  
Author(s):  
Stephen Payne ◽  
Ronan Flanagan ◽  
Mika Pollari ◽  
Tuomas Alhonnoro ◽  
Claire Bost ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Radio Frequency ◽  
Radio Frequency Ablation ◽  
High Intensity Focused Ultrasound ◽  
Imaging Data ◽  
Clinical Implementation ◽  
Liver Tumours ◽  
Advantages And Disadvantages ◽  
Wide Range

The treatment of cancerous tumours in the liver remains clinically challenging, despite the wide range of treatment possibilities, including radio-frequency ablation (RFA), high-intensity focused ultrasound and resection, which are currently available. Each has its own advantages and disadvantages. For non- or minimally invasive modalities, such as RFA, considered here, it is difficult to monitor the treatment in vivo . This is particularly problematic in the liver, where large blood vessels act as heat sinks, dissipating delivered heat and shrinking the size of the lesion (the volume damaged by the heat treatment) locally; considerable experience is needed on the part of the clinician to optimize the heat treatment to prevent recurrence. In this paper, we outline our work towards developing a simulation tool kit that could be used both to optimize treatment protocols in advance and to train the less-experienced clinicians for RFA treatment of liver tumours. This tool is based on a comprehensive mathematical model of bio-heat transfer and cell death. We show how simulations of ablations in two pigs, based on individualized imaging data, compare directly with experimentally measured lesion sizes and discuss the likely sources of error and routes towards clinical implementation. This is the first time that such a ‘loop’ of mathematical modelling and experimental validation in vivo has been performed in this context, and such validation enables us to make quantitative estimates of error.

scholarly journals Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4199
Author(s):  
Mahshid Hafezi ◽  
Saied Nouri Khorasani ◽  
Mohadeseh Zare ◽  
Rasoul Esmaeely Neisiany ◽  
Pooya Davoodi
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Biomechanical Properties ◽  
Tissue Growth ◽  
Cartilage Tissue ◽  
Self Healing ◽  
Advantages And Disadvantages ◽  
Wide Range

Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tissue. The need to overcome the restrictions of these therapies for cartilage regeneration has expanded the field of cartilage tissue engineering (CTE), in which novel engineering and biological approaches are introduced to accelerate the development of new biomimetic cartilage to replace the injured tissue. Until now, a wide range of hydrogels and cell sources have been employed for CTE to either recapitulate microenvironmental cues during a new tissue growth or to compel the recovery of cartilaginous structures via manipulating biochemical and biomechanical properties of the original tissue. Towards modifying current cartilage treatments, advanced hydrogels have been designed and synthesized in recent years to improve network crosslinking and self-recovery of implanted scaffolds after damage in vivo. This review focused on the recent advances in CTE, especially self-healing hydrogels. The article firstly presents the cartilage tissue, its defects, and treatments. Subsequently, introduces CTE and summarizes the polymeric hydrogels and their advances. Furthermore, characterizations, the advantages, and disadvantages of advanced hydrogels such as multi-materials, IPNs, nanomaterials, and supramolecular are discussed. Afterward, the self-healing hydrogels in CTE, mechanisms, and the physical and chemical methods for the synthesis of such hydrogels for improving the reformation of CTE are introduced. The article then briefly describes the fabrication methods in CTE. Finally, this review presents a conclusion of prevalent challenges and future outlooks for self-healing hydrogels in CTE applications.

In vivo intracardiac OCT imaging through percutaneous access: towards image guided radio-frequency ablation

2012 ◽  
Author(s):  
Hui Wang ◽  
Wei Kang ◽  
Thomas Carrigan ◽  
Austin Bishop ◽  
Noah Rosenthal ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Radio Frequency Ablation ◽  
Percutaneous Access ◽  
Image Guided ◽  
Oct Imaging

Intracardiac myocardial elastography in humans in vivo during radio-frequency ablation

2013 ◽  
Vol 134 (5) ◽  
pp. 4214-4214
Author(s):  
Julien Grondin ◽  
Elaine Wan ◽  
Alok Gambhir ◽  
Stanley Okrasinski ◽  
Hasan Garan ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Radio Frequency Ablation

An ultrasound guided monitoring system for high intensity focused ultrasound and radio frequency ablation therapies

2016 ◽  
Vol 140 (4) ◽  
pp. 3309-3309
Author(s):  
Ryosuke Kondo ◽  
Norihiro Koizumi ◽  
Kyohei Tomita ◽  
Atsushi Kayasuga ◽  
Yu Nishiyama ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Monitoring System ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Radio Frequency Ablation ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Guided

scholarly journals In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources

ILAR Journal ◽  
2018 ◽  
Vol 59 (1) ◽  
pp. 80-98 ◽  
Author(s):  
Kathleen Gabrielson ◽  
Robert Maronpot ◽  
Sébastien Monette ◽  
Coraline Mlynarczyk ◽  
Yuval Ramot ◽  
...  
Keyword(s):  
Animal Model ◽  
In Vivo Imaging ◽  
Image Interpretation ◽  
Imaging Data ◽  
Case Examples ◽  
Animal Models Of Disease ◽  
Molecular Features ◽  
Wide Range ◽  
Models Of Disease

Abstract Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and microscopic morphological features, since all noninvasive in vivo imaging methods have much lower resolution than standard histopathology. Comprehensive pathological evaluation of the animal model is underutilized; yet, many institutions have veterinary or human pathologists with necessary comparative pathology expertise. By performing a rigorous comparison to gross or histopathology for image interpretation, these trained individuals can assist scientists with the development of the animal model, experimental design, and evaluation of the in vivo imaging data. These imaging and pathology corroboration studies undoubtedly increase scientific rigor and reproducibility in descriptive and hypothesis-driven research. A review of case examples including ultrasound, nuclear, optical, and MRI is provided to illustrate how a wide range of imaging modalities data can be confirmed by gross or microscopic pathology. This image confirmation and authentication will improve characterization of the model and may contribute to decreasing costs and number of animals used and to more rapid translation from preclinical animal model to the clinic.

scholarly journals MIN1PIPE: A Miniscope 1-photon-based Calcium Imaging Signal Extraction Pipeline

2018 ◽  
Author(s):  
Jinghao Lu ◽  
Chunyuan Li ◽  
Jonnathan Singh-Alvarado ◽  
Zhe Charles Zhou ◽  
Flavio Fröhlich ◽  
...  
Keyword(s):  
Calcium Imaging ◽  
Parameter Tuning ◽  
Superior Performance ◽  
Imaging Method ◽  
Imaging Data ◽  
Neural Signals ◽  
Neural Activities ◽  
Wide Range ◽  
Photon Imaging

SUMMARYIn vivo calcium imaging using 1-photon based miniscope and microendoscopic lens enables studies of neural activities in freely behaving animals. However, the high and fluctuating background, the inevitable movements and distortions of imaging field, and the extensive spatial overlaps of fluorescent signals emitted from imaged neurons inherent in this 1-photon imaging method present major challenges for extracting neuronal signals reliably and automatically from the raw imaging data. Here we develop a unifying algorithm called MINiscope 1-photon imaging PIPEline (MIN1PIPE) that contains several standalone modules and can handle a wide range of imaging conditions and qualities with minimal parameter tuning, and automatically and accurately isolate spatially localized neural signals. We quantitatively compare MIN1PIPE with other existing partial methods using both synthetic and real datasets obtained from different animal models, and show that MIN1PIPE has a superior performance both in terms of efficiency and precision in analyzing noisy miniscope calcium imaging data.

Evaluation of liver parenchymal pressure and portal endothelium damage during radio frequency ablation in an in vivo porcine model

2005 ◽  
Vol 25 (6) ◽  
pp. 1217-1223 ◽  
Author(s):  
Kazuhiro Kotoh ◽  
Shusuke Morizono ◽  
Motoyuki Kohjima ◽  
Munechika Enjoji ◽  
Hironori Sakai ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Porcine Model ◽  
Radio Frequency Ablation ◽  
Liver Parenchymal ◽  
Endothelium Damage
Sign in / Sign up

Export Citation Format

Share Document