scholarly journals Autophagy and mitochondrial biogenesis impairment contribute to age‐dependent liver injury in experimental sepsis: dysregulation of AMP‐activated protein kinase pathway

2018 ◽  
Vol 32 (2) ◽  
pp. 728-741 ◽  
Author(s):  
Yu Inata ◽  
Satoshi Kikuchi ◽  
Ravi S. Samraj ◽  
Paul W. Hake ◽  
Michael O'Connor ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Liver Injury ◽  
Mitochondrial Biogenesis ◽  
Experimental Sepsis ◽  
Age Dependent ◽  
Amp Activated Protein Kinase ◽  
Kinase Pathway

scholarly journals Regulation of glycogen synthesis by the laforin–malin complex is modulated by the AMP-activated protein kinase pathway

2007 ◽  
Vol 17 (5) ◽  
pp. 667-678 ◽  
Author(s):  
Maria Carmen Solaz-Fuster ◽  
José Vicente Gimeno-Alcañiz ◽  
Susana Ros ◽  
Maria Elena Fernandez-Sanchez ◽  
Belen Garcia-Fojeda ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Glycogen Synthesis ◽  
Amp Activated Protein Kinase ◽  
Kinase Pathway

Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery

2019 ◽  
Vol 56 (7) ◽  
pp. 472-492 ◽  
Author(s):  
Saeideh Momtaz ◽  
Armin Salek-Maghsoudi ◽  
Amir Hossein Abdolghaffari ◽  
Eghbal Jasemi ◽  
Shamsali Rezazadeh ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Kinase ◽  
Amp Activated Protein Kinase ◽  
Kinase Pathway

scholarly journals Effect of Quercetin Treatment on Mitochondrial Biogenesis and Exercise-Induced AMP-Activated Protein Kinase Activation in Rat Skeletal Muscle

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 729 ◽  
Author(s):  
Keiichi Koshinaka ◽  
Asuka Honda ◽  
Hiroyuki Masuda ◽  
Akiko Sato
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Endurance Exercise ◽  
Mitochondrial Biogenesis ◽  
Exercise Performance ◽  
Term Therapy ◽  
High Dose ◽  
Rat Skeletal Muscle ◽  
Amp Activated Protein Kinase ◽  
Quercetin Treatment

The purpose of this study was to evaluate the effect of chronic quercetin treatment on mitochondrial biogenesis, endurance exercise performance and activation levels of AMP-activated protein kinase (AMPK) in rat skeletal muscle. Rats were assigned to a control or quercetin group and were fed for 7 days. Rats treated with quercetin showed no changes in the protein levels of citrate synthase or cytochrome C oxidase IV or those of sirtuin 1, peroxisome proliferator-activated receptor gamma coactivator-1α or phosphorylated AMPK. After endurance swimming exercise, quercetin-treated rats demonstrated no differences in blood and muscle lactate levels or glycogen utilization speed compared to control rats. These results indicate that quercetin treatment does not stimulate mitochondrial biogenesis in skeletal muscle and does not influence metabolism in a way that might enhance endurance exercise capacity. On the other hand, the AMPK phosphorylation level immediately after exercise was significantly lower in quercetin-treated muscles, suggesting that quercetin treatment might provide a disadvantage to muscle adaptation when administered with exercise training. The molecular results of this study indicate that quercetin treatment may not be advantageous for improving endurance exercise performance, at least after high-dose and short-term therapy.

Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase

2015 ◽  
Vol 27 (9) ◽  
pp. 1873-1881 ◽  
Author(s):  
Parkyong Song ◽  
Yonghoon Kwon ◽  
Kyungmoo Yea ◽  
Hyo-Youl Moon ◽  
Jong Hyuk Yoon ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitochondrial Biogenesis ◽  
Apolipoprotein A1 ◽  
Amp Activated Protein Kinase

Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats

Pharmacology ◽  
2018 ◽  
Vol 102 (3-4) ◽  
pp. 117-125 ◽  
Author(s):  
Luyao Wang ◽  
Haojie Shan ◽  
Bin Wang ◽  
Nan Wang ◽  
Zubin Zhou ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Signaling Pathway ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Function ◽  
Cartilage Damage ◽  
Joint Disease ◽  
Mitochondrial Dysfunctions ◽  
Compound C ◽  
Amp Activated Protein Kinase ◽  
And Cartilage

Background/Aims: Osteoarthritis is the most common degenerative joint disease and causes major pain and disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes was associated with osteoarthritis. Puerarin has multiple effects including restoring mitochondrial function. In this study, the potential effects of puerarin on osteoarthritis and osteoarthritis associated mitochondrial dysfunctions were evaluated. Methods: Osteoarthritis rats were treated with puerarin and the severity of osteoarthritis and cartilage damages was evaluated. The mitochondrial biogenesis and functions were analyzed by measuring related proteins expression, mitochondrial DNA content, ATP production, and oxygen consumption. The dependence of AMP-activated protein kinase (AMPK) pathway on puerarin-regulated mitochondrial function was analyzed by applying AMPK inhibitor Compound C. Results: Puerarin treatment alleviated mechanical hyperalgesia and cartilage damage in osteoarthritis rats. Puerarin increased mitochondrial biogenesis and attenuated mitochondrial dysfunctions in osteoarthritis rats. AMPK inhibitor Compound C abolished puerarin’s effects. Conclusion: Puerarin attenuates osteoarthritis by upregulating the AMPK/proliferator-activated receptor-γ coactivator signaling pathway in osteoarthritis rats.

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