scholarly journals Growth and remodelling of living tissues: perspectives, challenges and opportunities

2019 ◽  
Vol 16 (157) ◽  
pp. 20190233 ◽  
Author(s):  
Davide Ambrosi ◽  
Martine Ben Amar ◽  
Christian J. Cyron ◽  
Antonio DeSimone ◽  
Alain Goriely ◽  
...  
Keyword(s):  
Time Scales ◽  
Early Life ◽  
Soft Tissues ◽  
Surgical Intervention ◽  
Living Matter ◽  
Future Directions ◽  
Current State ◽  
Challenges And Opportunities ◽  
Living Tissues ◽  
Short Time

One of the most remarkable differences between classical engineering materials and living matter is the ability of the latter to grow and remodel in response to diverse stimuli. The mechanical behaviour of living matter is governed not only by an elastic or viscoelastic response to loading on short time scales up to several minutes, but also by often crucial growth and remodelling responses on time scales from hours to months. Phenomena of growth and remodelling play important roles, for example during morphogenesis in early life as well as in homeostasis and pathogenesis in adult tissues, which often adapt to changes in their chemo-mechanical environment as a result of ageing, diseases, injury or surgical intervention. Mechano-regulated growth and remodelling are observed in various soft tissues, ranging from tendons and arteries to the eye and brain, but also in bone, lower organisms and plants. Understanding and predicting growth and remodelling of living systems is one of the most important challenges in biomechanics and mechanobiology. This article reviews the current state of growth and remodelling as it applies primarily to soft tissues, and provides a perspective on critical challenges and future directions.

scholarly journals Biomedical informatics meets data science: current state and future directions for interaction

JAMIA Open ◽  
2018 ◽  
Vol 1 (2) ◽  
pp. 136-141 ◽  
Author(s):  
Philip R O Payne ◽  
Elmer V Bernstam ◽  
Justin B Starren
Keyword(s):  
Big Data ◽  
Data Science ◽  
Clinical Decision Making ◽  
Social Issues ◽  
Biomedical Informatics ◽  
Scientific Discovery ◽  
Topic Area ◽  
Future Directions ◽  
Current State ◽  
Challenges And Opportunities

Abstract There are an ever-increasing number of reports and commentaries that describe the challenges and opportunities associated with the use of big data and data science (DS) in the context of biomedical education, research, and practice. These publications argue that there are substantial benefits resulting from the use of data-centric approaches to solve complex biomedical problems, including an acceleration in the rate of scientific discovery, improved clinical decision making, and the ability to promote healthy behaviors at a population level. In addition, there is an aligned and emerging body of literature that describes the ethical, legal, and social issues that must be addressed to responsibly use big data in such contexts. At the same time, there has been growing recognition that the challenges and opportunities being attributed to the expansion in DS often parallel those experienced by the biomedical informatics community. Indeed, many informaticians would consider some of these issues relevant to the core theories and methods incumbent to the field of biomedical informatics science and practice. In response to this topic area, during the 2016 American College of Medical Informatics Winter Symposium, a series of presentations and focus group discussions intended to define the current state and identify future directions for interaction and collaboration between people who identify themselves as working on big data, DS, and biomedical informatics were conducted. We provide a perspective concerning these discussions and the outcomes of that meeting, and also present a set of recommendations that we have generated in response to a thematic analysis of those same outcomes. Ultimately, this report is intended to: (1) summarize the key issues currently being discussed by the biomedical informatics community as it seeks to better understand how to constructively interact with the emerging biomedical big data and DS fields; and (2) propose a framework and agenda that can serve to advance this type of constructive interaction, with mutual benefit accruing to both fields.

scholarly journals The current state and future directions of percolation leaching in the Chinese mining industry: Challenges and opportunities

2018 ◽  
Vol 125 ◽  
pp. 206-222 ◽  
Author(s):  
I.M.S.K. Ilankoon ◽  
Yuan Tang ◽  
Yousef Ghorbani ◽  
Stephen Northey ◽  
Mohan Yellishetty ◽  
...  
Keyword(s):  
Mining Industry ◽  
Future Directions ◽  
Current State ◽  
Challenges And Opportunities

scholarly journals What do cells regulate in soft tissues on short time scales?

2021 ◽  
Author(s):  
Jonas F. Eichinger ◽  
Daniel Paukner ◽  
Roland C. Aydin ◽  
Wolfgang A. Wall ◽  
Jay D. Humphrey ◽  
...  
Keyword(s):  
Time Scales ◽  
Soft Tissues ◽  
Short Time

Autonomous vehicles and freight traffic: towards better efficiency of road, rail or urban logistics?

2018 ◽  
Vol 58 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Péter Bucsky
Keyword(s):  
Autonomous Vehicles ◽  
Road Transport ◽  
Transport Sector ◽  
Future Directions ◽  
Car Industry ◽  
Level Of Automation ◽  
Current State ◽  
Freight Traffic ◽  
Levels Of Automation ◽  
Private Car

Abstract The freight transport sector is a low profit and high competition business and therefore has less ability to invest in research and development in the field of autonomous vehicles (AV) than the private car industry. There are already different levels of automation technologies in the transport industry, but most of these are serving niche demands and answers have yet to be found about whether it would be worthwhile to industrialise these technologies. New innovations from different fields are constantly changing the freight traffic industry but these are less disruptive than on other markets. The aim of this article is to show the current state of development of freight traffic with regards to AVs and analyse which future directions of development might be viable. The level of automation is very different in the case of different transport modes and most probably the technology will favour road transport over other, less environmentally harmful traffic modes.

The Spread of Pollutants from Harbour Sludge Depots

1984 ◽  
Vol 16 (3-4) ◽  
pp. 623-633
Author(s):  
M Loxham ◽  
F Weststrate
Keyword(s):  
Time Scales ◽  
Molecular Diffusion ◽  
Near Field ◽  
Parameter Analysis ◽  
Migration Patterns ◽  
Long Time ◽  
Dilution Effects ◽  
Short Time ◽  
Harbour Sludge

It is generally agreed that both the landfill option, or the civil techniques option for the final disposal of contaminated harbour sludge involves the isolation of the sludge from the environment. For short time scales, engineered barriers such as a bentonite screen, plastic sheets, pumping strategies etc. can be used. However for long time scales the effectiveness of such measures cannot be counted upon. It is thus necessary to be able to predict the long term environmenttal spread of contaminants from a mature landfill. A model is presented that considers diffusion and adsorption in the landfill site and convection and adsorption in the underlaying aquifer. From a parameter analysis starting form practical values it is shown that the adsorption behaviour and the molecular diffusion coefficient of the sludge, are the key parameters involved in the near field. The dilution effects of the far field migration patterns are also illustrated.

Interventions for Mental Health Problems in Later Life

2010 ◽  
pp. 810-837
Author(s):  
Jason M. Holland ◽  
Dolores Gallagher-Thompson
Keyword(s):  
Older Adults ◽  
Mental Health Problems ◽  
Later Life ◽  
Clinical Psychologist ◽  
Post Traumatic Stress ◽  
Future Directions ◽  
Use Of Technology ◽  
Worldwide Population ◽  
Challenges And Opportunities ◽  
Post Traumatic

Older adults are increasingly making up a larger segment of the worldwide population, which presents both challenges and opportunities for the clinical psychologist in the 21st century. In this chapter, we address some of the unique aspects of working with this population, focusing on general guidelines for tailoring interventions for older adults, specific treatments for particular problems commonly faced in later life, as well as issues of diversity and how they might impact psychotherapy with older clients. We also outline several areas in geropsychology that are in need of further investigation, namely the use of technology, post-traumatic stress, and family therapy, and offer some recommendations for future directions in this field of study.

scholarly journals A computational framework for modeling cell–matrix interactions in soft biological tissues

2021 ◽  
Author(s):  
Jonas F. Eichinger ◽  
Maximilian J. Grill ◽  
Iman Davoodi Kermani ◽  
Roland C. Aydin ◽  
Wolfgang A. Wall ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Computational Framework ◽  
Cell Matrix ◽  
Physiological Processes ◽  
Matrix Interactions ◽  
Mechanical Homeostasis ◽  
Cell Matrix Interactions ◽  
Short Time

AbstractLiving soft tissues appear to promote the development and maintenance of a preferred mechanical state within a defined tolerance around a so-called set point. This phenomenon is often referred to as mechanical homeostasis. In contradiction to the prominent role of mechanical homeostasis in various (patho)physiological processes, its underlying micromechanical mechanisms acting on the level of individual cells and fibers remain poorly understood, especially how these mechanisms on the microscale lead to what we macroscopically call mechanical homeostasis. Here, we present a novel computational framework based on the finite element method that is constructed bottom up, that is, it models key mechanobiological mechanisms such as actin cytoskeleton contraction and molecular clutch behavior of individual cells interacting with a reconstructed three-dimensional extracellular fiber matrix. The framework reproduces many experimental observations regarding mechanical homeostasis on short time scales (hours), in which the deposition and degradation of extracellular matrix can largely be neglected. This model can serve as a systematic tool for future in silico studies of the origin of the numerous still unexplained experimental observations about mechanical homeostasis.

scholarly journals A review of current state and future directions of cotton production in Ethiopia

2021 ◽  
Vol 7 (1) ◽  
pp. 1880533
Author(s):  
Tiliksew Addis ◽  
Abera Kachi ◽  
Jun Wang
Keyword(s):  
Cotton Production ◽  
Future Directions ◽  
Current State

scholarly journals Olfaction and Aging: A Review of the Current State of Research and Future Directions

i-Perception ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 204166952110203
Author(s):  
Jonas K. Olofsson ◽  
Ingrid Ekström ◽  
Maria Larsson ◽  
Steven Nordin
Keyword(s):  
Warning Signs ◽  
Future Directions ◽  
Current State ◽  
Challenging Tasks ◽  
State Of Research ◽  
To Come ◽  
Health Cognition ◽  
Olfactory Abilities ◽  
And Training

Olfaction, the sense of smell, is characterized by a notable age-dependency such that aging individuals are more likely to have poor olfactory abilities. These impairments are considered to be mostly irreversible and as having potentially profound effects on quality of life and food behavior, as well as constituting warning signs of mortality, cognitive dysfunction, and dementia. Here, we review the current state of research on aging and olfaction, focusing on five topics which we regard to be of particular relevance for the field: nutrition and health, cognition and dementia, mortality, environment and genetics, and training-based enhancement. Under each of these headlines, we provide a state-of-the-art overview and discuss gaps in our knowledge which might be filled by further research. Understanding how olfactory abilities are diminished in aging, and how they may be alleviated or recovered, involves a set of challenging tasks for researchers in the years to come.

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