Modulatory effect of ionizing radiation on food‐NaCl associative learning: the role of γ subunit of G protein in Caenorhabditis elegans

2007 ◽  
Vol 22 (3) ◽  
pp. 713-720 ◽  
Author(s):  
Tetsuya Sakashita ◽  
Nobuyuki Hamada ◽  
Daisuke D. Ikeda ◽  
Sumino Yanase ◽  
Michiyo Suzuki ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Ionizing Radiation ◽  
Associative Learning ◽  
G Protein ◽  
Γ Subunit

scholarly journals GPC-1, a G Protein γ-Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans

Genetics ◽  
2009 ◽  
Vol 181 (4) ◽  
pp. 1347-1357 ◽  
Author(s):  
Koji Yamada ◽  
Takaaki Hirotsu ◽  
Masahiro Matsuki ◽  
Hirofumi Kunitomo ◽  
Yuichi Iino
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Γ Subunit ◽  
Olfactory Adaptation

scholarly journals Role of Isoprenoid Lipids on the Heterotrimeric G Protein γ Subunit in Determining Effector Activation

1999 ◽  
Vol 274 (23) ◽  
pp. 16595-16603 ◽  
Author(s):  
Chang-Seon Myung ◽  
Hiroshi Yasuda ◽  
Wendy W. Liu ◽  
T. Kendall Harden ◽  
James C. Garrison
Keyword(s):  
G Protein ◽  
Heterotrimeric G Protein ◽  
Γ Subunit

scholarly journals Role of the G Protein γ Subunit in βγ Complex Modulation of Phospholipase Cβ Function

2002 ◽  
Vol 277 (22) ◽  
pp. 19573-19578 ◽  
Author(s):  
Muslum Akgoz ◽  
Inaki Azpiazu ◽  
Vani Kalyanaraman ◽  
N. Gautam
Keyword(s):  
G Protein ◽  
Γ Subunit ◽  
Complex Modulation

scholarly journals Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30

2021 ◽  
Author(s):  
Benson Otarigho ◽  
Alejandro Aballay
Keyword(s):  
Nervous System ◽  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
Neural Control ◽  
Dependent Manner ◽  
G Protein Coupled ◽  
Y Receptors ◽  
Neuropeptide Y Receptors

A body of evidence indicates that metazoan immune and aging pathways are largely interconnected, but the mechanisms involved in their homeostatic control remain unclear. In this study, we found that the PITX (paired like homeodomain) transcription factor UNC-30 controls the tradeoff between immunity and longevity from the nervous system in Caenorhabditis elegans. PITX/UNC-30 functional loss enhanced immunity in a GATA/ELT-2- and p38 MAPK/PMK-1-dependent manner and reduced longevity by activating the MXD/MDL-1 and PQM-1 pathways. The immune inhibitory and longevity stimulatory functions of PITX/UNC-30 required the sensory neuron ASG and a neurotransmitter signaling pathway controlled by NPR-1, which is a G protein-coupled receptor related to mammalian neuropeptide Y receptors. Our findings uncovered a suppressive role of GABAergic signaling in the neural control of a biological tradeoff where energy is allocated towards immunity at the expense of longevity.

Attraction to pheromones in Caenorhabditis elegans can be reversed through associative learning

2018 ◽  
Author(s):  
M. Dal Bello ◽  
A. Pérez-Escudero ◽  
F. C. Schroeder ◽  
J. Gore
Keyword(s):  
Caenorhabditis Elegans ◽  
Associative Learning ◽  
Behavioral Plasticity ◽  
Current Knowledge ◽  
Natural Environments ◽  
Chemical Signaling ◽  
Learning Abilities ◽  
C Elegans ◽  
Pheromone Blend

AbstractDespite the ubiquity and importance of chemical signaling, we have only limited insight about the role of learning in the response to pheromones. Here, we demonstrate that responses to pheromones can be reprogrammed through associative learning. In particular, we show that attraction to ascaroside pheromones in the model nematode Caenorhabditis elegans can be reversed by training the animals to associate either a pheromone blend or single synthetic ascarosides with the lack of food. This behavioral plasticity alters worm preference for pheromones following consumption of a food patch, possibly improving foraging in natural environments. By bridging the gap between the current knowledge on the chemical language and the learning abilities of C. elegans, we provide insight on the possible links between learning and chemical signaling in animals.

scholarly journals Role of the γ Subunit Prenyl Moiety in G Protein βγ Complex Interaction with Phospholipase Cβ

2001 ◽  
Vol 276 (45) ◽  
pp. 41797-41802 ◽  
Author(s):  
Vanessa C. Fogg ◽  
Inaki Azpiazu ◽  
Maurine E. Linder ◽  
Alan Smrcka ◽  
Suzanne Scarlata ◽  
...  
Keyword(s):  
G Protein ◽  
Complex Interaction ◽  
Γ Subunit

scholarly journals Role of the Prenyl Group on the G Protein γ Subunit in Coupling Trimeric G Proteins to A1 Adenosine Receptors

1996 ◽  
Vol 271 (31) ◽  
pp. 18588-18595 ◽  
Author(s):  
Hiroshi Yasuda ◽  
Margaret A. Lindorfer ◽  
Karen A. Woodfork ◽  
Julia E. Fletcher ◽  
James C. Garrison
Keyword(s):  
G Protein ◽  
G Proteins ◽  
Adenosine Receptors ◽  
Γ Subunit ◽  
A1 Adenosine Receptors
Sign in / Sign up

Export Citation Format

Share Document