scholarly journals Trans-generational effects of prenatal stress in quail

2013 ◽  
Vol 280 (1753) ◽  
pp. 20122368 ◽  
Author(s):  
Floriane Guibert ◽  
Sophie Lumineau ◽  
Kurt Kotrschal ◽  
Erich Möstl ◽  
Marie-Annick Richard-Yris ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Phenotypic Variability ◽  
Reproductive Traits ◽  
Long Term Effects ◽  
Stress Effects ◽  
Generational Transmission ◽  
Generational Effects ◽  
Prenatally Stressed ◽  
Yolk Testosterone

The prenatal environment is a source of phenotypic variability influencing the animal's characteristics. Prenatal stress affects not only the development of offspring, but also that of the following generation. Such effects have been best documented in mammals but can also be observed in birds, suggesting common processes across phylogenetic orders. We found previously that Japanese quail females stressed during laying produced offspring with higher fearfulness, probably related to modulation of testosterone levels in their eggs. Here, we evaluated long-term effects of prenatal stress by analysing reproductive traits of these F 1 offspring and, then, the development of their subsequent (F 2 ) offspring. The sexual behaviour of F 1 prenatally stressed (F1PS) males was impaired. F1PS females' eggs contained less yolk and more albumen, and higher yolk testosterone and progesterone levels than did F 1 prenatal control females. The fearfulness of F 2 prenatally stressed quail was greater than that of F 2 prenatal control quail. These F 2 behavioural differences paralleled those evidenced by their parents, suggesting trans-generational transmission of prenatal stress effects, probably mediated by egg compositions of F1PS females.

New Insights into Prenatal Stress: Immediate- and Long-Term Effects on the Fetus and Their Timing

Neonatal Pain ◽  
2017 ◽  
pp. 75-85
Author(s):  
Kieran J. O’Donnell ◽  
Nadja Reissland ◽  
Vivette Glover
Keyword(s):  
Prenatal Stress ◽  
Long Term Effects

Long term effects of high fat diet given early in life in prenatally stressed rats: role of the inflammatory response

2019 ◽  
Vol 29 ◽  
pp. S225-S226
Author(s):  
M. Mazzelli ◽  
N. Cattane ◽  
C. Mora ◽  
V. Begni ◽  
A. Berry ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
High Fat Diet ◽  
Long Term Effects ◽  
High Fat ◽  
Prenatally Stressed

Long-term effects of prenatal stress and handling on metabolic parameters: relationship to corticosterone secretion response

1996 ◽  
Vol 712 (2) ◽  
pp. 287-292 ◽  
Author(s):  
Monique Vallée ◽  
Willy Mayo ◽  
Stefania Maccari ◽  
Michel Le Moal ◽  
Hervé Simon
Keyword(s):  
Prenatal Stress ◽  
Metabolic Parameters ◽  
Long Term Effects ◽  
Corticosterone Secretion

Effects of prenatal restraint stress on hypothalamic-pituitary-adrenocortical and sympatho-adrenomedullary axis in neonatal pigs

2001 ◽  
Vol 73 (2) ◽  
pp. 279-287 ◽  
Author(s):  
W. Often ◽  
E. Kanitz ◽  
M. Tuchscherer ◽  
G. Nürnberg
Keyword(s):  
Prenatal Stress ◽  
Restraint Stress ◽  
Challenge Test ◽  
Late Gestation ◽  
Neonatal Pigs ◽  
Stress Effects ◽  
Free Cortisol ◽  
Corticosteroid Binding Globulin ◽  
Basal Plasma ◽  
Prenatally Stressed

AbstractStudies in rodents and primates strongly indicate that prenatal stress affects the survival, behaviour and physiology of the offspring. Stressful stimuli during gestation may have a direct or hormone mediated effect on the development of stress systems in the foetal organism, resulting in an altered coping during stressful situations. The present study was conducted to elucidate prenatal stress effects in domestic pigs on the responses of the hypothalamicpituitary- adrenocortical (HPA) axis and the sympatho-adrenomedullary (SAM) system as well as on morbidity, mortality and growth of the offspring. Pregnant sows were subjected to a restraint stress for five minutes daily during the last five weeks of gestation. Endocrine reactions of the piglets were tested at 3, 7, 21 and 35 days of age using an immobilization test and an ACTH challenge test. Prenatally stressed piglets showed lower basal plasma cortisol and increased corticosteroid binding globulin (CBG) concentrations at 3 days of age, indicating decreased free cortisol concentrations after birth. Cortisol levels after ACTH stimulation and catecholamine levels after immobilization were not affected by the stress treatment of the sows. Piglets from stressed sows tended to have lower noradrenaline : adrenaline ratios at three days of age compared with the control piglets. In addition, stressed sows tended to have lower litter weights after birth. The morbidity and mortality during the suckling period was higher in the prenatally stressed litters, as shown by a higher frequency of diseased and perished piglets per litter. We suppose that prenatal stress during late gestation in pigs alters the development of the HPA system and impairs the vitality of the offspring.

scholarly journals Early and long-term neuroendocrine effects of prenatal stress in male and female rats

2000 ◽  
Vol 46 (1) ◽  
pp. 30-34 ◽  
Author(s):  
A. G. Reznikov ◽  
N. D. Nosenko ◽  
L. V. Tarasenko ◽  
P. V. Sinitsyn ◽  
L. I. Polyakova
Keyword(s):  
Prenatal Stress ◽  
Stress Reactivity ◽  
Female Rats ◽  
Male And Female Rats ◽  
Prenatally Stressed ◽  
Old Rats ◽  
Males And Females ◽  
Morphological Equivalent ◽  
The Brain

The effect of maternal stress or so-called prenatal stress (PS) on the neuroendocrine regulation of reproduction and stress reactivity of the progeny was studied. Prenatal stress prevented the formation of sex dimorphism of catecholamine content and aromatase and androgen 5a-reductase activities in the preoptic region of the brain and mediobasal hypothalamus of 10-day-old rats. Leveling of sex-specific differences in the size of the neurocyte nuclei in the suprachiasmatic nucleus was the morphological equivalent of functional disorders induced by PS. Stress and adrenergic reactivity of the hypothalamo-pituitary-adrenal system was changed in prenatally stressed males and females. Remote effects of PS are regarded as a manifestation of disorders in the hormone neurotransmitter imprinting of the neuroendocrine system.

scholarly journals Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27549 ◽  
Author(s):  
Eva Baquedano ◽  
Cristina García-Cáceres ◽  
Yolanda Diz-Chaves ◽  
Natalia Lagunas ◽  
Isabel Calmarza-Font ◽  
...  
Keyword(s):  
Adult Male ◽  
Prenatal Stress ◽  
Male Rats ◽  
Cell Turnover ◽  
Long Term Effects

scholarly journals The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures

2017 ◽  
Vol 11 ◽  
pp. 117906951770466 ◽  
Author(s):  
Nombuso Valencia Pearl Mkhize ◽  
Lihle Qulu ◽  
Musa Vuyisile Mabandla
Keyword(s):  
Rat Model ◽  
Prenatal Stress ◽  
Inflammatory Marker ◽  
Interleukin 1 ◽  
Febrile Seizures ◽  
Sprague Dawley ◽  
Stress Effects ◽  
Rat Pups ◽  
Prenatally Stressed ◽  
Anti Inflammatory

Febrile seizures are childhood convulsions resulting from an infection that leads to an inflammatory response and subsequent convulsions. Prenatal stress has been shown to heighten the progression and intensity of febrile seizures. Current medications are costly and have adverse effects associated with prolonged use. Quercetin flavonoid exhibits anti-inflammatory, anti-convulsant, and anti-stress effects. This study was aimed to investigate the therapeutic effect of quercetin in a prenatally stressed rat model of febrile seizures. We hypothesized that quercetin will alleviate the effects of prenatal stress in a febrile seizure rat model. On gestational day 13, Sprague-Dawley rat dams were subjected to restraint stress for 1 hour/d for 7 days. Febrile seizures were induced on postnatal day 14 on rat pups by intraperitoneally injecting lipopolysaccharide followed by kainic acid and quercetin on seizure onset. Hippocampal tissue was harvested to profile cytokine concentrations. Our results show that quercetin suppresses prenatal stress–induced pro-inflammatory marker (interleukin 1 beta) levels, subsequently attenuating febrile seizures. This shows that quercetin can be therapeutic for febrile seizures in prenatally stressed individuals.

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