scholarly journals An EGFR autocrine loop encodes a slow‐reacting but dominant mode of mechanotransduction in a polarized epithelium

2010 ◽  
Vol 24 (5) ◽  
pp. 1604-1615 ◽  
Author(s):  
Nikola Kojic ◽  
Euiheon Chung ◽  
Alvin T. Kho ◽  
Jin‐Ah Park ◽  
Austin Huang ◽  
...  
Keyword(s):  
Dominant Mode ◽  
Autocrine Loop ◽  
Polarized Epithelium

On "Diversity" as Anti-Racism in Library and Information Studies: A Critique

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
David James Hudson
Keyword(s):  
Cultural Competence ◽  
Dominant Mode ◽  
Specific Exercise ◽  
Critical Information ◽  
Racial Formations ◽  
Library And Information Studies ◽  
Information Studies ◽  
Library Studies ◽  
Political Economic ◽  
Diversity Discourse

Drawing on a range of critical race and anti-colonial writing, and focusing chiefly on Anglo-Western contexts of librarianship, this paper offers a broad critique of diversity as the dominant mode of anti-racism in LIS. After outlining diversity's core tenets, I examine the ways in which the paradigm's centering of inclusion as a core anti-racist strategy has tended to inhibit meaningful treatment of racism as a structural phenomenon. Situating LIS diversity as a liberal anti-racism, I then turn to diversity's tendency to privilege individualist narratives of (anti-)racism, particularly narratives of cultural competence, and the intersection of such individualism with broader structures of political-economic domination. Diversity's preoccupation with demographic inclusion and individual behavioural competence has, I contend, left little room in the field for substantive engagement with race as a historically contingent phenomenon: race is ultimately reified through LIS diversity discourse, effectively precluding exploration of the ways in which racial formations are differentially produced in the contextually-specific exercise of power itself. I argue that an LIS foregrounding of race as a historical construct - the assumption of its contingency - would enable deeper inquiry into the complex ways in which our field - and indeed the diversity paradigm specifically - aligns with the operations of contemporary regimes of racial subordination in the first place. I conclude with a reflection on the importance of the Journal of Critical Information and Library Studies as a potential site of critical exchange from which to articulate a sustained critique of race in and through our field.

Celiac Disease in Kosovar Albanian Children: Evaluation of Clinical Features and Diagnosis

2020 ◽  
Vol 16 (3) ◽  
pp. 241-247
Author(s):  
Atifete Ramosaj-Morina ◽  
Alije Keka-Sylaj ◽  
Arbana Baloku Zejnullahu ◽  
Lidvana Spahiu ◽  
Virgjina Hasbahta ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Dominant Mode ◽  
Primary School Children ◽  
Cross Sectional ◽  
Classical Form ◽  
Wide Range ◽  
The Mean

Background: Celiac disease is an immune-mediated disorder characterized by variable clinical manifestations, specific antibodies, HLA-DQ2/DQ8 haplotypes, and enteropathy. Objectives: The aim of this study was to present the clinical spectrum and patterns of celiac disease in Kosovar Albanian children. Methods: A cross-sectional retrospective study was performed with Albanian children aged 0-18 years, treated for celiac disease in the Pediatric Clinic, University Clinical Center of Kosovo from 2005 to 2016. Results: During the study period, 63 children were treated for celiac disease. The mean age at diagnosis was 5.5 years (SD ± 3.31). The mean age at celiac disease onset was 3.3 years (SD ± 2.02), while the mean delay from the first symptoms indicative of celiac disease to diagnosis was 2.2 years (SD ± 2.09). More than 70% of the patients were diagnosed in the first 7 years of life, mainly presented with gastrointestinal symptoms, while primary school children and adolescents mostly showed atypical symptoms (p<0.001). The classical form of celiac disease occurred in 78% of the cases. Sixty (95%) patients carried HLA-DQ2.5, DQ2.2 and/or HLA-DQ8 heterodimers, and only three of them tested negative. Conclusions: Kosovo, as the majority of developing countries, is still facing the classical form of celiac disease as the dominant mode of presentation; as a result, most children with other forms of the celiac disease remain undiagnosed. : Physicians should be aware of the wide range of clinical presentations and utilize low testing thresholds in order to prevent potential long-term problems associated with untreated celiac disease.

Stabilization of Dominant Structures in an Ionic Reaction-Diffusion System

1998 ◽  
Vol 63 (6) ◽  
pp. 761-769 ◽  
Author(s):  
Roland Krämer ◽  
Arno F. Münster
Keyword(s):  
Reaction Diffusion ◽  
Dominant Mode ◽  
Reaction Diffusion System ◽  
Diffusion System ◽  
Local Perturbation ◽  
Dimensional System ◽  
One Dimensional ◽  
Brusselator Model ◽  
The One ◽  
Dominant Structure

We describe a method of stabilizing the dominant structure in a chaotic reaction-diffusion system, where the underlying nonlinear dynamics needs not to be known. The dominant mode is identified by the Karhunen-Loeve decomposition, also known as orthogonal decomposition. Using a ionic version of the Brusselator model in a spatially one-dimensional system, our control strategy is based on perturbations derived from the amplitude function of the dominant spatial mode. The perturbation is used in two different ways: A global perturbation is realized by forcing an electric current through the one-dimensional system, whereas the local perturbation is performed by modulating concentrations of the autocatalyst at the boundaries. Only the global method enhances the contribution of the dominant mode to the total fluctuation energy. On the other hand, the local method leads to simple bulk oscillation of the entire system.

scholarly journals Road Maintenance in Africa: Approaches and Perspectives

2018 ◽  
Vol 38 ◽  
pp. 01005
Author(s):  
Mostafa Hassan M
Keyword(s):  
Rural Communities ◽  
Dominant Mode ◽  
Poor Health ◽  
Operating Costs ◽  
Road Maintenance ◽  
Significant Progress ◽  
African Countries ◽  
Institutional Reforms ◽  
Similarities And Differences ◽  
Over Time

In Africa, roads are the dominant mode of passenger and freight transport, for which the need is growing rapidly. It is noticeable that most of the African countries do not do enough to ensure the sustainability of road infrastructure as it has been widely reported that roads are affected, to varying degrees, by premature deterioration. Most of the African countries have adopted institutional reforms, notably entailing the creation of road funds and road agencies, and made significant progress on road maintenance. However, many challenges remain to be addressed in all of them to ensure appropriate maintenance. Although spending on road maintenance has increased over time in all African countries it remains insufficient to cover the needs. Poorly maintained roads constrain mobility, significantly raise vehicle operating costs, increase accident rates and their associated human and property costs, and aggravate isolation, poverty, poor health, and illiteracy in rural communities. This paper focuses, in particular, on road maintenance in some African countries considering types of road maintenance and the different approaches aiming at a comparison to reflect on similarities and differences.

scholarly journals NRG1 fusions in breast cancer

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Karen D. Howarth ◽  
Tashfina Mirza ◽  
Susanna L. Cooke ◽  
Suet-Feung Chin ◽  
Jessica C. Pole ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Kinase Inhibitors ◽  
Cancer Cell Line ◽  
Cytoplasmic Tail ◽  
Gene Fusions ◽  
Breast Cancers ◽  
Autocrine Loop ◽  
Multiple Transcripts ◽  
Autocrine Stimulation

Abstract Background NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The NRG1 gene encodes ligands for the HER2(ERBB2)-ERBB3 heterodimeric receptor tyrosine kinase, and the gene fusions are thought to lead to autocrine stimulation of the receptor. The NRG1 fusion expressed in the breast cancer cell line MDA-MB-175 serves as a model example of such fusions, showing the proposed autocrine loop and exceptional drug sensitivity. However, its structure has not been properly characterised, its oncogenic activity has not been fully explained, and there is limited data on such fusions in breast cancer. Methods We analysed genomic rearrangements and transcripts of NRG1 in MDA-MB-175 and a panel of 571 breast cancers. Results We found that the MDA-MB-175 fusion—originally reported as a DOC4(TENM4)-NRG1 fusion, lacking the cytoplasmic tail of NRG1—is in reality a double fusion, PPP6R3-TENM4-NRG1, producing multiple transcripts, some of which include the cytoplasmic tail. We hypothesise that many NRG1 fusions may be oncogenic not for lacking the cytoplasmic domain but because they do not encode NRG1’s nuclear-localised form. The fusion in MDA-MB-175 is the result of a very complex genomic rearrangement, which we partially characterised, that creates additional expressed gene fusions, RSF1-TENM4, TPCN2-RSF1, and MRPL48-GAB2. We searched for NRG1 rearrangements in 571 breast cancers subjected to genome sequencing and transcriptome sequencing and found four cases (0.7%) with fusions, WRN-NRG1, FAM91A1-NRG1, ARHGEF39-NRG1, and ZNF704-NRG1, all splicing into NRG1 at the same exon as in MDA-MB-175. However, the WRN-NRG1 and ARHGEF39-NRG1 fusions were out of frame. We identified rearrangements of NRG1 in many more (8% of) cases that seemed more likely to inactivate than to create activating fusions, or whose outcome could not be predicted because they were complex, or both. This is not surprising because NRG1 can be pro-apoptotic and is inactivated in some breast cancers. Conclusions Our results highlight the complexity of rearrangements of NRG1 in breast cancers and confirm that some do not activate but inactivate. Careful interpretation of NRG1 rearrangements will therefore be necessary for appropriate patient management.

scholarly journals Stability of a Viscous Liquid Jet in a Coaxial Twisting Compressible Airflow

Processes ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 918
Author(s):  
Li-Mei Guo ◽  
Ming Lü ◽  
Zhi Ning
Keyword(s):  
Viscous Liquid ◽  
Axial Velocity ◽  
Liquid Velocity ◽  
Velocity Ratio ◽  
Dominant Mode ◽  
Liquid Jet ◽  
Axisymmetric Mode ◽  
Jet Instability ◽  
Jet Stability ◽  
Jet Breakup

Based on the linear stability analysis, a mathematical model for the stability of a viscous liquid jet in a coaxial twisting compressible airflow has been developed. It takes into account the twist and compressibility of the surrounding airflow, the viscosity of the liquid jet, and the cavitation bubbles within the liquid jet. Then, the effects of aerodynamics caused by the gas–liquid velocity difference on the jet stability are analyzed. The results show that under the airflow ejecting effect, the jet instability decreases first and then increases with the increase of the airflow axial velocity. When the gas–liquid velocity ratio A = 1, the jet is the most stable. When the gas–liquid velocity ratio A > 2, this is meaningful for the jet breakup compared with A = 0 (no air axial velocity). When the surrounding airflow swirls, the airflow rotation strength E will change the jet dominant mode. E has a stabilizing effect on the liquid jet under the axisymmetric mode, while E is conducive to jet instability under the asymmetry mode. The maximum disturbance growth rate of the liquid jet also decreases first and then increases with the increase of E. The liquid jet is the most stable when E = 0.65, and the jet starts to become more easier to breakup when E = 0.8425 compared with E = 0 (no swirling air). When the surrounding airflow twists (air moves in both axial and circumferential directions), given the axial velocity to change the circumferential velocity of the surrounding airflow, it is not conducive to the jet breakup, regardless of the axisymmetric disturbance or asymmetry disturbance.

Stability of bounded rapid shear flows of a granular material

1996 ◽  
Vol 308 ◽  
pp. 31-62 ◽  
Author(s):  
Chi-Hwa Wang ◽  
R. Jackson ◽  
S. Sundaresan
Keyword(s):  
Growth Rate ◽  
Stability Analysis ◽  
Granular Material ◽  
Bulk Density ◽  
Particulate Material ◽  
Dominant Mode ◽  
Marginal Stability ◽  
Sheared Layer ◽  
The Stability ◽  
Unusual Type

This paper presents a linear stability analysis of a rapidly sheared layer of granular material confined between two parallel solid plates. The form of the steady base-state solution depends on the nature of the interaction between the material and the bounding plates and three cases are considered, in which the boundaries act as sources or sinks of pseudo-thermal energy, or merely confine the material while leaving the velocity profile linear, as in unbounded shear. The stability analysis is conventional, though complicated, and the results are similar in all cases. For given physical properties of the particles and the bounding plates it is found that the condition of marginal stability depends only on the separation between the plates and the mean bulk density of the particulate material contained between them. The system is stable when the thickness of the layer is sufficiently small, but if the thickness is increased it becomes unstable, and initially the fastest growing mode is analogous to modes of the corresponding unbounded problem. However, with a further increase in thickness a new mode becomes dominant and this is of an unusual type, with no analogue in the case of unbounded shear. The growth rate of this mode passes through a maximum at a certain value of the thickness of the sheared layer, at which point it grows much faster than any mode that could be shared with the unbounded problem. The growth rate of the dominant mode also depends on the bulk density of the material, and is greatest when this is neither very large nor very small.

scholarly journals Seasonal Variability of SST Fronts in the Inner Sea of Chiloé and Its Adjacent Coastal Ocean, Northern Patagonia

2021 ◽  
Vol 13 (2) ◽  
pp. 181
Author(s):  
Gonzalo S. Saldías ◽  
Wilber Hernández ◽  
Carlos Lara ◽  
Richard Muñoz ◽  
Cristian Rojas ◽  
...  
Keyword(s):  
Coastal Upwelling ◽  
Environmental Variability ◽  
Function Analysis ◽  
Coastal Ocean ◽  
Dominant Mode ◽  
Early Summer ◽  
High Biological Activity ◽  
Northern Patagonia ◽  
Sst Gradient ◽  
Sst Fronts

Surface oceanic fronts are regions characterized by high biological activity. Here, Sea Surface Temperature (SST) fronts are analyzed for the period 2003–2019 using the Multi-scale Ultra-high Resolution (MUR) SST product in northern Patagonia, a coastal region with high environmental variability through river discharges and coastal upwelling events. SST gradient magnitudes were maximum off Chiloé Island in summer and fall, coherent with the highest frontal probability in the coastal oceanic area, which would correspond to the formation of a coastal upwelling front in the meridional direction. Increased gradient magnitudes in the Inner Sea of Chiloé (ISC) were found primarily in spring and summer. The frontal probability analysis revealed the highest occurrences were confined to the northern area (north of Desertores Islands) and around the southern border of Boca del Guafo. An Empirical Orthogonal Function analysis was performed to clarify the dominant modes of variability in SST gradient magnitudes. The meridional coastal fronts explained the dominant mode (78% of the variance) off Chiloé Island, which dominates in summer, whereas the SST fronts inside the ISC (second mode; 15.8%) were found to dominate in spring and early summer (October–January). Future efforts are suggested focusing on high frontal probability areas to study the vertical structure and variability of the coastal fronts in the ISC and its adjacent coastal ocean.

Scattering by a semi-infinite resistive strip of dominant-mode propagation in an infinite rectangular wave-guide

1956 ◽  
Vol 52 (3) ◽  
pp. 553-563 ◽  
Author(s):  
V. M. Papadopoulos
Keyword(s):  
Electric Field ◽  
Digital Computer ◽  
Transverse Electric ◽  
Dominant Mode ◽  
Surface Resistivity ◽  
Wave Guide ◽  
Mode Propagation ◽  
Rectangular Wave ◽  
Electric Mode ◽  
Transverse Electric Mode

ABSTRACTThe scattering of the dominant transverse electric mode in an infinite perfectly conducting rectangular wave-guide by a semi-infinite resistive strip, centrally placed and parallel to the electric field, is calculated by the use of Laplace transforms. Formulae are derived for the amplitude of the scattered waves, and the numerical results, obtained using a digital computer, are given for various values of the surface resistivity of the strip.

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