Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy

2011 ◽  
Vol 21 (5) ◽  
pp. 289-296 ◽  
Author(s):  
Alexandra Doehring ◽  
Wolf Peter Hofmann ◽  
Christina Schlecker ◽  
Stefan Zeuzem ◽  
Christoph Sarrazin ◽  
...  
Keyword(s):  
Nucleoside Transporters

Investigating the role of nucleoside transporters in the resistance of colorectal cancer to 5-fluorouracil therapy

2012 ◽  
Vol 71 (3) ◽  
pp. 817-823 ◽  
Author(s):  
Lee Cheng Phua ◽  
Mainak Mal ◽  
Poh Koon Koh ◽  
Peh Yean Cheah ◽  
Eric Chun Yong Chan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Nucleoside Transporters

Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine

2012 ◽  
Vol 31 (3) ◽  
pp. 236-255 ◽  
Author(s):  
Vijaya L. Damaraju ◽  
Delores Mowles ◽  
Sylvia Yao ◽  
Amy Ng ◽  
James D. Young ◽  
...  
Keyword(s):  
Nucleoside Transporters

scholarly journals Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

Oncogene ◽  
2003 ◽  
Vol 22 (47) ◽  
pp. 7524-7536 ◽  
Author(s):  
Vijaya L Damaraju ◽  
Sambasivarao Damaraju ◽  
James D Young ◽  
Stephen A Baldwin ◽  
John Mackey ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Cancer Chemotherapy ◽  
Nucleoside Transporters

The Role of Human Nucleoside Transporters in Cellular Uptake of 4′-Thio-β-d-arabinofuranosylcytosine and β-d-Arabinosylcytosine

2006 ◽  
Vol 70 (1) ◽  
pp. 303-310 ◽  
Author(s):  
Marilyn L. Clarke ◽  
Vijaya L. Damaraju ◽  
Jing Zhang ◽  
Delores Mowles ◽  
Tracey Tackaberry ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Nucleoside Transporters

scholarly journals Role of human nucleoside transporters in pancreatic cancer and chemoresistance

2021 ◽  
Vol 27 (40) ◽  
pp. 6844-6860
Author(s):  
Carly Jade Carter ◽  
Ahmed H Mekkawy ◽  
David L Morris
Keyword(s):  
Pancreatic Cancer ◽  
Nucleoside Transporters

Role of Human Nucleoside Transporters in the Cellular Uptake of Two Inhibitors of IMP Dehydrogenase, Tiazofurin and Benzamide Riboside

2004 ◽  
Vol 67 (1) ◽  
pp. 273-279 ◽  
Author(s):  
Vijaya L. Damaraju ◽  
Frank Visser ◽  
Jing Zhang ◽  
Delores Mowles ◽  
Amy M. L. Ng ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Nucleoside Transporters ◽  
Imp Dehydrogenase ◽  
Benzamide Riboside

Role of astrocytic nucleoside transporters on oxidative stress

2010 ◽  
Vol 68 ◽  
pp. e126-e127
Author(s):  
Koh-ichi Tanaka ◽  
Nobue Kitanaka ◽  
Junichi Kitanaka ◽  
Tomoaki Sato ◽  
Takashige Nishikawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nucleoside Transporters

Physiology of Nucleoside Transporters: Back to the Future. . . .

Physiology ◽  
2008 ◽  
Vol 23 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Jennifer B. Rose ◽  
Imogen R. Coe
Keyword(s):  
Viral Infections ◽  
Drug Efficacy ◽  
Structure And Function ◽  
Nucleoside Transporters ◽  
Integral Membrane Proteins ◽  
Future Research ◽  
The Everyday ◽  
And Function ◽  
The Relationship

Nucleoside transporters (NTs) are integral membrane proteins responsible for mediating and facilitating the flux of nucleosides and nucleobases across cellular membranes. NTs are also responsible for the uptake of nucleoside analog drugs used in the treatment of cancer and viral infections, and they are the target of certain compounds used in the treatment of some types of cardiovascular disease. The important role of NTs as drug transporters and therapeutic targets has necessarily led to intense interest into their structure and function and the relationship between these proteins and drug efficacy. In contrast, we still know relatively little about the fundamental physiology of NTs. In this review, we discuss various aspects of the physiology of NTs in mammalian systems, particularly noting tissues and cells where there has been little recent research. Our central thesis is reference back to some of the older literature, combined with current findings, will provide direction for future research into NT physiology that will lead to a fuller understanding of the role of these intriguing proteins in the everyday lives of cells, tissues, organs, and whole animals.

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