ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment

2010 ◽  
pp. 1 ◽  
Author(s):  
Keh-Ming Lin ◽  
Yen-Feng Chiu ◽  
I-Ju Tsai ◽  
Chia-Hui Chen ◽  
Winston W. Shen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gene Polymorphisms ◽  
Major Depressive ◽  
Abcb1 Gene

scholarly journals Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population

2014 ◽  
Vol 157 ◽  
pp. 100-103 ◽  
Author(s):  
Ping Hua ◽  
Weiguo Liu ◽  
Donghui Chen ◽  
Yanyan Zhao ◽  
Ling Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Major Depressive

scholarly journals Association of EGF, IGFBP-3 and TP53 Gene Polymorphisms with Major Depressive Disorder in Slovak Population

2016 ◽  
Vol 24 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Silvia Mahmood ◽  
Andrea Evinová ◽  
Mária Škereňová ◽  
Igor Ondrejka ◽  
Ján Lehotský
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gene Polymorphisms ◽  
Tp53 Gene ◽  
Major Depressive ◽  
Slovak Population ◽  
Igfbp 3

Associations of Tumor Necrosis Factor–α G-308A (rs1800629) Gene Polymorphisms with Major Depressive Disorder

2021 ◽  
Vol 19 (7) ◽  
pp. 133-136
Author(s):  
Aamal Muhsen Kadhum ◽  
Bayader M. Abd Al–Kadim ◽  
Thanaa Chasib Kareem ◽  
Ali Ahmed Nayyef ◽  
Mona N. Al-Terehi
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Control Group ◽  
Major Depressive ◽  
Allele Distribution ◽  
Tnf Α ◽  
Necrosis Factor

Pro-inflammatory cytokine polymorphisms like Tumor Necrosis Factor- (TNF), has been found associated to severe depressive disorder (MDD). The Pro-inflammatory cytokines tumor necrosis factor (TNF-α) G-308A (rs1800629) have been discovered to have an important role in the pathophysiology of depressive disorders and the mechanism of antidepressant treatment. The present study aims to study TNF-α gene polymorphisms in Major depressive disorder using allele specific PCR. The results show that family history are non- significant different between patients and control group (0.6346) and also there was non- significant different in BMI (0.3417), The genotyping data show tow alleles and three genotyping (AG, GG, AA) the statically analysis show non-significant differences between patients and controls groups (0.095, 0.800) for GG, AA and GA respectively with more frequent of GA in patients than control group, the G allele was less frequent in patient than control while A allele was more frequent in patients than control group in significant differences (0.0001). It can be concluded that TNF genotyping didn’t impact in the Major depressive disorder but the allele distribution may have potential role in MDD patients.

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