scholarly journals ALOX5 , LPA , MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans

2020 ◽  
Vol 7 (1) ◽  
pp. 190775
Author(s):  
Rafael Camacho-Mejorado ◽  
Rocío Gómez ◽  
Luisa E. Torres-Sánchez ◽  
Esther Alhelí Hernández-Tobías ◽  
Gino Noris ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Native Americans ◽  
Gene Polymorphisms ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Healthy Group ◽  
And Gender ◽  
And Oxidative Stress

Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group ( n = 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included. ALOX5 , LPA , MMP9 and TPO gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of ALOX5 , LPA , MMP9 and TPO polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.

scholarly journals Depressive symptoms are associated with oxidative stress in middle-aged women: a cross-sectional study

2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Asuka Hirose ◽  
Masakazu Terauchi ◽  
Mihoko Akiyoshi ◽  
Yoko Owa ◽  
Kiyoko Kato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Depressive Symptoms ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional

scholarly journals Racial/ethnic, gender, and age group differences in cardiometabolic risks among adults in a Northern California health plan: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nancy P. Gordon ◽  
Loretta Hsueh
Keyword(s):  
Gender Differences ◽  
Ethnic Groups ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Chinese Adults ◽  
Exercise Frequency ◽  
Cross Sectional ◽  
Cardiometabolic Risks ◽  
And Gender ◽  
Racial Ethnic

Abstract Background In the U.S., the prevalence of diabetes and hypertension are higher among African American/Black (Black), Latinx, and Filipino adults than non-Hispanic White (White) and Chinese adults. We compared the racial/ethnic-specific prevalence of several modifiable cardiometabolic risks in an insured adult population to identify behaviors that may drive racial/ethnic differences in cardiometabolic health. Methods This cross-sectional study used data for middle-aged (35–64) and older (65–79) Kaiser Permanente Northern California (KPNC) adult health plan members. Smoking status and BMI were derived from electronic health record data. Weighted pooled self-reported data from the 2014/2015 and 2017 KPNC Member Health Survey cycles were used to estimate daily number of servings of fruits/vegetables, general sodium avoidance, sugar-sweetened beverage (SSB) consumption frequency, alcohol use within daily recommended limit, weekly exercise frequency, and number of hours of sleep daily. Age-standardized estimates of all cardiometabolic risks were produced for middle-aged and older-aged women and men in the five racial/ethnic groups. Analyses focused on racial/ethnic differences within age-gender groups and gender and age group differences within racial/ethnic groups. Results In both age groups, Black, Latinx, and Filipino adults were more likely than White and Chinese adults to have overweight and obesity and were less likely to engage in health promoting dietary (fruit/vegetable and SSB consumption, sodium avoidance (women only)) and sleep behaviors. Middle-aged Black and Filipino men were more likely than White men to be current smokers. Less racial/ethnic variation was seen in exercise frequency. Significant gender differences were observed for dietary behaviors overall and within racial/ethnic groups, especially among middle-aged adults; however, these gender differences were smaller for sleep and exercise. Age differences within gender and racial/ethnic groups were less consistent. Racial/ethnic and gender differences in these behaviors were also seen in the subsample of adults with diabetes and/or hypertension and in the subsample of adults who reported they were trying to engage in health promoting behaviors. Conclusions Black, Latinx, and Filipino adults were more likely than White and Chinese adults to report dietary and sleep behaviors associated with development and worsening of cardiometabolic conditions, with men exhibiting poorer dietary behaviors than women.

scholarly journals High ferritin in homozygous and heterozygous β-thalassemia tends to decrease oxidative stress levels

2018 ◽  
Vol 37 (2) ◽  
pp. 97
Author(s):  
Ani Melani Maskoen ◽  
Lelani Reniarti ◽  
Nur Imaniati Sumantri ◽  
Edhyana Sahiratmadja
Keyword(s):  
Oxidative Stress ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Stress Markers ◽  
Stress Levels ◽  
Spearman Correlation Test ◽  
Multiple Blood ◽  
High Level ◽  
And Oxidative Stress

Background<br />Ineffective erythropoiesis and multiple blood transfusions may cause iron overload, leading to high level of ferritin in â-thalassemia patients. Iron has the ability to catalyze the production of reactive oxygen species (ROS), which can be prevented by an adequate activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx). The aim of this study was to explore the association between high ferritin levels and oxidative stress among â-thalassemia patients by measuring SOD and GPx levels.<br /><br />Methods<br />This was a cross sectional study among â-thalassemia major patients. Ferritin, SOD, and GPx were measured and compared between â-thalassemia patients with homozygous IVS1nt5 and heterozygous IVS1nt5/HbE mutations, which were the most prevalent mutations found in our previous study. The Spearman correlation test was used to analyze the data.<br /><br />Results<br />The ferritin levels in all â-thalassemia major patients were very high (range: 791-12,340 ìg/L). However, no significant differences were observed (p=0.318) between homozygous IVS1nt5 (n=45) compared to heterozygous IVS1nt5/HbE (n=13). The oxidative stress markers SOD and GPx were not significantly different between homozygous IVS1nt5 and heterozygous IVS1nt5/HbE (p=0.450 and p=0.323, respectively). The correlations between ferritin and SOD and GPx oxidative stress levels were not significant in both homozygous IVS1nt5 and heterozygous IVS1nt5/HbE mutations.<br /><br />Conclusion<br />High ferritin levels in â-thalassemia patients tend to decrease the GPx level in all thalassemia patients and SOD level in half of the patients, indicating that GPx and SOD may play a role in the occurrence of oxidative stress among thalassemia patients. The mechanism of oxidative stress in thalassemia needs to be further explored.

scholarly journals Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: a cross-sectional study

2019 ◽  
Author(s):  
Martha A. Sánchez-Rodríguez ◽  
Mariano Zacarías-Flores ◽  
Alicia Arronte-Rosales ◽  
Víctor Manuel Mendoza-Núñez
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Women ◽  
Hot Flashes ◽  
Premenopausal Women ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Self Rating ◽  
Stress Score ◽  
And Oxidative Stress

AbstractObjectiveTo assess the association between hot flashes (HFs) severity and oxidative stress (OS) in Mexican postmenopausal women.MethodsA cross-sectional study was carried out with perimenopausal women aged 40-59 years community-dwelling from Mexico City, Mexico. They participated in Menopause and Oxidative Stress Project. The baseline sample consisted of 476 women recruited to participate; 161 women were excluded due to different reasons. Hence, 315 women were selected to establish two groups, a) 145 premenopausal women (yet with menstrual bleeding), and b) 170 postmenopausal women (without menses). All women were free of cardiovascular, kidney, hepatic or cancer disease, and without antioxidant supplement intake for at least six months prior to the beginning of the study; none had previously received hormone therapy. As OS markers, we measured plasma malondialdehyde using the TBARS assay, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx), uric acid, and total antioxidant status; also, we calculated SOD/GPx ratio, antioxidant gap and an oxidative stress score ranging from 0 to 7. The HFs were evaluated using the Menopause Rating Scale. The women completed Spanish version of the Athens Insomnia Scale, Zung Self-Rating Anxiety Scale and Zung Self-Rating Depression Scale and a questionnaire of pro-oxidant factors.ResultsStress score increased with HFs severity (mild 2.9±0.23, moderate 3.1±0.21 and severe 3.8±0.18, p<0.01) in postmenopausal women. We observed a positive correlation between HFs severity and stress score, r=0.247 (p=0.001) in postmenopausal women; other test scores were not correlated. Severe HFs were a risk factor for OS (OR=3.37, 95%CI: 1.20-9.51, p<0.05) in an adjusted multivariate analysis by different postmenopausal symptoms and pro-oxidant factors; we did not see any association in premenopausal women.ConclusionOur findings suggest an association between HFs severity and OS in Mexican postmenopausal women.

Sign in / Sign up

Export Citation Format

Share Document