scholarly journals Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

2017 ◽  
Vol 13 (7) ◽  
pp. 20170183 ◽  
Author(s):  
Trevor J. Hamilton ◽  
Martin Tresguerres ◽  
David I. Kline
Keyword(s):  
Object Recognition ◽  
Coral Reef ◽  
Recognition Memory ◽  
Receptor Activation ◽  
Memory Formation ◽  
D1 Receptor ◽  
Complex Environments ◽  
Object Recognition Test ◽  
Novel Object ◽  
Object Recognition Memory

Object recognition memory is the ability to identify previously seen objects and is an adaptive mechanism that increases survival for many species throughout the animal kingdom. Previously believed to be possessed by only the highest order mammals, it is now becoming clear that fish are also capable of this type of memory formation. Similar to the mammalian hippocampus, the dorsolateral pallium regulates distinct memory processes and is modulated by neurotransmitters such as dopamine. Caribbean bicolour damselfish ( Stegastes partitus ) live in complex environments dominated by coral reef structures and thus likely possess many types of complex memory abilities including object recognition. This study used a novel object recognition test in which fish were first presented two identical objects, then after a retention interval of 10 min with no objects, the fish were presented with a novel object and one of the objects they had previously encountered in the first trial. We demonstrate that the dopamine D 1 -receptor agonist (SKF 38393) induces the formation of object recognition memories in these fish. Thus, our results suggest that dopamine-receptor mediated enhancement of spatial memory formation in fish represents an evolutionarily conserved mechanism in vertebrates.

Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice

2020 ◽  
Vol 14 (2) ◽  
pp. 220-233 ◽  
Author(s):  
Noritaka Nakamichi ◽  
Shunsuke Nakao ◽  
Misa Nishiyama ◽  
Yuka Takeda ◽  
Takahiro Ishimoto ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Oral Administration ◽  
Recognition Test ◽  
Hippocampal Neurons ◽  
The Novel ◽  
Object Recognition Test ◽  
Novel Object ◽  
Object Recognition Memory ◽  
Golgi Staining

Background: The enhancement of learning and memory through food-derived ingredients is of great interest to healthy individuals as well as those with diseases. Ergothioneine (ERGO) is a hydrophilic antioxidant highly contained in edible golden oyster mushrooms (Pleurotus cornucopiae var. citrinopileatus), and systemically absorbed by its specific transporter, carnitine/organic cation transporter OCTN1/SLC22A4. Objective: This study aims to examine the possible enhancement of object recognition memory by oral administration of ERGO in normal mice. Method: Novel object recognition test, spatial recognition test, LC-MS/MS, Golgi staining, neuronal culture, western blotting, immunocytochemistry, and quantitative RT-PCR were utilized. Result: After oral administration of ERGO (at a dose of 1–50 mg/kg) three times per week for two weeks in ICR mice, the novel object recognition test revealed a longer exploration time for the novel object than for the familiar object. Oral administration of ERGO also revealed a longer exploration time for the moved object in the spatial recognition test in mice fed ERGO-free diet. The discrimination index was significantly higher in the ERGO-treated group than the control in both behavioral tests. ERGO administration led to an increase in its concentration in the plasma and hippocampus. The systemic concentration reached was relevant to those found in humans after oral ERGO administration. Golgi staining revealed that ERGO administration increased the number of matured spines in the hippocampus. Exposure of cultured hippocampal neurons to ERGO elevated the expression of the synapse formation marker, synapsin I. This elevation of synapsin I was inhibited by the tropomyosin receptor kinase inhibitor, K252a. Treatment with ERGO also increased the expression of neurotrophin-3 and -5, and phosphorylated mammalian target of rapamycin in hippocampal neurons. Conclusion: Oral intake of ERGO which provides its plasma concentration achievable in humans may enhance object recognition memory, and this enhancement effect could occur, at least in part, through the promotion of neuronal maturation in the hippocampus.

scholarly journals GABA Affects Novel Object Recognition Memory and Working Memory in Rats

2013 ◽  
Vol 59 (2) ◽  
pp. 152-157 ◽  
Author(s):  
Panicha THANAPREEDAWAT ◽  
Hiroki KOBAYASHI ◽  
Naoto INUI ◽  
Kazuhiro SAKAMOTO ◽  
Mujo KIM ◽  
...  
Keyword(s):  
Working Memory ◽  
Object Recognition ◽  
Recognition Memory ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Object Recognition Memory

scholarly journals Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice

2020 ◽  
Vol 95 ◽  
pp. 154-160
Author(s):  
Saahj P. Gosrani ◽  
Hannah M. Jester ◽  
Xueyan Zhou ◽  
Alexey G. Ryazanov ◽  
Tao Ma
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Aged Mice ◽  
Object Recognition Memory ◽  
Eef2 Kinase

scholarly journals Transgenic miR132 Alters Neuronal Spine Density and Impairs Novel Object Recognition Memory

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e15497 ◽  
Author(s):  
Katelin F. Hansen ◽  
Kensuke Sakamoto ◽  
Gary A. Wayman ◽  
Soren Impey ◽  
Karl Obrietan
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Novel Object Recognition ◽  
Spine Density ◽  
Novel Object ◽  
Object Recognition Memory
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