scholarly journals Social and extra-pair mating in relation to major histocompatibility complex variation in common yellowthroats

2012 ◽  
Vol 279 (1748) ◽  
pp. 4778-4785 ◽  
Author(s):  
Jennifer L. Bollmer ◽  
Peter O. Dunn ◽  
Corey R. Freeman-Gallant ◽  
Linda A. Whittingham
Keyword(s):  
Major Histocompatibility Complex ◽  
Critical Role ◽  
Female Mate Choice ◽  
Major Histocompatibility ◽  
Male Health ◽  
Histocompatibility Complex ◽  
Pair Mating ◽  
Mhc Diversity ◽  
Complex Variation ◽  
Extra Pair Mating

Females are thought to gain better-quality genes for their offspring by mating with particular males. Genes of the major histocompatibility complex (MHC) play a critical role in adaptive immunity, and several studies have examined female mate choice in relation to MHC variation. In common yellowthroats, females prefer males that have larger black facial masks, an ornament associated with MHC variation, immune function and condition. Here we also tested whether mating patterns are directly correlated with MHC diversity or similarity. Using pyrosequencing, we found that the presence of extra-pair young in the brood was not related to male MHC diversity or similarity between the female and her within-pair mate. Furthermore, extra-pair sires did not differ in overall diversity from males they cuckolded, or in their similarity to the female. MHC diversity is extremely high in this species, and it may limit the ability of females to assess MHC variation in males. Thus, mating may be based on ornaments, such as mask size, which are better indicators of overall male health and genetic quality.

scholarly journals Mate choice for major histocompatibility complex (MHC) complementarity in the Yellow-rumped Flycatcher (Ficedula zanthopygia)

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mingju E ◽  
Xiaolei Song ◽  
Liufang Wang ◽  
Yimo Yang ◽  
Xianxiu Wei ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Mate Choice ◽  
Female Mate Choice ◽  
Social Monogamy ◽  
Major Histocompatibility ◽  
Female Mate ◽  
Histocompatibility Complex ◽  
Animal Populations ◽  
Mhc Diversity ◽  
Mhc Iib

Abstract Background Genes of the major histocompatibility complex (MHC) are an important component of the vertebrate immune system and play a significant role in mate choice in animal populations. However, the MHC genetic targets of female mate choice have not been clearly identified, and whether female mate choice is based on neutral genetic characteristics remains an open question. Here, we focus on the effects of morphological traits and genetic similarity among individuals in MHC class IIB (MHC IIB) exon 2 on mating in a sexually dimorphic songbird that exhibits social monogamy with extra-pair paternity (EPP). Methods We sequenced 64 parent–offspring triads sampled over a 3-year period using two MHC class II loci to detect disassortative mating in the Yellow-rumped Flycatcher (Ficedula zanthopygia). Results We found that MHC similarity in social pairs was lower than that in random pairs. Extra-pair mate choice according to MHC IIB was observed, in which females’ extra-pair mates had fewer MHC alleles than their within-pair mates, but there was no significant band-sharing between extra-pair sires and potential extra-pair mates. However, the interaction between the MHC diversity of females and that of the social males affected the occurrence of EPP. Conclusions Our results support the “optimality hypothesis” of MHC-based social and extra-pair choice. Female choice probably maintains a certain level of MHC diversity in offspring in the Yellow-rumped Flycatcher.

scholarly journals Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemics

2013 ◽  
Vol 9 (1) ◽  
pp. 20120900 ◽  
Author(s):  
Katrina Morris ◽  
Jeremy J. Austin ◽  
Katherine Belov
Keyword(s):  
Major Histocompatibility Complex ◽  
Tasmanian Devil ◽  
Major Histocompatibility ◽  
European Settlement ◽  
Low Genetic Diversity ◽  
Histocompatibility Complex ◽  
Devil Facial Tumour Disease ◽  
History Of ◽  
Mhc Diversity ◽  
Disease Epidemics

The Tasmanian devil ( Sarcophilus harrisii ) is at risk of extinction owing to the emergence of a contagious cancer known as devil facial tumour disease (DFTD). The emergence and spread of DFTD has been linked to low genetic diversity in the major histocompatibility complex (MHC). We examined MHC diversity in historical and ancient devils to determine whether loss of diversity is recent or predates European settlement in Australia. Our results reveal no additional diversity in historical Tasmanian samples. Mainland devils had common modern variants plus six new variants that are highly similar to existing alleles. We conclude that low MHC diversity has been a feature of devil populations since at least the Mid-Holocene and could explain their tumultuous history of population crashes.

scholarly journals Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 ◽  
Vol 177 (6) ◽  
pp. 1699-1712 ◽  
Author(s):  
E K Bikoff ◽  
L Y Huang ◽  
V Episkopou ◽  
J van Meerwijk ◽  
R N Germain ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Mhc Class Ii ◽  
Critical Role ◽  
Class Ii ◽  
Intact Protein ◽  
Invariant Chain ◽  
Major Histocompatibility ◽  
Protein Antigens ◽  
Histocompatibility Complex ◽  
Class Ii Alpha

We used gene targeting techniques to produce mice lacking the invariant chain associated with major histocompatibility complex (MHC) class II molecules. Cells from these mice show a dramatic reduction in surface class II, resulting from both defective association of class II alpha and beta chains and markedly decreased post-Golgi transport. The few class II alpha/beta heterodimers reaching the cell surface behave as if empty or occupied by an easily displaced peptide, and display a distinct structure. Mutant spleen cells are defective in their ability to present intact protein antigens, but stimulate enhanced responses in the presence of peptides. These mutant mice have greatly reduced numbers of thymic and peripheral CD4+ T cells. Overall, this striking phenotype establishes that the invariant chain plays a critical role in regulating MHC class II expression and function in the intact animal.

Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants

2010 ◽  
Vol 62 (2) ◽  
pp. 85-100 ◽  
Author(s):  
Elizabeth A. Archie ◽  
Tammy Henry ◽  
Jesus E. Maldonado ◽  
Cynthia J. Moss ◽  
Joyce H. Poole ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation

scholarly journals Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.

1992 ◽  
Vol 175 (1) ◽  
pp. 305-308 ◽  
Author(s):  
G Benichou ◽  
P A Takizawa ◽  
C A Olson ◽  
M McMillan ◽  
E E Sercarz
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Critical Role ◽  
Major Histocompatibility ◽  
Skin Allograft ◽  
Mhc Molecules ◽  
Histocompatibility Complex ◽  
Molecular Therapies ◽  
Antigen Presenting

Peptides from donor major histocompatibility complex (MHC) molecules were examined for their activation of allogeneically primed T cells. After immunization with either allogeneic spleen cells or a skin allograft, primed T cells proliferate in response to peptides derived from polymorphic regions of alpha and beta chains of class II allo-MHC molecules. The results demonstrate that presentation of donor-MHC peptides by host-derived antigen-presenting cells is a common event in vivo. Thus, self-restricted T cell recognition of processed alloantigens may play a critical role in transplantation. An in-depth understanding of this response may result in the development of additional molecular therapies to combat allograft rejection.

Stock Identification of Fraser River Sockeye Salmon Using Microsatellites and Major Histocompatibility Complex Variation

2004 ◽  
Vol 133 (5) ◽  
pp. 1117-1137 ◽  
Author(s):  
Terry D. Beacham ◽  
Michael Lapointe ◽  
John R. Candy ◽  
Brenda McIntosh ◽  
Cathy MacConnachie ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Sockeye Salmon ◽  
Stock Identification ◽  
Fraser River ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Complex Variation
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