Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerability

2006 ◽  
Vol 364 (1843) ◽  
pp. 1333-1348 ◽  
Author(s):  
David W Bourn ◽  
Mary M Maleckar ◽  
Blanca Rodriguez ◽  
Natalia A Trayanova
Keyword(s):  
Cycle Length ◽  
Three Dimensional ◽  
Element Model ◽  
Shock Strength ◽  
Upper Limit ◽  
Upper Limit Of Vulnerability ◽  
Post Shock ◽  
Unidirectional Block ◽  
Isoelectric Window ◽  
Basic Cycle Length

The goal of this study is to investigate the mechanisms responsible for the increase in the upper limit of vulnerability (ULV; highest shock strength that induces arrhythmia) following the increase in pacing rate. To accomplish this goal, the study employs a three-dimensional bidomain finite element model of a slice through the canine ventricles. The preparation was paced eight times at a basic cycle length (BCL) of either 80 or 150 ms followed by delivery of shocks of various strengths and timings. Our results demonstrate that the shock strength, which induced an arrhythmia 50% of the time, increased 20% for the faster pacing compared to the slower pacing. Analysis of the mechanisms underlying the increased vulnerability revealed that delayed post-shock activations originating in the tissue depths appear as breakthrough activations on the surfaces of the preparation following an isoelectric window (IW). However, the IW duration was consistently shorter in the faster-paced preparation. Consequently, breakthrough activations appeared on the surfaces of this preparation earlier, when the tissue was less recovered, resulting in higher probability of unidirectional block and reentry. This explains why shocks of the same strength were more likely to result in arrhythmia induction when delivered to a preparation that was rapidly paced.

Effect of acute global ischemia on the upper limit of vulnerability: a simulation study

2004 ◽  
Vol 286 (6) ◽  
pp. H2078-H2088 ◽  
Author(s):  
Blanca Rodríguez ◽  
Brock M. Tice ◽  
James C. Eason ◽  
Felipe Aguel ◽  
José M. Ferrero ◽  
...  
Keyword(s):  
Membrane Dynamics ◽  
Global Ischemia ◽  
Acute Ischemia ◽  
Shock Strength ◽  
Upper Limit ◽  
Upper Limit Of Vulnerability ◽  
Electric Shocks ◽  
Reentrant Arrhythmia ◽  
Stage 1 ◽  
Two Stages

The goal of this modeling research is to provide mechanistic insight into the effect of altered membrane kinetics associated with 5–12 min of acute global ischemia on the upper limit of cardiac vulnerability (ULV) to electric shocks. We simulate electrical activity in a finite-element bidomain model of a 4-mm-thick slice through the canine ventricles that incorporates realistic geometry and fiber architecture. Global acute ischemia is represented by changes in membrane dynamics due to hyperkalemia, acidosis, and hypoxia. Two stages of acute ischemia are simulated corresponding to 5–7 min ( stage 1) and 10–12 min ( stage 2) after the onset of ischemia. Monophasic shocks are delivered in normoxia and ischemia over a range of coupling intervals, and their outcomes are examined to determine the highest shock strength that resulted in induction of reentrant arrhythmia. Our results demonstrate that acute ischemia stage 1 results in ULV reduction to 0.8A from its normoxic value of 1.4A. In contrast, no arrhythmia is induced regardless of shock strength in acute ischemia stage 2. An investigation of mechanisms underlying this behavior revealed that decreased postshock refractoriness resulting mainly from 1) ischemic electrophysiological substrate and 2) decrease in the extent of areas positively-polarized by the shock is responsible for the change in ULV during stage 1. In contrast, conduction failure is the main cause for the lack of vulnerability in acute ischemia stage 2. The insight provided by this study furthers our understanding of mechanisms by which acute ischemia-induced changes at the ionic level modulate cardiac vulnerability to electric shocks.

Torsional Analysis of a Steel Cord-Rubber Tire Belt Structure

1996 ◽  
Vol 24 (4) ◽  
pp. 339-348 ◽  
Author(s):  
R. M. V. Pidaparti
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Composite Structures ◽  
Three Dimensional ◽  
Element Model ◽  
Torsional Stiffness ◽  
Element Analysis ◽  
Rubber Belt ◽  
Steel Cord ◽  
Torsional Analysis

Abstract A three-dimensional (3D) beam finite element model was developed to investigate the torsional stiffness of a twisted steel-reinforced cord-rubber belt structure. The present 3D beam element takes into account the coupled extension, bending, and twisting deformations characteristic of the complex behavior of cord-rubber composite structures. The extension-twisting coupling due to the twisted nature of the cords was also considered in the finite element model. The results of torsional stiffness obtained from the finite element analysis for twisted cords and the two-ply steel cord-rubber belt structure are compared to the experimental data and other alternate solutions available in the literature. The effects of cord orientation, anisotropy, and rubber core surrounding the twisted cords on the torsional stiffness properties are presented and discussed.

Finite Element Analysis of Nonuniformity of Tires with Imperfections5

2007 ◽  
Vol 35 (3) ◽  
pp. 226-238 ◽  
Author(s):  
K. M. Jeong ◽  
K. W. Kim ◽  
H. G. Beom ◽  
J. U. Park
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Three Dimensional ◽  
Element Model ◽  
Radial Force ◽  
Element Analysis ◽  
The Finite Element Analysis ◽  
Dimensional Finite Element ◽  
Force Variation ◽  
Three Dimensional Finite Element

Abstract The effects of variations in stiffness and geometry on the nonuniformity of tires are investigated by using the finite element analysis. In order to evaluate tire uniformity, a three-dimensional finite element model of the tire with imperfections is developed. This paper considers how imperfections, such as variations in stiffness or geometry and run-out, contribute to detrimental effects on tire nonuniformity. It is found that the radial force variation of a tire with imperfections depends strongly on the geometrical variations of the tire.

scholarly journals Comparison of Tooth- and Bone-Borne Appliances on the Stress Distributions and Displacement Patterns in the Facial Skeleton in Surgically Assisted Rapid Maxillary Expansion—A Finite Element Analysis (FEA) Study

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1152
Author(s):  
Rafał Nowak ◽  
Anna Olejnik ◽  
Hanna Gerber ◽  
Roman Frątczak ◽  
Ewa Zawiślak
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Three Dimensional ◽  
Element Model ◽  
Rapid Maxillary Expansion ◽  
Stress Distributions ◽  
Maxillary Expansion ◽  
Facial Skeleton ◽  
Element Analysis ◽  
Maxillary Constriction

The aim of this study was to compare the reduced stresses according to Huber’s hypothesis and the displacement pattern in the region of the facial skeleton using a tooth- or bone-borne appliance in surgically assisted rapid maxillary expansion (SARME). In the current literature, the lack of updated reports about biomechanical effects in bone-borne appliances used in SARME is noticeable. Finite element analysis (FEA) was used for this study. Six facial skeleton models were created, five with various variants of osteotomy and one without osteotomy. Two different appliances for maxillary expansion were used for each model. The three-dimensional (3D) model of the facial skeleton was created on the basis of spiral computed tomography (CT) scans of a 32-year-old patient with maxillary constriction. The finite element model was built using ANSYS 15.0 software, in which the computations were carried out. Stress distributions and displacement values along the 3D axes were found for each osteotomy variant with the expansion of the tooth- and the bone-borne devices at a level of 0.5 mm. The investigation showed that in the case of a full osteotomy of the maxilla, as described by Bell and Epker in 1976, the method of fixing the appliance for maxillary expansion had no impact on the distribution of the reduced stresses according to Huber’s hypothesis in the facial skeleton. In the case of the bone-borne appliance, the load on the teeth, which may lead to periodontal and orthodontic complications, was eliminated. In the case of a full osteotomy of the maxilla, displacements in the buccolingual direction for all the variables of the bone-borne appliance were slightly bigger than for the tooth-borne appliance.

scholarly journals Vibration characteristics of triple-gear-rotor system in compressed air energy storage under variable torque load

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042098705
Author(s):  
Xinran Wang ◽  
Yangli Zhu ◽  
Wen Li ◽  
Dongxu Hu ◽  
Xuehui Zhang ◽  
...  
Keyword(s):  
Large Scale ◽  
Three Dimensional ◽  
Element Model ◽  
Rotor System ◽  
Dynamic Responses ◽  
System Response ◽  
Rotating Speed ◽  
Torque Load ◽  
Set Up ◽  
Two Stages

This paper focuses on the effects of the off-design operation of CAES on the dynamic characteristics of the triple-gear-rotor system. A finite element model of the system is set up with unbalanced excitations, torque load excitations, and backlash which lead to variations of tooth contact status. An experiment is carried out to verify the accuracy of the mathematical model. The results show that when the system is subjected to large-scale torque load lifting at a high rotating speed, it has two stages of relatively strong periodicity when the torque load is light, and of chaotic when the torque load is heavy, with the transition between the two states being relatively quick and violent. The analysis of the three-dimensional acceleration spectrum and the meshing force shows that the variation in the meshing state and the fluctuation of the meshing force is the basic reasons for the variation in the system response with the torque load. In addition, the three rotors in the triple-gear-rotor system studied show a strong similarity in the meshing states and meshing force fluctuations, which result in the similarity in the dynamic responses of the three rotors.

scholarly journals Internal Force on and Deformation of Steel Assembled Supporting Structure of Foundation Pit under Thermal Stress

2021 ◽  
Vol 11 (5) ◽  
pp. 2225
Author(s):  
Fu Wang ◽  
Guijun Shi ◽  
Wenbo Zhai ◽  
Bin Li ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Bending Moment ◽  
High Strength ◽  
Element Model ◽  
Internal Force ◽  
Foundation Pit ◽  
Dimensional Finite Element ◽  
Influence Of Temperature On ◽  
Scale Experiment ◽  
Three Dimensional Finite Element

The steel assembled support structure of a foundation pit can be assembled easily with high strength and recycling value. Steel’s performance is significantly affected by the surrounding temperature due to its temperature sensitivity. Here, a full-scale experiment was conducted to study the influence of temperature on the internal force and deformation of supporting structures, and a three-dimensional finite element model was established for comparative analysis. The test results showed that under the temperature effect, the deformation of the central retaining pile was composed of rigid rotation and flexural deformation, while the adjacent pile of central retaining pile only experienced flexural deformation. The stress on the retaining pile crown changed little, while more stress accumulated at the bottom. Compared with the crown beam and waist beam 2, the stress on waist beam 1 was significantly affected by the temperature and increased by about 0.70 MPa/°C. Meanwhile, the stress of the rigid panel was greatly affected by the temperature, increasing 78% and 82% when the temperature increased by 15 °C on rigid panel 1 and rigid panel 2, respectively. The comparative simulation results indicated that the bending moment and shear strength of pile 1 were markedly affected by the temperature, but pile 2 and pile 3 were basically stable. Lastly, as the temperature varied, waist beam 2 had the largest change in the deflection, followed by waist beam 1; the crown beam experienced the smallest change in the deflection.

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