An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing

2007 ◽  
Vol 22 (2) ◽  
pp. 569-578 ◽  
Author(s):  
Kaija J. Autio ◽  
Alexander J. Kastaniotis ◽  
Helmut Pospiech ◽  
Ilkka J. Miinalainen ◽  
Melissa S. Schonauer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Rna Processing ◽  
Acid Synthesis ◽  
Genetic Link ◽  
Mitochondrial Fatty Acid

An ancient genetic link between mitochondrial fatty acid synthesis and RNA processing

2007 ◽  
Vol 149 ◽  
pp. S21
Author(s):  
Kaija Autio ◽  
Alexander Kastaniotis ◽  
Helmut Pospiech ◽  
Ilkka Miinalainen ◽  
Melissa Schonauer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Rna Processing ◽  
Acid Synthesis ◽  
Genetic Link ◽  
Mitochondrial Fatty Acid

scholarly journals HFA1 Encoding an Organelle-specific Acetyl-CoA Carboxylase Controls Mitochondrial Fatty Acid Synthesis inSaccharomyces cerevisiae

2004 ◽  
Vol 279 (21) ◽  
pp. 21779-21786 ◽  
Author(s):  
Ursula Hoja ◽  
Sandra Marthol ◽  
Jörg Hofmann ◽  
Sabine Stegner ◽  
Rainer Schulz ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Mitochondrial Fatty Acid

scholarly journals Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis

2018 ◽  
Vol 28 (20) ◽  
pp. R1212-R1219 ◽  
Author(s):  
Sara M. Nowinski ◽  
Jonathan G. Van Vranken ◽  
Katja K. Dove ◽  
Jared Rutter
Keyword(s):  
Fatty Acid ◽  
Mitochondrial Biogenesis ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Mitochondrial Fatty Acid

scholarly journals Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice

2018 ◽  
Vol 38 (45) ◽  
pp. 9781-9800 ◽  
Author(s):  
Remya R. Nair ◽  
Henna Koivisto ◽  
Kimmo Jokivarsi ◽  
Ilkka J. Miinalainen ◽  
Kaija J. Autio ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Mitochondrial Fatty Acid

scholarly journals Mitochondrial fatty acid synthesis and respiration

2010 ◽  
Vol 1797 ◽  
pp. 78
Author(s):  
J. Kalervo Hiltunen ◽  
Kaija J. Autio ◽  
Melissa S. Schonauer ◽  
V.A. Samuli Kursu ◽  
Carol L. Dieckmann ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Mitochondrial Fatty Acid

scholarly journals Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151171 ◽  
Author(s):  
Hayley B. Clay ◽  
Angelika K. Parl ◽  
Sabrina L. Mitchell ◽  
Larry Singh ◽  
Lauren N. Bell ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Lipid Profiles ◽  
Metabolomic Profiling ◽  
Metabolic States ◽  
Mitochondrial Fatty Acid

scholarly journals Intersection of RNA Processing and the Type II Fatty Acid Synthesis Pathway in Yeast Mitochondria

2008 ◽  
Vol 28 (21) ◽  
pp. 6646-6657 ◽  
Author(s):  
Melissa S. Schonauer ◽  
Alexander J. Kastaniotis ◽  
J. Kalervo Hiltunen ◽  
Carol L. Dieckmann
Keyword(s):  
Fatty Acid ◽  
Lipoic Acid ◽  
Rna Processing ◽  
Mitochondrial Gene ◽  
Rnase P ◽  
Acid Synthesis ◽  
Mitochondrial Enzymes ◽  
Type Ii ◽  
Mitochondrial Fatty Acid ◽  
Fas Ii

ABSTRACT Distinct metabolic pathways can intersect in ways that allow hierarchical or reciprocal regulation. In a screen of respiration-deficient Saccharomyces cerevisiae gene deletion strains for defects in mitochondrial RNA processing, we found that lack of any enzyme in the mitochondrial fatty acid type II biosynthetic pathway (FAS II) led to inefficient 5′ processing of mitochondrial precursor tRNAs by RNase P. In particular, the precursor containing both RNase P RNA (RPM1) and tRNAPro accumulated dramatically. Subsequent Pet127-driven 5′ processing of RPM1 was blocked. The FAS II pathway defects resulted in the loss of lipoic acid attachment to subunits of three key mitochondrial enzymes, which suggests that the octanoic acid produced by the pathway is the sole precursor for lipoic acid synthesis and attachment. The protein component of yeast mitochondrial RNase P, Rpm2, is not modified by lipoic acid in the wild-type strain, and it is imported in FAS II mutant strains. Thus, a product of the FAS II pathway is required for RNase P RNA maturation, which positively affects RNase P activity. In addition, a product is required for lipoic acid production, which is needed for the activity of pyruvate dehydrogenase, which feeds acetyl-coenzyme A into the FAS II pathway. These two positive feedback cycles may provide switch-like control of mitochondrial gene expression in response to the metabolic state of the cell.

Mitochondrial fatty acid synthesis and maintenance of respiratory competent mitochondria in yeast

2005 ◽  
Vol 33 (5) ◽  
pp. 1162 ◽  
Author(s):  
F. Okubo ◽  
J.K. Hiltunen ◽  
V.A.S. Kursu ◽  
K.J. Autio ◽  
A.J. Kastaniotis
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Mitochondrial Fatty Acid
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