The H1-Receptor Antagonist Cetirizine Protects Partially Against Cytokine- and Hydrogen Peroxide–Induced β-TC6 Cell Death In Vitro

Pancreas ◽  
2014 ◽  
Vol 43 (4) ◽  
pp. 624-629 ◽  
Author(s):  
Ebrahim Anvari ◽  
Rikard G. Fred ◽  
Nils Welsh
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Receptor Antagonist ◽  
H1 Receptor ◽  
H1 Receptor Antagonist

scholarly journals In vitro H1-receptor antagonist activity of methanolic extract of tuber of Stephania glabra

2010 ◽  
Vol 5 (2) ◽  
Author(s):  
Nisar Ahmad Khan ◽  
Dinesh Kumar ◽  
Zulfiqar Ali Bhat ◽  
Vijender Kumar ◽  
Navneet Nagpal ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Methanolic Extract ◽  
H1 Receptor ◽  
Antagonist Activity ◽  
H1 Receptor Antagonist

H1-receptor-mediated excitation and facilitation of the heat response by histamine in canine visceral polymodal receptors studied in vitro

1996 ◽  
Vol 76 (3) ◽  
pp. 1396-1404 ◽  
Author(s):  
H. Koda ◽  
M. Minagawa ◽  
L. Si-Hong ◽  
K. Mizumura ◽  
T. Kumazawa
Keyword(s):  
Receptor Antagonist ◽  
Discharge Rate ◽  
Facilitatory Effect ◽  
Receptor Subtype ◽  
H1 Receptor ◽  
H2 Receptor Antagonist ◽  
Histamine Concentration ◽  
Heat Response ◽  
H1 Receptor Antagonist

1. We examined excitation and the facilitatory effect on the heat responses induced by histamine in visceral polymodal receptors with the use of the canine testis-spermatic nerve preparation in vitro. 2. The proportion of units that showed excitation (> 10 impulses 1 min after application of histamine was initiated) increased roughly with higher concentrations of histamine: 7% at 1 microM, 26% at 10 microM, 79% at 100 microM, and 61% at 1,000 microM. The discharge rate also increased with the concentration. 3. Histamine (100 and 1,000 microM) responses > 0.5 imp/s were observed only in units with conduction velocities (CVs) of < or = 10 m/s, but not in those with CVs faster than 10 m/s. On average, histamine-induced discharges were significantly greater in units with CVs of < or = 10 m/s at all concentrations > or = 10 microM. Thus units studied in this experiment were empirically divided into slow-CV (< or = m/s) and fast-CV (> 10 m/s) groups. 4. Histamine significantly facilitated the heat responses of the slow-CV group from 10 microM, and also facilitated the fast-CV group from 100 microM. This sensitizing effect was observed irrespective of the precedent histamine-induced excitation. The magnitude of sensitization tended to increase with an increase in histamine concentration. 5. For studying the histamine receptor subtype involved in excitation and facilitation, we used D-chlorpheniramine maleate (5 microM) (an H1 receptor antagonist), famotidine (20 microM) (an H2 receptor antagonist), and thioperamide maleate (20 microM) (an H3 receptor antagonist). The magnitude of histamine-induced excitation of the slow-CV group was significantly suppressed by the H1 receptor antagonist but not by other antagonists. 6. The facilitatory effect of histamine on the heat response was also suppressed by the H1 receptor antagonist in both slow- and fast-CV groups. 7. These results strongly suggested that both excitation and facilitation of the heat response induced by histamine are mediated through the H1 receptor.

scholarly journals Effect of Epinastine Hydrochloride, a Second-generation Histamine H1-receptor Antagonist, on Sensory Neurons in vitro

2005 ◽  
Vol 54 (4) ◽  
pp. 565-572 ◽  
Author(s):  
Masahiko Toyoda ◽  
Motokazu Nakamura ◽  
Kaori Nakada ◽  
Maki Iida ◽  
Masaki Nakamura ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Sensory Neurons ◽  
Second Generation ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
H1 Receptor Antagonist

Asymmetric synthesis of H1 receptor antagonist (R,R)-clemastine

2015 ◽  
Vol 38 (12) ◽  
pp. 2131-2136 ◽  
Author(s):  
Sun Young Lee ◽  
Jung Wha Jung ◽  
Tae-Hyun Kim ◽  
Hee-Doo Kim
Keyword(s):  
Receptor Antagonist ◽  
Asymmetric Synthesis ◽  
H1 Receptor ◽  
H1 Receptor Antagonist
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