scholarly journals Egg size-dependent expression of growth hormone receptor accompanies compensatory growth in fish

2011 ◽  
Vol 279 (1728) ◽  
pp. 592-600 ◽  
Author(s):  
F. H. I. D. Segers ◽  
G. Berishvili ◽  
B. Taborsky
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Egg Size ◽  
Growth Hormone Receptor ◽  
Yolk Sac ◽  
Juvenile Growth ◽  
Somatotropic Axis ◽  
Expression Levels ◽  
Potential Link ◽  
Adaptive Adjustment

Large egg size usually boosts offspring survival, but mothers have to trade off egg size against egg number. Therefore, females often produce smaller eggs when environmental conditions for offspring are favourable, which is subsequently compensated for by accelerated juvenile growth. How this rapid growth is modulated on a molecular level is still unclear. As the somatotropic axis is a key regulator of early growth in vertebrates, we investigated the effect of egg size on three key genes belonging to this axis, at different ontogenetic stages in a mouthbrooding cichlid ( Simochromis pleurospilus ). The expression levels of one of them, the growth hormone receptor ( GHR ), were significantly higher in large than in small eggs, but remarkably, this pattern was reversed after hatching: young originating from small eggs had significantly higher GHR expression levels as yolk sac larvae and as juveniles. GHR expression in yolk sac larvae was positively correlated with juvenile growth rate and correspondingly fish originating from small eggs grew faster. This enabled them to catch up fully in size within eight weeks with conspecifics from larger eggs. This is the first evidence for a potential link between egg size, an important maternal effect, and offspring gene expression, which mediates an adaptive adjustment in a relevant hormonal axis.

scholarly journals Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants

2019 ◽  
Vol 123 (6) ◽  
pp. 652-663 ◽  
Author(s):  
Caroline S. Firmenich ◽  
Nadine Schnepel ◽  
Kathrin Hansen ◽  
Marion Schmicke ◽  
Alexandra S. Muscher-Banse
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Growth Hormone Receptor ◽  
Control Diet ◽  
Insulin Like Growth Factor ◽  
Somatotropic Axis ◽  
Blood Concentrations ◽  
Expression Levels ◽  
Protein Reduction ◽  
The Impact

AbstractA reduced protein intake causes a decrease in insulin-like growth factor 1 (IGF1) concentrations and modulates Ca homoeostasis in young goats. IGF1 is synthesised by the liver in response to stimulation by growth hormone (GH). Due to rumino-hepatic circulation of urea, ruminants are suitable for investigating the effects of protein reduction despite sufficient energy intake. The present study aimed to investigate the impact of a protein-reduced diet on the expression of components of the somatotropic axis. Male young goats were divided into two feeding groups receiving either a control diet (20 % crude protein (CP)) or a reduced-protein diet (9 % CP). Blood concentrations of IGF1 and GH were measured, and a 24-h GH secretion profile was compiled. Moreover, ionised Ca and insulin concentrations as well as mRNA and protein expression levels of hepatic proteins involved in GH signalling were quantified. Due to the protein-reduced diet, concentrations of ionised Ca, insulin and IGF1 decreased significantly, whereas GH concentrations remained unchanged. Expression levels of the hepatic GH receptor (GHR) decreased during protein reduction. GHR expression was down-regulated due to diminished insulin concentrations as both parameters were positively correlated. Insulin itself might be reduced due to reduced blood Ca levels that are involved in insulin release. The protein-reduced diet had an impact on the expression of components of the somatotropic axis as a disruption of the GH–IGF1 axis brought about by diminished GHR expression was shown in response to a protein-reduced diet.

Laron syndrome – A case Report

JMS SKIMS ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 104-106
Author(s):  
Javaid Ahmad Bhat ◽  
Moomin Hussain Bhat ◽  
Hilal Bhat ◽  
Mona Sood ◽  
Shariq Rashid Masoodi
Keyword(s):  
Growth Hormone ◽  
Case Report ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Genetic Disorder ◽  
Female Child ◽  
Receptor Signaling ◽  
Laron Syndrome ◽  
Rare Genetic Disorder ◽  
Igf I

Background : Laron & colleagues (1966) reported a rare genetic disorder in Israliei Jewish sublings which was characterized by insensitivity to growth hormone due to abnormality in growth hormone receptor or post receptor signaling pathway.Case Report: We hereby report a case of a 5 year old female child who presented to us with features similar to Laron syndrome. The diagnosis was made & confirmed by various Lab. investigations like low IGF-I levels and managed accordingly. JMS 2017; 20 (2):104-106  

Three novel Growth Hormone Receptor (GHR) splicing mutations causing a spectrum of Growth Hormone Insensitivity

2019 ◽  
Author(s):  
Emily Cottrell ◽  
Avinaash Maharaj ◽  
Tasneem Ladha ◽  
Sumana Chatterjee ◽  
Anna Grandone ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Splicing Mutations ◽  
Growth Hormone Insensitivity

Isolation of two types of cDNA encoding growth hormone receptor-like genes in the Japanese eel, Anguilla japonica

2002 ◽  
Vol 68 (sup1) ◽  
pp. 959-960 ◽  
Author(s):  
YUICHI OZAKI ◽  
HARUHISA FUKADA ◽  
YUKINORI KAZETO ◽  
SHINJI ADACHI ◽  
AKIHIKO HARA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Anguilla Japonica ◽  
Japanese Eel
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