scholarly journals Adaptable interaction between aquaporin‐1 and band 3 reveals a potential role of water channel in blood CO 2 transport

2017 ◽  
Vol 31 (10) ◽  
pp. 4256-4264 ◽  
Author(s):  
Kate Hsu ◽  
Ting‐Ying Lee ◽  
Ammasi Periasamy ◽  
Fu‐Jen Kao ◽  
Li‐Tzu Li ◽  
...  
Keyword(s):  
Potential Role ◽  
Water Channel ◽  
Band 3 ◽  
Aquaporin 1

scholarly journals Regulation of Macrophage Motility by the Water Channel Aquaporin-1: Crucial Role of M0/M2 Phenotype Switch

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117398 ◽  
Author(s):  
Donatienne Tyteca ◽  
Tomoya Nishino ◽  
Huguette Debaix ◽  
Patrick Van Der Smissen ◽  
Francisca N'Kuli ◽  
...  
Keyword(s):  
Crucial Role ◽  
Water Channel ◽  
Aquaporin 1 ◽  
Phenotype Switch ◽  
M2 Phenotype

The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells

2018 ◽  
Vol 233 (6) ◽  
pp. 4919-4925 ◽  
Author(s):  
Ji Li ◽  
Mincheng Zhang ◽  
Yong Mao ◽  
Yimao Li ◽  
Xiaoxia Zhang ◽  
...  
Keyword(s):  
Potential Role ◽  
Aristolochic Acid ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Aquaporin 1 ◽  
Aristolochic Acid I

scholarly journals AQP1-Containing Exosomes in Peritoneal Dialysis Effluent As Biomarker of Dialysis Efficiency

Cells ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 330 ◽  
Author(s):  
Simone Corciulo ◽  
Maria Celeste Nicoletti ◽  
Lisa Mastrofrancesco ◽  
Serena Milano ◽  
Maria Mastrodonato ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Functional Role ◽  
Water Channel ◽  
Free Water ◽  
Immunoblotting Analysis ◽  
Homogeneous Population ◽  
Aquaporin 1 ◽  
Non Invasive ◽  
Ultrafiltration Failure

The water channel Aquaporin 1 (AQP1) plays a fundamental role in water ultrafiltration during peritoneal dialysis (PD) and its reduced expression or function may be responsible for ultrafiltration failure (UFF). In humans, AQP1 is expressed in the endothelium of the peritoneal capillaries but its expression in mesothelial cells (MC) and its functional role in PD is still being debated. Here, we studied a cohort of 30 patients using PD in order to determine the presence of AQP1 in peritoneal biopsies, AQP1 release in the PD effluent through exosomes and the correlation of AQP1 abundance with the efficiency of peritoneal ultrafiltration. The experiments using immunofluorescence showed a strong expression of AQP1 in MCs. Immunoblotting analysis on vesicles isolated from PD effluents showed a consistent presence of AQP1, mesothelin and Alix and the absence of the CD31. Thus, this suggests that they have an exclusive mesothelial origin. The immunoTEM analysis showed a homogeneous population of nanovesicles and confirmed the immunoblotting results. Interestingly, the quantitative analysis by ELISA showed a positive correlation between AQP1 in the PD effluent and ultrafiltration (UF), free water transport (FWT) and Na-sieving. This evidence opens the discussion on the functional role of mesothelial AQP1 during PD and suggests that it may represent a potential non-invasive biomarker of peritoneal barrier integrity, with predictive potential of UFF in PD patients.

Potential role of the glial water channel aquaporin-4 in epilepsy

2007 ◽  
Vol 3 (4) ◽  
pp. 287-297 ◽  
Author(s):  
Mike S. Hsu ◽  
Darrin J. Lee ◽  
Devin K. Binder
Keyword(s):  
Synaptic Transmission ◽  
Glial Cells ◽  
Extracellular Space ◽  
Functional Role ◽  
Potential Role ◽  
Water Channel ◽  
Aquaporin 4 ◽  
Membrane Channels ◽  
Human Epilepsy

AbstractRecent studies have implicated glial cells in novel physiological roles in the CNS, such as modulation of synaptic transmission, so it is possible that glial cells might have a functional role in the hyperexcitability that is characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors and transporters have all been associated with the epileptic state. This paper focuses on the potential roles of the glial water channel aquaporin-4 (AQP4) in modulating brain excitability and in epilepsy. We review studies of seizure phenotypes, K+ homeostasis and extracellular space physiology of mice that lack AQP4 (AQP4−/− mice) and discuss the human studies demonstrating alterations of AQP4 in specimens of human epilepsy tissue. We conclude with new studies of AQP4 regulation by seizures and discuss its potential role in the development of epilepsy (epileptogenesis). Although many questions remain unanswered, the available data indicate that AQP4 and its molecular partners might represent important new therapeutic targets.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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