scholarly journals Synthesis and characterization of azo-guanidine based alcoholic media naked eye DNA sensor

2016 ◽  
Vol 3 (11) ◽  
pp. 160351 ◽  
Author(s):  
Ataf Ali Altaf ◽  
Uzma Hashmat ◽  
Muhammad Yousaf ◽  
Bhajan Lal ◽  
Shafiq Ullah ◽  
...  
Keyword(s):  
Binding Constants ◽  
Blue Shift ◽  
Dna Sensing ◽  
H Nmr ◽  
Naked Eye ◽  
Uv Visible ◽  
New Compounds ◽  
Synthesized Materials ◽  
Dna Binding Properties

DNA sensing always has an open meadow of curiosity for biotechnologists and other researchers. Recently, in this field, we have introduced an emerging class of molecules containing azo and guanidine functionalities. In this study, we have synthesized three new compounds ( UA1 , UA6 and UA7 ) for potential application in DNA sensing in alcoholic medium. The synthesized materials were characterized by elemental analysis, FTIR, UV-visible, 1 H NMR and 13 C NMR spectroscopies. Their DNA sensing potential were investigated by UV-visible spectroscopy. The insight of interaction with DNA was further investigated by electrochemical (cyclic voltammetry) and hydrodynamic (viscosity) studies. The results showed that compounds have moderate DNA binding properties, with the binding constants range being 7.2 × 10 3 , 2.4 × 10 3 and 0.2 × 10 3  M −1 , for UA1 , UA6 and UA7 , respectively. Upon binding with DNA, there was a change in colour (a blue shift in the λ max value) which was observable with a naked eye. These results indicated the potential of synthesized compounds as DNA sensors with detection limit 1.8, 5.8 and 4.0 ng µl −1 for UA1 , UA6 and UA7 , respectively.

Synthesis and spectral properties of ruthenium(II) complexes with tetra-15-crown-5-phthalocyanine and N-donor ligands

2003 ◽  
Vol 07 (12) ◽  
pp. 795-800 ◽  
Author(s):  
Yuliya G. Gorbunova ◽  
Yuliya Yu. Enakieva ◽  
Sergey G. Sakharov ◽  
Aslan Yu. Tsivadze
Keyword(s):  
Spectral Properties ◽  
Donor Ligands ◽  
Preparation Technique ◽  
Reaction Products ◽  
H Nmr ◽  
Trimethylamine Oxide ◽  
Donor Solvent ◽  
Ft Ir ◽  
Uv Visible

The synthesis of novel bis-axially coordinated ruthenium(II) complexes with tetra-15-crown-5-phthalocyanine and N-donor ligands ( R 4 Pc ) Ru ( L 2) ( R 4Pc2- = 4,5,4',5',4'',5'', 4''',5'''- tetrakis(1,4,7,10,13-pentaoxotridecamethylene)phthalocyaninate-ion, L = pyridine (py), isoquino-line (iqnl), triethylamine ( Et 3 N )) is reported. The preparation technique involves the interaction of ( R 4 Pc ) Ru ( CO )( CH 3 OH ) with trimethylamine oxide in an N-donor solvent. The advantage of this method consists in selective carbonyl ejection from ( R 4 Pc ) Ru ( CO ) X with simultaneous substi-tution by N-donor ligands. The application of this procedure allowed us to decrease essentially the reaction time, as compared with photochemical methods, as well as to increase substantially the yield of reaction products. UV-visible, 1 H NMR, FT-IR and mass-spectrometry were used for characterization of the obtained compounds.

Synthesis and Electrochemistry of Aluminum Porphycenes: Crystal and Molecular Structure of Methyl-σ-Bonded Aluminum Etioporphycene

1997 ◽  
Vol 01 (02) ◽  
pp. 109-119 ◽  
Author(s):  
ROGER GUILARD ◽  
VIRGINIE PICHON-PESME ◽  
HASSANE LACHEKAR ◽  
CLAUDE LECOMTE ◽  
ALLY M. AUKAULOO ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Crystal And Molecular Structure ◽  
Structural Data ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
H Nmr ◽  
Axial Ligands ◽  
Uv Visible

The synthesis and characterization of three monomeric aluminum porphycenes with anionic or σ-bonded axial ligands is reported. The investigated compounds are represented as ( EtioPc ) Al ( CH 3) and ( EtioPc ) AlX where EtioPc represents the dianion of etioporphycene and X = Cl − or OH −. Each synthesized complex was characterized by mass spectrometry. 1 H NMR, IR and UV-visible spectroscopies as well as by electrochemistry. Comparisons are made between the properties of complexes in the aluminum etioporphycene series and related chloro- or methyl σ-bonded Al ( III ) porphyrins containing octaethylporphyrin ( OEP ) or tetraphenylporphyrin ( TPP ) macrocycles. Comparisons are also made between the currently investigated compounds and a previously reported Al ( III ) μ-oxo dimer, [( EtioPc ) Al ]2 O . In addition, the crystal and molecular structure of ( EtioPc ) Al ( CH 3) was determined by X-ray diffraction. The molecular structure of this methyl-σ-bonded aluminum etioporphycene provides the first structural data for an aluminum porphycene compound. The aluminum(III) atom in ( EtioPc ) Al ( CH 3) is pentacoordinated and is located 0.54 Å from the plane of the four N -nitrogens.

Synthesis and characterization of N-glucosylated dithiadiazepine derivatives through carbon-sulfur bond formation

2015 ◽  
Vol 21 (5) ◽  
pp. 269-272 ◽  
Author(s):  
Snehal A. Chavan ◽  
Avinash G. Ulhe ◽  
Baliram N. Berad
Keyword(s):  
Bond Formation ◽  
Synthesis And Characterization ◽  
Mass Spectral ◽  
H Nmr ◽  
Chemical Structures ◽  
Elemental Analyses ◽  
New Compounds ◽  
Sulfur Bond ◽  
C Nmr

AbstractNew 4,7-bis(arylamino)-2-tetra-O-acetyl-β-d-glucopyranosylimino-1,3,5,6-dithiadiazepines were synthesized via reaction of N-tetra-O-acetyl-β-d-glucopyranosyl isocyanodichloride with 1,6-diaryl-2,5-dithio-bis-ureas without using any catalyst. Thus, the synthesis of 7-membered heterocycles containing two sulfur and two nitrogen atoms through carbon-sulfur bond formation was explored. The chemical structures of these new compounds were elucidated by IR, 1H NMR, 13C NMR, mass spectral, and elemental analyses.

scholarly journals Structural characterization and DNA-binding properties of Sm(III) complex with ofloxacin using spectroscopic methods

2009 ◽  
Vol 23 (2) ◽  
pp. 103-111 ◽  
Author(s):  
Changyun Chen ◽  
Kai Chen ◽  
Qi Long ◽  
Meihua Ma ◽  
Fei Ding
Keyword(s):  
Binding Sites ◽  
Nmr Spectra ◽  
Uv Spectroscopy ◽  
Binding Constants ◽  
Binding Properties ◽  
H Nmr ◽  
Elemental Analyses ◽  
Displacement Experiments ◽  
Ct Dna ◽  
Dna Binding Properties

A novel complex Sm(III) complex with ofloxacin was synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, thermal analysis (TG-DSC),1H-NMR spectra. Then, spectrometric titration, ethdium bromide displacement experiments by UV spectroscopy, ionic influence, viscosity measurements and Circular Dichroism (CD) spectroscopic measurements were conducted to characterize the interaction between the complex and CT-DNA. Results obtained indicate that the complex bound with CT-DNA via an intercalation mechanism. The binding constants and binding sites number of the Sm(III) complex with CT-DNA were 1.80×105l·mol−1and 1, respectively.

Titanocene derivatives of purine and adenine. Synthesis and characterization of reaction products with (η5-C5H5)2Ti(CO)2, (η5-C5H5)2TiCl, and (η5-C5H5)2TiCl2

1986 ◽  
Vol 64 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Daniel Cozak ◽  
Abdelhakim Mardhy ◽  
André Morneau
Keyword(s):  
Carbon Monoxide ◽  
Metal Complex ◽  
Elemental Analysis ◽  
Synthesis And Characterization ◽  
Reaction Products ◽  
First Order ◽  
H Nmr ◽  
New Compounds ◽  
Derivatives Of

The reaction of CpTi(CO)2 (1), Cp2TiCl (2), and Cp2TiCl2 (3) (Cp = η5-C5H5) with purine (PuH) and adenine (AdH) in organic solvents is described. The compound 1 reacts with both molecules in an oxidative fashion giving Cp2Ti(C5H3N4)(C5H4N4) (4) and (Cp2Ti)2(C5H3N5) (5) with concomitant liberation of molecular carbon monoxide and hydrogen (4:1) following a first order rate law in metal complex. The compound 2 forms an adduct compound Cp2TiCl(C5H4N4) (6) with PuH. Monosubstituted derivatives Cp2TiCl(C5H3N4) (7) and Cp2TiCl(C5H4N5) (8) are formed from the reaction of the deprotonated bases with 3. In addition to the usual elemental analysis, the characteristic ir, 1H nmr, epr, and ms results are given for the new compounds.

Tungsten and molybdenum oxo complexes of tetrakis(phenyldiazenyl)calix[4]arene substituted derivatives: EHMO calculations, spectroscopic characterization, and perturbations of the photophysical properties by neutral guest molecules

1996 ◽  
Vol 74 (11) ◽  
pp. 2279-2288 ◽  
Author(s):  
Pierre D. Harvey ◽  
Jonathan Gagnon ◽  
Réjean Provencher ◽  
Bing Xu ◽  
Timothy M. Swager
Keyword(s):  
Excited States ◽  
Photophysical Properties ◽  
Binding Constants ◽  
Spectroscopic Characterization ◽  
Guest Molecules ◽  
H Nmr ◽  
Oxo Complexes ◽  
Visible Luminescence ◽  
Uv Visible ◽  
Host Chemistry

Bowl-shaped chromophores fabricated with tungsten and molybdenum oxo complexes of calix[4]arenes substituted at the para positions with phenyldiazenyl (R2C6H3N2) derivatives are investigated. The nature of the lowest energy excited states has been addressed theoretically using Extended Hückel Molecular Orbital (EHMO) calculations and experimentally using UV-visible, luminescence, and polarized emission spectroscopy at 77 K. The lowest energy excited states are intraligand (azobenzene fragment) ππ* (S2 and T2) and ππ*states (S1, and T1). The compounds are weakly luminescent in the 600–630 nm range exhibiting emissions arising from the 1(ππ*) states [Formula: see text]. The region located above 900 nm was not investigated. Evidence for guest–host chemistry has been demonstrated by1H-NMR spectroscopy, and the binding constants for two of the compounds with pyridine in toluene as a solvent were obtained by UV–visible spectroscopy. The presence of a guest molecule inside the luminescent metal oxo complex of a calix[4]arene hosts decreases the emission lifetimes.Key words: host–guest, photophysics, calix[4]arene, EHMO, fluorescence

scholarly journals CuAAC-based assembly and characterization of a ruthenium–copper dyad containing a diimine–dioxime ligand framework

2017 ◽  
Vol 198 ◽  
pp. 251-261 ◽  
Author(s):  
Nicolas Queyriaux ◽  
Eugen S. Andreiadis ◽  
Stéphane Torelli ◽  
Jacques Pecaut ◽  
Brad S. Veldkamp ◽  
...  
Keyword(s):  
Transient Absorption ◽  
Light Activation ◽  
Visible Absorption ◽  
H Nmr ◽  
Steady State Fluorescence ◽  
Molecular Dyads ◽  
Uv Visible ◽  
Photocatalytic Applications ◽  
Copper Centre

The design of molecular dyads combining a light-harvesting unit with an electroactive centre is highly demanded in the field of artificial photosynthesis. The versatile Copper-catalyzed Azide–Alkyne Cycloaddition (CuAAC) procedure was employed to assemble a ruthenium tris-diimine unit to an unprecedented azide-substituted copper diimine–dioxime moiety. The resulting RuIICuII dyad 4 was characterized by electrochemistry, 1H NMR, EPR, UV-visible absorption, steady-state fluorescence and transient absorption spectroscopies. Photoinduced electron transfer from the ruthenium to the copper centre upon light-activation in the presence of a sacrificial electron donor was established thanks to EPR-monitored photolysis experiments, opening interesting perspectives for photocatalytic applications.

scholarly journals Structural and Surface Characterization of Newly Synthesized D-π-D Type Schiff Base Ligand: (1E,2E)-3-[4-(Dimethylamino)phenyl]prop-2-en-1-ylidene)phenylamine

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Gulsah Gumrukcu ◽  
Serkis Garikyan ◽  
Gulnur Keser Karaoglan ◽  
Dolunay Sakar
Keyword(s):  
Schiff Base ◽  
Surface Properties ◽  
Schiff Base Ligand ◽  
Mass Spectra ◽  
Surface Characterization ◽  
Acid Base ◽  
H Nmr ◽  
Elemental Analyses ◽  
Uv Visible

A new Schiff base with D-π-D type, (1E,2E)-3-[4-(dimethylamino)phenyl]prop-2-en-1-ylidene)phenylamine, has been successfully synthesized using the reaction of (2E)-3-[4-(dimethylamino)phenyl]acrylaldehyde with aniline. The Schiff base ligand has been characterized by FTIR, UV-visible, and1H NMR as well as TG/DTA, SEM, BET, and elemental analyses and mass spectra. Surface properties and acid-base constants of Schiff base ligand were determined by IGC measurements.

Synthesis and characterization of novel metal-free and metallophthalocyanines peripherally fused to four 24-membered tetraoxatetraaza macrocycles

2001 ◽  
Vol 05 (04) ◽  
pp. 367-375 ◽  
Author(s):  
S. ZEKİ YILDIZ ◽  
HALTİ KANTEKİN ◽  
YAŞAR GÖK
Keyword(s):  
Elemental Analysis ◽  
Metal Salt ◽  
Synthesis And Characterization ◽  
Organic Base ◽  
Metal Free ◽  
H Nmr ◽  
New Compounds ◽  
Derivatives Of ◽  
C Nmr

New metal-free 5 and metallophthalocyanines 6-11( M = Cu , Ni , Co , Pb , Zn ) fused in peripheral positions with four 24-membered tetraoxatetraaza macrocycles were prepared by cyclotetramerization of 24,25-dicyano-4,10,13,17-tetra(toluene-p-sulfonyl)-1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22-didicontinehydrobenzo[y][3,9,12,18]tetraaza[1,7,16,22]tetraoxatetradicontine in the presence of the corresponding metal salt or a strong organic base. While the N-tosylated derivatives of the phthalocyanines are soluble in common organic solvents, the detosylated derivative of copper phthalocyaninate is soluble in water. The aggregation properties of the phthalocyanines were also investigated as a function of concentration, solvent and oxidative medium. The new compounds are characterized by a combination of elemental analysis and 1 H NMR, 13 C NMR, IR, UV-vis and MS spectral data.

vic-Diacrylic ester porphyrins as starting materials for monobenzoporphyrin and opp-dibenzoporphyrin syntheses

1998 ◽  
Vol 76 (8) ◽  
pp. 1215-1219 ◽  
Author(s):  
Arezki Boudif ◽  
Sandrine Gimenez ◽  
Bernard Loock ◽  
Michel Momenteau
Keyword(s):  
H Nmr ◽  
Step Procedure ◽  
Uv Visible ◽  
Synthesis Methodology

Synthesis of a bis(vic-diacrylic ester) porphyrin using the "3+1" methodology is described. A two-step procedure is used to convert the vic-diacrylic ester porphyrin and the bis(vic-diacrylic ester) porphyrin to the monobenzoporphyrin and the opp-dibenzoporphyrin, respectively. Characterization of the compounds by 1H NMR and UV-visible spectroscopies is also discussed.Key words: tripyrrane, diformylpyrrole, vic-diacrylic ester porphyrin, "3+1" synthesis methodology, monobenzoporphyrin, opp-dibenzoporphyrin, photosensitizer.

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