BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression

2013 ◽  
Vol 23 (6) ◽  
pp. 301-313 ◽  
Author(s):  
Greer M. Murphy ◽  
Jane E. Sarginson ◽  
Heather S. Ryan ◽  
Ruth O’Hara ◽  
Alan F. Schatzberg ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Genetic Variants ◽  
Antidepressant Treatment ◽  
Geriatric Depression

scholarly journals Whole-genome sequencing reveals KRTAP1-1 as a novel genetic variant associated with antidepressant treatment outcomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jong-Ho Park ◽  
Shinn-Won Lim ◽  
Woojae Myung ◽  
Inho Park ◽  
Hyeok-Jae Jang ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Treatment Outcomes ◽  
Genetic Markers ◽  
Genome Sequencing ◽  
Genetic Variants ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Remission Rate ◽  
Antidepressant Treatment ◽  
Whole Genome ◽  
Loss Of Function

AbstractAchieving remission following initial antidepressant therapy in patients with major depressive disorder (MDD) is an important clinical result. Making predictions based on genetic markers holds promise for improving the remission rate. However, genetic variants found in previous genetic studies do not provide robust evidence to aid pharmacogenetic decision-making in clinical settings. Thus, the objective of this study was to perform whole-genome sequencing (WGS) using genomic DNA to identify genetic variants associated with the treatment outcomes of selective serotonin reuptake inhibitors (SSRIs). We performed WGS on 100 patients with MDD who were treated with escitalopram (discovery set: 36 remitted and 64 non-remitted). The findings were applied to an additional 553 patients with MDD who were treated with SSRIs (replication set: 185 remitted and 368 non-remitted). A novel loss-of-function variant (rs3213755) in keratin-associated protein 1–1 (KRTAP1-1) was identified in this study. This rs3213755 variant was significantly associated with remission following antidepressant treatment (p = 0.0184, OR 3.09, 95% confidence interval [CI] 1.22–7.80 in the discovery set; p = 0.00269, OR 1.75, 95% CI 1.22–2.53 in the replication set). Moreover, the expression level of KRTAP1-1 in surgically resected human temporal lobe samples was significantly associated with the rs3213755 genotype. WGS studies on a larger sample size in various ethnic groups are needed to investigate genetic markers useful in the pharmacogenetic prediction of remission following antidepressant treatment.

Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: The CRESCEND study

2011 ◽  
Vol 189 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Su-Jin Yang ◽  
Sun-Young Kim ◽  
Robert Stewart ◽  
Jae-Min Kim ◽  
Il-Seon Shin ◽  
...  
Keyword(s):  
Gender Differences ◽  
Treatment Outcomes ◽  
Secondary Care ◽  
Antidepressant Treatment

scholarly journals Geriatric Depression and Inappropriate Medication: Benefits of Interprofessional Team Cooperation in Nursing Homes

2021 ◽  
Vol 18 (23) ◽  
pp. 12438
Author(s):  
Hana Vankova ◽  
Iva Holmerova ◽  
Ladislav Volicer
Keyword(s):  
Depressive Symptoms ◽  
Nursing Homes ◽  
Antidepressant Treatment ◽  
Inappropriate Medication ◽  
Depression Scale ◽  
Nursing Home Residents ◽  
Geriatric Depression ◽  
Cross Sectional ◽  
Interprofessional Team ◽  
Permanent Resident

An investigation of inappropriate medication use in treatment of depressivity in institutionalized older adults, based on a nurse-led evaluation of functional status and depressive symptoms in nursing home residents. Methods: A cross-sectional multicenter study was performed using records from 1087 residents cared for in fifteen nursing homes (NHs) in the Czech Republic. Inclusion criteria were being a permanent resident of one of the facilities, being 60 years of age or older, having a Geriatric Depression Scale score of 6 or more, and having a Mini Mental State examination score 10 or more. The final sample for analysis included 317 depressed NH residents. Results: 52 percent of NH residents with depressivity had no antidepressant treatment. Benzodiazepines were the only medication in 16 percent of depressed residents, and were added to antidepressant treatment in 18 percent of residents. Benzodiazepine users had significantly higher GDS scores compared to non-users (p = 0.007). Conclusion: More than half of depressed NH residents remained without antidepressant treatment. Residents inappropriately treated with benzodiazepines were more depressed than residents treated with antidepressants only, or even not treated at all. Cooperation of the interprofessional team in the screening of depressive symptoms has the potential to improve the quality of care.

Influence of ABCB1 genetic variants in breast cancer treatment outcomes

2013 ◽  
Vol 37 (5) ◽  
pp. 754-761 ◽  
Author(s):  
P. Chaturvedi ◽  
S. Tulsyan ◽  
G. Agarwal ◽  
P. Lal ◽  
S. Agarwal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Treatment Outcomes ◽  
Genetic Variants ◽  
Breast Cancer Treatment

Abstract 2032: Germline genetic variants in GATA3 and breast cancer treatment outcomes in SWOG 8897 trial

2016 ◽  
Author(s):  
Victoria L. Larsen ◽  
William E. Barlow ◽  
Jun J. Yang ◽  
Qianqian Zhu ◽  
Laura F. Hutchins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Treatment Outcomes ◽  
Genetic Variants ◽  
Breast Cancer Treatment
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