Bioinspired supramolecular liquid crystals

Author(s):  
Virgil Percec

A brief account on the historical events leading to the discovery of self-assembling dendrons that generate self-organizable supramolecular dendrimers, or supramolecular polymers, and self-organizable dendronized polymers is provided. These building blocks were accessed by an accelerated design strategy that involves structural and retrostructural analysis of periodic and quasi-periodic assemblies. This design strategy mediated the discovery of porous helical supramolecular structures that self-assembled from dendritic dipeptides. Helical porous columns are the closest mimics of biologically related structures, such as tobacco mosaic virus coat, porous transmembrane proteins, porous pathogens and antibiotics. It is expected that this concept will allow one to investigate the structural origin of functions in synthetic supramolecular materials.

2014 ◽  
Vol 12 (33) ◽  
pp. 6292-6296 ◽  
Author(s):  
Rienk Eelkema ◽  
Jan H. van Esch

Catalytic formation of self-assembling building blocks provides control over the morphology, mechanical properties and spatial distribution of soft supramolecular materials.


Synlett ◽  
2020 ◽  
Vol 31 (05) ◽  
pp. 434-438 ◽  
Author(s):  
Maria C. Cringoli ◽  
Ottavia Bellotto ◽  
Rita De Zorzi ◽  
Attilio V. Vargiu ◽  
Silvia Marchesan

Minimalistic peptides composed of d- and l-amino acids are attractive building blocks for functional supramolecular materials, including catalysts. d-Amino acids have long been known to promote turn conformations in peptides, yet unexpected twists continue to emerge on their effects on self-assembly. The combination of single-crystal X-ray diffraction and full-atom molecular dynamics have finally unraveled fine details of how l-d-l-tripeptides visit different conformations in solution and establish key interactions in supramolecular structures.


2003 ◽  
Vol 773 ◽  
Author(s):  
C. Tamerler ◽  
S. Dinçer ◽  
D. Heidel ◽  
N. Karagûler ◽  
M. Sarikaya

AbstractProteins, one of the building blocks in organisms, not only control the assembly in biological systems but also provide most of their complex functions. It may be possible to assemble materials for practical technological applications utilizing the unique advantages provided by proteins. Here we discuss molecular biomimetic pathways in the quest for imitating biology at the molecular scale via protein engineering. We use combinatorial biology protocols to select short polypeptides that have affinity to inorganic materials and use them in assembling novel hybrid materials. We give an overview of some of the recent developments of molecular engineering towards this goal. Inorganic surface specific proteins were identified by using cell surface and phage display technologies. Examples of metal and metal oxide specific polypeptides were represented with an emphasis on certain level of specificities. The recognition and self assembling characteristics of these inorganic-binding proteins would be employed in develeopment of hybrid multifunctional materials for novel bio- and nano-technological applications.


2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.


Crystals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 678
Author(s):  
Yuqi Han ◽  
Yan Jiang ◽  
Wei Guo ◽  
Bing Li ◽  
Lu Zhang ◽  
...  

Based on the anchoring effect due to the self-assembling behavior of the phospholipid molecules at the interface between the liquid crystal and water phases on the orientation of liquid crystals, the optical response associated with the orientation and structure of liquid crystals with respect to the concentration of 1,2-didodecanoyl-sn-glycero-3-phosphocholine solution has been investigated. The optical response owing to changes in the orientation and structure of the mixed cholesteric liquid crystals with respect to the change in the concentration of phosphatidylcholine has been obtained. Moreover, the feasibility of using as-prepared mixed cholesteric liquid crystals to measure the phosphatidylcholine concentration has been verified. A methodology to measure the reflectance spectrum by using mixed cholesteric liquid crystals to sensitize the phosphatidylcholine concentration has been further realized. The sensitization effect of the mixed cholesteric liquid crystals on the measurement of phosphatidylcholine concentration was also verified.


1995 ◽  
Vol 98 (1) ◽  
pp. 483-490
Author(s):  
J. L. M. van Nunen ◽  
A. P. H. J. Schenning ◽  
R. J. H. Hafkamp ◽  
C. F. van Nostrum ◽  
M. C. Feiters ◽  
...  

2021 ◽  
Author(s):  
Thomas Ohnemus ◽  
Hannes Mollenhauer ◽  
Michael Mirtl ◽  
Steffen Zacharias

<p>The integrated European Long-Term Ecosystem, critical zone and socio-ecological Research Infrastructure (eLTER RI) was accepted onto the ESFRI roadmap in 2018. While several existing thematic environmental RIs in Europe focus on impacts of climate change and/or other elements of environmental change, eLTER RI will be the only research infrastructure embracing holistically the integrated impacts of such stressors on a wide variety of European benchmark ecosystems (major geo-eco-sociological systems across the continent’s ecoclimatological zones and Earth’s critical zone). In the beginning of 2020 eLTER RI entered the preparatory phase aiming at the development of the legal, financial and technical maturity required for an ESFRI Research Infrastructure.</p><p>The core of the eLTER RI will be ca. 200 selected sites covering all biogeographical zones in Europe, where biological, biogeochemical, hydrological and socio-ecological data will be collected - according to common standards - and analyzed. The European landscape of LTER sites and national networks has mainly been developed in a bottom-up manner. The sites have mostly been established for different monitoring and research purposes and are heterogeneous in terms of investigated ecosystem types, scales of investigation, complexity and instrumentation. Consequently, the transformation of the selected elements of the eLTER RI into a harmonized, high-performance, complementary and interoperable infrastructure is one of the key challenges of eLTER. Achieving the best possible representativity is on the major building blocks in eLTER’s design strategy.</p><p>To evaluate the representativity of eLTER a novel statistical approach combining information on biogeographical, ecological and socio-economic gradients with the management-relevant distribution of established sites was developed aiming at  i) identification of areas in Europe that are geographically underrepresented by the existing eLTER RI site network, ii) definition of priority regions for the geographical extension of the eLTER site network and, iii) development of suggestions for conceptual and infrastructural upgrades for existing less developed eLTER sites.</p><p>Reference datasets depicting biogeographical, ecological and socio-economical gradients were used to describe underrepresentation with a summation parameter called Aggregated Representedness. This statistical criterion was then used to classify five types of “priority regions” from very low to very high priority for geographical and/or conceptual extension. In a second step this information on priority regions was refined using additional information describing the geographical distribution based on Euclidean distances between established eLTER sites.  The combination of these two analyses allowed to identify less developed eLTER sites most suitable for conceptual and infrastructural upgrades. Thus, the presented analysis provides important information for the development of the design strategy for eLTER RI on the continental scale.</p><p>Concluding, a novel approach combining information on biogeographical, ecological and socio-economic gradients with the management-relevant information on the geographical distribution of established sites was developed. This tool allows to evaluate the strategies for further extension of established site networks. </p>


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