scholarly journals LNX1 contributes to tumor growth by down-regulating p53 stability

2019 ◽  
Vol 33 (12) ◽  
pp. 13216-13227
Author(s):  
Rackhyun Park ◽  
Hyunju Kim ◽  
Minsu Jang ◽  
Daum Jo ◽  
Yea-In Park ◽  
...  
Keyword(s):  
Tumor Growth ◽  
P53 Stability

scholarly journals Two Distinct Activities Contribute to the Oncogenic Potential of the Adenovirus Type 5 E4orf6 Protein

2000 ◽  
Vol 74 (11) ◽  
pp. 5168-5181 ◽  
Author(s):  
Michael Nevels ◽  
Susanne Rubenwolf ◽  
Thilo Spruss ◽  
Hans Wolf ◽  
Thomas Dobner
Keyword(s):  
Tumor Suppressor ◽  
Tumor Growth ◽  
Viral Protein ◽  
Alpha Helix ◽  
Adenovirus Type ◽  
Viral Oncoprotein ◽  
Oncogenic Potential ◽  
P53 Stability ◽  
Carboxy Terminal ◽  
Adenovirus Type 5

ABSTRACT Previous studies have shown that the adenovirus type 5 (Ad5) E4orf6 gene product displays features of a viral oncoprotein. It initiates focal transformation of primary rat cells in cooperation with Ad5 E1 genes and confers multiple additional transformed properties on E1-expressing cells, including profound morphological alterations and dramatically accelerated tumor growth in nude mice. It has been reported that E4orf6 binds to p53 and, in the presence of the Ad5 E1B-55kDa protein, antagonizes p53 stability by targeting the tumor suppressor protein for active degradation. In the present study, we performed a comprehensive mutant analysis to assign transforming functions of E4orf6 to distinct regions within the viral polypeptide and to analyze a possible correlation between E4orf6-dependent p53 degradation and oncogenesis. Our results show that p53 destabilization maps to multiple regions within both amino- and carboxy-terminal parts of the viral protein and widely cosegregates with E4orf6-dependent acceleration of tumor growth, indicating that both effects are related. In contrast, promotion of focus formation and morphological transformation require only a carboxy-terminal segment of the E4 protein. Thus, these effects are completely independent of p53 stability, but may involve other interactions with the tumor suppressor. Our results demonstrate that at least two distinct activities contribute to the oncogenic potential of Ad5 E4orf6. Although genetically separable, both activities are largely mediated through a novel highly conserved, cysteine-rich motif and a recently described arginine-faced amphipathic alpha helix, which resides within a carboxy-terminal “oncodomain” of the viral protein.

655: EBAG9/RCAS1 Expression Enhances Tumor Growth in Renal Cell Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 178-179
Author(s):  
Tetsuo Ogushi ◽  
Takahashi Satoru ◽  
Takumi Takeuchi ◽  
Tetsuya Fujimura ◽  
Tomohiko Urano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell

815: Human Kallikrein 2 (HK2) Inhibitors Suppress Tumor Growth of Prostate Cancer Xenografts in Nude Mice

2006 ◽  
Vol 175 (4S) ◽  
pp. 263-263
Author(s):  
Christoph Kündig ◽  
Sylvain M. Cloutier ◽  
Steve Aellen ◽  
Loyse M. Felber ◽  
Jair R. Chagas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Nude Mice ◽  
Human Kallikrein 2 ◽  
Kallikrein 2

442: Stromal Hedgehog Pathway Activity Accelerates Prostate Tumor Growth

2006 ◽  
Vol 175 (4S) ◽  
pp. 143-143
Author(s):  
Aubie Shaw ◽  
Jerry Gipp ◽  
Wade Bushman
Keyword(s):  
Tumor Growth ◽  
Prostate Tumor ◽  
Hedgehog Pathway ◽  
Pathway Activity

Role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
N Azoitei ◽  
GV Pusapati ◽  
A Kleger ◽  
C Brunner ◽  
F Genze ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Pancreatic Tumor
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