scholarly journals New MRI contrast agents based on silicon nanotubes loaded with superparamagnetic iron oxide nanoparticles

2018 ◽  
Vol 5 (8) ◽  
pp. 180697 ◽  
Author(s):  
Roberto Gonzalez-Rodriguez ◽  
Petra Granitzer ◽  
Klemens Rumpf ◽  
Jeffery L. Coffer
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Negative Contrast ◽  
Superparamagnetic Iron Oxide ◽  
Aqueous Solubility ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Silicon Nanotubes ◽  
Magnetic Resonance Imaging Contrast ◽  
Negative Contrast Agent

This article describes the preparation and fundamental properties of a new possible material as a magnetic resonance imaging contrast agent based on the incorporation of preformed iron oxide (Fe 3 O 4 ) nanocrystals into hollow silicon nanotubes (Si NTs). Specifically, superparamagnetic Fe 3 O 4 nanoparticles of two different average sizes (5 nm and 8 nm) were loaded into Si NTs of two different shell thicknesses (40 nm and 70 nm). To achieve proper aqueous solubility, the NTs were functionalized with an outer polyethylene glycol-diacid (600) moiety via an aminopropyl linkage. Relaxometry parameters r 1 and r 2 were measured, with the corresponding r 2 / r 1 ratios in phosphate buffered saline confirming the expected negative contrast agent behaviour for these materials. For a given nanocrystal size, the observed r 2 values are found to be inversely proportional to NT wall thickness, thereby demonstrating the role of nanostructured silicon template on associated relaxometry properties.

scholarly journals Iron oxide nanoparticles stabilized with dendritic polyglycerols as selective MRI contrast agents

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9646-9654 ◽  
Author(s):  
Daniel Nordmeyer ◽  
Patrick Stumpf ◽  
Dominic Gröger ◽  
Andreas Hofmann ◽  
Sven Enders ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.

scholarly journals Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14051-14059
Author(s):  
Abdulrahman Ahmed Mahmood ◽  
Jianqi Zhang ◽  
Rufang Liao ◽  
Xiwei Pan ◽  
Dan Xu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Contrast Agent ◽  
Cancer Diagnosis ◽  
Liver Tumors ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Potential Toxicity ◽  
Mri Contrast ◽  
Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

scholarly journals Digital Simulation Assessments of the Sensitivity of Quantitative MRI for Detection of an Iron Oxide Nanoparticle Brain MRI Contrast Agent

2021 ◽  
Author(s):  
Joong Kim ◽  
Wen-Tung Wang ◽  
Andrew Knutsen ◽  
David Brody
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Digital Simulation ◽  
Brain Mri ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Simulation Approach ◽  
Mri Contrast ◽  
Mr Relaxation

Abstract There have been substantial efforts to develop targeted exogenous MRI contrast agents to assess specific brain pathologies. In parallel with other efforts, it is important to assess the sensitivity of candidate MRI methods for detection of contrast agents. Here, we propose a digital simulation approach, which includes MR relaxation (R1 and R2) mapping and image co-registration. We simulated the effects of 3 nm iron oxide nanoparticles (IONPs) as a model contrast agent. Two independent relaxation maps acquired from the brain of the same subject were co-registered. The baseline subtraction between the two relaxation maps showed good agreement, demonstrating the high reproducibility of the method. Next, the second relaxation map was digitally altered (“seeded”) to simulate additional MR relaxation values corresponding to several concentrations of 3 nm IONPs in various locations. The maps of absolute differences between the first relaxation map and the digitally altered second relaxation maps were assessed for conspicuity. Results based on living mouse and human brains scanned at 9.4 T and 3.0 T respectively both indicated reliable conspicuity for signal equivalent to 0.06 mM IONP or higher. Overall, the digital simulation approach is a useful method to improve the development of MRI contrast agents and accompanying MRI methodologies.

Magnetically modified bentonite as a possible contrast agent in MRI of gastrointestinal tract

2007 ◽  
Vol 61 (5) ◽  
Author(s):  
H. Bartonkova ◽  
M. Mashlan ◽  
I. Medrik ◽  
D. Jancik ◽  
R. Zboril
Keyword(s):  
Mössbauer Spectroscopy ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Mossbauer Spectroscopy ◽  
Oxide Particle ◽  
Negative Contrast ◽  
Iron Oxide Particle ◽  
Hyperfine Parameters ◽  
Mößbauer Spectroscopy ◽  
Negative Contrast Agent

AbstractA composite of iron oxide nanoparticles and mineral matrix has been studied by XRD, Mössbauer spectroscopy, and TEM. Magnetite and superparamagnetic magnetite have been identified by Mössbauer spectroscopy in the nanocomposite. A relationship between the hyperfine parameters and iron oxide particle size has been confirmed by TEM. The optimal concentration of “magnetite—bentonite” composite, when the MRI signal is fully reduced, was found for using this composite as a negative contrast agent.

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