scholarly journals Testosterone and oxidative stress: the oxidation handicap hypothesis

2006 ◽  
Vol 274 (1611) ◽  
pp. 819-825 ◽  
Author(s):  
Carlos Alonso-Alvarez ◽  
Sophie Bertrand ◽  
Bruno Faivre ◽  
Olivier Chastel ◽  
Gabriele Sorci
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Resistance ◽  
Secondary Sexual Traits ◽  
Honest Signals ◽  
Mixed Support ◽  
Immunocompetence Handicap Hypothesis ◽  
Handicap Hypothesis ◽  
The Cost

Secondary sexual traits (SST) are usually thought to have evolved as honest signals of individual quality during mate choice. Honesty of SST is guaranteed by the cost of producing/maintaining them. In males, the expression of many SST is testosterone-dependent. The immunocompetence handicap hypothesis has been proposed as a possible mechanism ensuring honesty of SST on the basis that testosterone, in addition to its effect on sexual signals, also has an immunosuppressive effect. The immunocompetence handicap hypothesis has received mixed support. However, the cost of testosterone-based signalling is not limited to immunosuppression and might involve other physiological functions such as the antioxidant machinery. Here, we tested the hypothesis that testosterone depresses resistance to oxidative stress in a species with a testosterone-dependent sexual signal, the zebra finch. Male zebra finches received subcutaneous implants filled with flutamide (an anti-androgen) or testosterone, or kept empty (control). In agreement with the prediction, we found that red blood cell resistance to a free radical attack was the highest in males implanted with flutamide and the lowest in males implanted with testosterone. We also found that cell-mediated immune response was depressed in testosterone-treated birds, supporting the immunocompetence handicap hypothesis. The recent finding that red blood cell resistance to free radicals is negatively associated with mortality in this species suggests that benefits of sexual signalling might trade against the costs derived from oxidation.

scholarly journals Twofold cost of reproduction: an increase in parental effort leads to higher malarial parasitaemia and to a decrease in resistance to oxidative stress

2011 ◽  
Vol 279 (1731) ◽  
pp. 1142-1149 ◽  
Author(s):  
Philippe Christe ◽  
Olivier Glaizot ◽  
Nicole Strepparava ◽  
Godefroy Devevey ◽  
Luca Fumagalli
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Brood Size ◽  
Parus Major ◽  
Cost Of Reproduction ◽  
Cell Resistance ◽  
Parental Effort ◽  
Brood Size Manipulation ◽  
Measured Resistance

Parental effort is usually associated with high metabolism that could lead to an increase in the production of reactive oxidative species giving rise to oxidative stress. Since many antioxidants involved in the resistance to oxidative stress can also enhance immune function, an increase in parental effort may diminish the level of antioxidants otherwise involved in parasite resistance. In the present study, we performed brood size manipulation in a population of great tits ( Parus major ) to create different levels of parental effort. We measured resistance to oxidative stress and used a newly developed quantitative PCR assay to quantify malarial parasitaemia. We found that males with an enlarged brood had significantly higher level of malarial parasites and lower red blood cell resistance to free radicals than males rearing control and reduced broods. Brood size manipulation did not affect female parasitaemia, although females with an enlarged brood had lower red blood cell resistance than females with control and reduced broods. However, for both sexes, there was no relationship between the level of parasitaemia and resistance to oxidative stress, suggesting a twofold cost of reproduction. Our results thus suggest the presence of two proximate and independent mechanisms for the well-documented trade-off between current reproductive effort and parental survival.

Effects of oxidative stress on red blood cell rheology in sickle cell patients

2014 ◽  
Vol 166 (4) ◽  
pp. 601-606 ◽  
Author(s):  
Régine Hierso ◽  
Xavier Waltz ◽  
Pierre Mora ◽  
Marc Romana ◽  
Nathalie Lemonne ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Cell Rheology

Utilization and Costs of Red Blood Cell Transfusions Pre- and Post-Azacitidine in Higher-Risk Myelodysplastic Syndromes

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4261-4261
Author(s):  
Eric Tseng ◽  
Soojin Seung ◽  
Nicole Mittmann ◽  
Jeannie Callum ◽  
Richard A. Wells ◽  
...  
Keyword(s):  
Blood Cell ◽  
Board Of Directors ◽  
Median Time ◽  
Red Blood Cell ◽  
Research Funding ◽  
Care Center ◽  
Tertiary Care ◽  
Advisory Committees ◽  
Transfusion Requirements ◽  
The Cost

Abstract Abstract 4261 Objectives: To determine the healthcare resources utilized and cost of red blood cell (RBC) transfusions pre- and post-azacitidine (AZA) treatment in patients with higher-risk myelodysplastic syndrome (MDS). Methods: A retrospective review of 51 MDS patients (3 low-risk, 9 Int-1, 26 Int-2, 13 high-risk) treated with AZA at our center was performed. Patients were followed from 6 months prior to and up to 18 months after initiation of AZA. We audited the clinical response rates and changes in transfusion requirements in higher-risk MDS patients treated with AZA at our tertiary care center. Clinical management information was obtained from our local institution and peripheral hospitals to document transfusion requirements pre- and post-AZA initiation. Health services utilized included transfusions (blood products), hospitalizations and medications. Canadian costs (2012 Canadian $) were applied to resources. The cost of RBC ($1273 per unit) transfusions is presented here. Results: 58.8% of MDS patients were male; 80.4% were ≥65 years. Patients received on average 11 cycles of AZA (IQR 7–17), with 54.9% of individuals receiving 9 or more cycles. Seven (14%) patients stopped AZA prematurely due to progressive disease (5), disease transformation (1), and toxicity (1). Median time to first response with AZA was 3 months; median time to best response was 6 months; and median time to progression was 10 months. Before AZA treatment, 62.7% were considered transfusion dependent (TD); 56% of the TD patients became transfusion independent within 12 months after starting AZA. 32 (62.7%) patients received RBCs six months prior to AZA initiation (mean 11.1 units/6 months; IQR 0–18). At 6 months post-AZA initiation, 41 (80.4%) of patients received RBCs (mean 10.8 units; IQR 1–17.5); between 6–12 months after AZA initiation, 26 (55.3%) patients (mean 7.8 units; IQR 0–11.5; 4 patients excluded for deaths/progression/lack of follow-up); and between 12–18 months, 14 (45.2%) patients (mean 6.7 units, IQR 0–11.5; 20 patients excluded). The cost per patient for RBC transfusions was $14,336 over the six months prior to AZA start, and $14,082, $10,533, $8,912 (1.8%; 35.3%; 62.7% reduction) at 6, 12 and 18 months after AZA initiation, respectively. Conclusions: At 6 months post-AZA initiation, more MDS patients received transfusions but fewer RBCs were transfused when compared to 6 months prior to AZA. At 12 and 18 months, fewer MDS patients received transfusions and fewer RBCs were used compared to both 6 months pre- and post-AZA administration. At 18 months, there was a 63% reduction in RBC costs from pre-AZA initiation. Disclosures: Seung: Celgene: Research Funding. Mittmann:Celgene: Research Funding. Wells:Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Alexion: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Kim:Celgene: Employment. Buckstein:Celgene: Honoraria, Research Funding.

Indicator Characterizing Carbonyl-Dependent Modification of Erythrocytic Superoxydismutase as a Biochemical Marker of Oxidative Stress in Coronary Heart Disease

Kardiologiia ◽  
2020 ◽  
Vol 60 (5) ◽  
pp. 57-61
Author(s):  
A. K. Tikhaze ◽  
V. Ya. Kosach ◽  
V. Z. Lankin ◽  
A. A. Panferova ◽  
M. D. Smirnova
Keyword(s):  
Oxidative Stress ◽  
Heart Disease ◽  
Stress Intensity ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Oxidative Modification ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Sod Activity ◽  
Stress Marker

Aim To study the oxidative modification of red blood cell Cu,Zn superoxide dismutase (SOD) in patients with ischemic heart disease (IHD) in vivo and in vitro to substantiate the use of a new oxidative stress marker.Material and methods Red blood cell Cu,Zn SOD was measured by depression of nitrotetrazolium blue reduction by the superoxide anion generated in xanthine oxidase xanthine oxidation. Red blood cell Cu,Zn SOD was measured immunochemically. The biochemical study was performed in the control group (patients with low extremity fracture without known history of cardiovascular diseases and hyperlipidemia) and in groups of patients with acute myocardial infarction, stable angina, and decompensated heart failure. For evaluation of oxidative stress intensity in IHD patients, an empirical SOD oxidative modification coefficient (OMCSOD) was proposed, which is a Cu,Zn SOD activity / Cu,Zn SOD content ratio.Results The red blood cell Cu,Zn SOD activity was significantly decreased in all IHD groups compared to the control group. Furthermore, OMCSOD was also considerably decreased in IHD patients, which warrants the use of this biochemical index as an oxidative stress marker.Conclusion It was shown that the Cu,Zn SOD modification was induced by interaction of the enzyme molecules with a natural dicarbonyl, malonic dialdehyde, and OMCSOD can be used for evaluation of oxidative stress intensity in IHD patients.

scholarly journals Iron-deficiency anaemia enhances red blood cell oxidative stress

2008 ◽  
Vol 42 (9) ◽  
pp. 824-829 ◽  
Author(s):  
Enika Nagababu ◽  
Seema Gulyani ◽  
Christopher J. Earley ◽  
Roy G. Cutler ◽  
Mark P. Mattson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

2011 ◽  
Vol 71 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Bülent Kücükakin ◽  
Volkan Kocak ◽  
Jens Lykkesfeldt ◽  
Hans J. Nielsen ◽  
Karin Magnussen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Components ◽  
Biomarkers Of Oxidative Stress

scholarly journals Luspatercept (Reblozyl)

2021 ◽  
Vol 1 (12) ◽  
Author(s):  
Reimbursement Team
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Myelodysplastic Syndromes ◽  
Adult Patients ◽  
Intermediate Risk ◽  
Ring Sideroblasts ◽  
The Cost ◽  
Public Drug

CADTH recommends that Reblozyl should be reimbursed by public drug plans for the treatment of adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS)-associated anemia who have ring sideroblasts and require red blood cell (RBC) transfusions, if certain conditions are met. Reblozyl should only be covered to treat patients who have failed or are not suitable for erythropoietin-based therapy. Reblozyl should only be reimbursed if prescribed by a specialist in MDS and if the cost of Reblozyl is reduced. Reimbursement should only be renewed if Reblozyl shows benefit to the patient such that the patient no longer requires RBC transfusions.

Sign in / Sign up

Export Citation Format

Share Document