scholarly journals Long‐term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease

2019 ◽  
Vol 33 (9) ◽  
pp. 9871-9884 ◽  
Author(s):  
Melissa J. Alldred ◽  
Helen M. Chao ◽  
Sang Han Lee ◽  
Judah Beilin ◽  
Brian E. Powers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Mouse Model ◽  
Pyramidal Neuron ◽  
Long Term Effects ◽  
Ts65dn Mouse ◽  
Ca1 Pyramidal Neuron

scholarly journals CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation

Hippocampus ◽  
2018 ◽  
Vol 28 (4) ◽  
pp. 251-268 ◽  
Author(s):  
Melissa J. Alldred ◽  
Helen M. Chao ◽  
Sang Han Lee ◽  
Judah Beilin ◽  
Brian E. Powers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Murine Model ◽  
Pyramidal Neuron ◽  
Ca1 Pyramidal Neuron

Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer’s Disease

2020 ◽  
pp. 1-16
Author(s):  
Margaret Ryan ◽  
Valerie T.Y. Tan ◽  
Nasya Thompson ◽  
Diane Guévremont ◽  
Bruce G. Mockett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Integrated Analysis ◽  
Empty Vector ◽  
Mouse Transcriptome

Background: Secreted amyloid precursor protein-alpha (sAPPα) can enhance memory and is neurotrophic and neuroprotective across a range of disease-associated insults, including amyloid-β toxicity. In a significant step toward validating sAPPα as a therapeutic for Alzheimer’s disease (AD), we demonstrated that long-term overexpression of human sAPPα (for 8 months) in a mouse model of amyloidosis (APP/PS1) could prevent the behavioral and electrophysiological deficits that develop in these mice. Objective: To explore the underlying molecular mechanisms responsible for the significant physiological and behavioral improvements observed in sAPPα-treated APP/PS1 mice. Methods: We assessed the long-term effects on the hippocampal transcriptome following continuous lentiviral delivery of sAPPα or empty-vector to male APP/PS1 mice and wild-type controls using Affymetrix Mouse Transcriptome Assays. Data analysis was carried out within the Affymetrix Transcriptome Analysis Console and an integrated analysis of the resulting transcriptomic data was performed with Ingenuity Pathway analysis (IPA). Results: Mouse transcriptome assays revealed expected AD-associated gene expression changes in empty-vector APP/PS1 mice, providing validation of the assays used for the analysis. By contrast, there were specific sAPPα-associated gene expression profiles which included increases in key neuroprotective genes such as Decorin, betaine-GABA transporter, and protocadherin beta-5, subsequently validated by qRT-PCR. An integrated biological pathways analysis highlighted regulation of GABA receptor signaling, cell survival, and inflammatory responses. Furthermore, upstream gene regulatory analysis implicated sAPPα activation of Interleukin-4, which can counteract inflammatory changes in AD. Conclusion: This study identified key molecular processes that likely underpin the long-term neuroprotective and therapeutic effects of increasing sAPPα levels in vivo

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

Neuroscience ◽  
2016 ◽  
Vol 333 ◽  
pp. 277-301 ◽  
Author(s):  
Fiorenza Stagni ◽  
Andrea Giacomini ◽  
Marco Emili ◽  
Stefania Trazzi ◽  
Sandra Guidi ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Long Term Effects ◽  
Ts65dn Mouse ◽  
Short And Long Term ◽  
Hippocampal Development

Impaired Sustained Attention and Error-Induced Stereotypy in the Aged Ts65Dn Mouse: A Mouse Model of Down Syndrome and Alzheimer's Disease.

2004 ◽  
Vol 118 (6) ◽  
pp. 1196-1205 ◽  
Author(s):  
Lori L. Driscoll ◽  
Jenna C. Carroll ◽  
Jisook Moon ◽  
Linda S. Crnic ◽  
David A. Levitsky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Mouse Model ◽  
Sustained Attention ◽  
Ts65dn Mouse

scholarly journals Sex Differences in the Cholinergic Basal Forebrain in the Ts65Dn Mouse Model of Down Syndrome and Alzheimer's Disease

2013 ◽  
Vol 24 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Christy M. Kelley ◽  
Brian E. Powers ◽  
Ramon Velazquez ◽  
Jessica A. Ash ◽  
Stephen D. Ginsberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Differences ◽  
Down Syndrome ◽  
Mouse Model ◽  
Basal Forebrain ◽  
Ts65dn Mouse ◽  
Cholinergic Basal Forebrain

scholarly journals Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease

2019 ◽  
Vol 72 (1) ◽  
pp. 161-180 ◽  
Author(s):  
Marlena Zyśk ◽  
Fredrik Clausen ◽  
Ximena Aguilar ◽  
Dag Sehlin ◽  
Stina Syvänen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Long Term Effects ◽  
Model Of Alzheimer’S Disease
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