scholarly journals Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca 2+ release via M 3 receptor activation

2020 ◽  
Vol 34 (8) ◽  
pp. 10073-10095
Author(s):  
Bernard T. Drumm ◽  
Benjamin E. Rembetski ◽  
Kaitlin Huynh ◽  
Aqeel Nizar ◽  
Salah A. Baker ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Receptor Activation ◽  
Interstitial Cells ◽  
Mouse Colon ◽  
Cells Of Cajal

scholarly journals Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon

2014 ◽  
Vol 18 (4) ◽  
pp. 341 ◽  
Author(s):  
Han-Yi Jiao ◽  
Dong Hyun Kim ◽  
Jung Suk Ki ◽  
Kwon Ho Ryu ◽  
Seok Choi ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Pacemaker Activity ◽  
Mouse Colon ◽  
Cells Of Cajal

Plasticity of interstitial cells of Cajal: a study of mouse colon

2006 ◽  
Vol 325 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Maria-Simonetta Faussone-Pellegrini ◽  
Maria-Giuliana Vannucchi ◽  
Oren Ledder ◽  
Tian-Ying Huang ◽  
Menachem Hanani
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Mouse Colon ◽  
Cells Of Cajal

Functional effects of β3-adrenoceptor on pacemaker activity in interstitial cells of Cajal from the mouse colon

2015 ◽  
Vol 754 ◽  
pp. 32-40 ◽  
Author(s):  
Mei Jin Wu ◽  
Dong Hoon Shin ◽  
Man Yoo Kim ◽  
Chan Guk Park ◽  
Young Dae Kim ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Pacemaker Activity ◽  
Mouse Colon ◽  
Cells Of Cajal

scholarly journals Pacemaker function and neural responsiveness of subserosal interstitial cells of Cajal in the mouse colon

2020 ◽  
Vol 598 (4) ◽  
pp. 651-681 ◽  
Author(s):  
Bernard T. Drumm ◽  
Benjamin E. Rembetski ◽  
Katelyn Messersmith ◽  
Marena S. Manierka ◽  
Salah A. Baker ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Mouse Colon ◽  
Pacemaker Function ◽  
Cells Of Cajal

PKC-ϵ translocation in enteric neurons and interstitial cells of Cajal in response to muscarinic stimulation

2003 ◽  
Vol 285 (3) ◽  
pp. G593-G601 ◽  
Author(s):  
Xuan-Yu Wang ◽  
Sean M. Ward ◽  
William T. Gerthoffer ◽  
Kenton M. Sanders
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Cholinergic Neurons ◽  
Receptor Activation ◽  
Interstitial Cells ◽  
Enteric Neurons ◽  
Peripheral Compartment ◽  
Western Blots ◽  
Excitatory Neurotransmitter ◽  
Myenteric Neurons ◽  
Cells Of Cajal

Interstitial cells of Cajal in the deep muscular plexus (ICC-DMP) of the small intestine express excitatory neurotransmitter receptors. We tested whether ICC-DMP are functionally innervated by cholinergic neurons in the murine intestine. Muscles were stimulated by intrinsic nerves and ACh and processed for immunohistochemistry to determine these effects on PKC-ϵ activation. Under control conditions, PKC-ϵ-like immunoreactivy (PKC-ϵ-LI) was only observed in myenteric neurons within the tunica muscularis. Electrical field stimulation or ACh caused translocation of neural PKC-ϵ-LI from the cytosol to a peripheral compartment. After stimulation, PKC-ϵ-LI was found in spindle-shaped cells in the DMP. These cells were identified as ICC-DMP by Kit-LI and vimentin-LI. PKC-ϵ-LI in ICC-DMP and translocation of PKCϵ-LI in neurons were blocked by tetrodotoxin or atropine, suggesting that these responses were due to activation of muscarinic receptors. Western blots also confirmed translocation of PKC-ϵ-LI. In conclusion, PKC-ϵ translocation is linked to muscarinic receptor activation in ICC-DMP and a subpopulation of myenteric neurons. These studies demonstrate that ICC-DMP are functionally innervated by excitatory motoneurons.

Distribution and ultrastructure of interstitial cells of Cajal in the mouse colon, using antibodies to Kit and Kit W-lacZ mice

2000 ◽  
Vol 302 (2) ◽  
pp. 155-170 ◽  
Author(s):  
Jean-Marie Vanderwinden ◽  
Jüri J. Rumessen ◽  
Florence Bernex ◽  
Serge N. Schiffmann ◽  
Jean-Jacques Panthier
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Mouse Colon ◽  
Cells Of Cajal
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