scholarly journals A novel method for the preparation of biodegradable microspheres for protein drug delivery

2006 ◽  
Vol 3 (9) ◽  
pp. 573-582 ◽  
Author(s):  
R Pareta ◽  
M.J Edirisinghe
Keyword(s):  
Drug Delivery ◽  
Uv Spectroscopy ◽  
Protein Drug ◽  
Ft Ir ◽  
Novel Method ◽  
Flow Through ◽  
Protein Drug Delivery ◽  
Phosphate Buffered Saline ◽  
Structure And Activity ◽  
Ft Ir Spectroscopy

Microspheres are potential candidates for the protein drug delivery. In this work, we prepared polymer-coated starch/bovine serum albumin (BSA) microspheres using co-axial electrohydrodynamic atomization (CEHDA). First, starch solution in dimethyl sulphoxide (DMSO) was prepared and then an aqueous solution of BSA was added to it to make a starch–BSA solution. Subsequently, this solution was made to flow through the inner capillary, while the polymer, polydimethylsiloxane (PDMS), flowed through the outer capillary. On collection, filtration and subsequent drying, near-monodisperse microspheres of 5–6 μm in size were obtained. The microspheres were characterized by Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy. Cumulative BSA release was investigated by UV spectroscopy. BSA structure and activity was preserved in the microspheres and its release in 0.01 M phosphate buffered saline (PBS) was studied over a period of 8 days. There was an initial burst with 32 wt% of total BSA released in 2 h. Overall 75 wt% of BSA was released over a 7 day period.

scholarly journals Raman Spectroscopy as a Novel Method for the Characterization of Polydioxanone Medical Stents Biodegradation

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5462
Author(s):  
Jan Loskot ◽  
Daniel Jezbera ◽  
Aleš Bezrouk ◽  
Rafael Doležal ◽  
Rudolf Andrýs ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Raman Spectra ◽  
Hydrolytic Degradation ◽  
Biodegradable Stents ◽  
Ft Ir ◽  
Novel Method ◽  
First Time ◽  
Phosphate Buffered Saline ◽  
Ft Ir Spectroscopy

Polydioxanone (PPDX), as an FDA approved polymer in tissue engineering, is an important component of some promising medical devices, e.g., biodegradable stents. The hydrolytic degradation of polydioxanone stents plays a key role in the safety and efficacy of treatment. A new fast and convenient method to quantitatively evaluate the hydrolytic degradation of PPDX stent material was developed. PPDX esophageal stents were degraded in phosphate-buffered saline for 24 weeks. For the first time, the changes in Raman spectra during PPDX biodegradation have been investigated here. The level of PPDX hydrolytic degradation was determined from the Raman spectra by calculating the area under the 1732 cm−1 peak shoulder. Raman spectroscopy, unlike Fourier transform infrared (FT-IR) spectroscopy, is also sensitive enough to monitor the decrease in the dye content in the stents during the degradation. Observation by a scanning electron microscope showed gradually growing cracks, eventually leading to the stent disintegration. The material crystallinity was increasing during the first 16 weeks, suggesting preferential degradation of the amorphous phase. Our results show a new easy and reliable way to evaluate the progression of PPDX hydrolytic degradation. The proposed approach can be useful for further studies on the behavior of PPDX materials, and for clinical practice.

A Novel Oral Protein-Drug Delivery System with Bilayer Shell-Core Structure

2020 ◽  
Author(s):  
Xuan Zhang ◽  
Yanjun Tong ◽  
Xiaomei Lyu ◽  
Jianfen Ye ◽  
Ruijin Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Structure ◽  
Protein Drug ◽  
Protein Drug Delivery

A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery

2004 ◽  
Vol 96 (2) ◽  
pp. 285-300 ◽  
Author(s):  
Sung-Ching Chen ◽  
Yung-Chih Wu ◽  
Fwu-Long Mi ◽  
Yu-Hsin Lin ◽  
Lin-Chien Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Ph Sensitive ◽  
Protein Drug ◽  
Protein Drug Delivery ◽  
Ph Sensitive Hydrogel

Nanostructures for protein drug delivery

2016 ◽  
Vol 4 (2) ◽  
pp. 205-218 ◽  
Author(s):  
Juliana de Almeida Pachioni-Vasconcelos ◽  
André Moreni Lopes ◽  
Alexsandra Conceição Apolinário ◽  
Johanna Karina Valenzuela-Oses ◽  
Juliana Souza Ribeiro Costa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Nanostructured Systems ◽  
Protein Drug Delivery

Nanostructured systems, such as nanoemulsions and polymersomes, are important tools to develop safe and effective therapeutic protein preparations.

Multifunctional nanoparticles for oral protein drug delivery

2016 ◽  
Vol 120 ◽  
pp. S19
Author(s):  
Er-Yuan Chuang ◽  
Kun-Ju Lin ◽  
Fang-Yi Su ◽  
Fwu-Long Mi ◽  
Chiung-Tong Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Drug ◽  
Multifunctional Nanoparticles ◽  
Protein Drug Delivery

Synthesis and characterization of heparin conjugated Tetronic®–PCL copolymer for protein drug delivery

2007 ◽  
Vol 7 ◽  
pp. e49-e52 ◽  
Author(s):  
Jung Seok Lee ◽  
Dong Hyun Go ◽  
Jin Woo Bae ◽  
In Kwon Jung ◽  
Joon Woo Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Synthesis And Characterization ◽  
Protein Drug ◽  
Protein Drug Delivery
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