Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major

2007 ◽  
Vol 21 (12) ◽  
pp. 3208-3218 ◽  
Author(s):  
Jan Ehrchen ◽  
Laura Helming ◽  
Georg Varga ◽  
Bastian Pasche ◽  
Karin Loser ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Leishmania Major ◽  
Receptor Signaling ◽  
Susceptibility To Infection

scholarly journals Nutraceuticals Derived From Pomegranate Selectively Enhance Vitamin D Receptor Signaling to Amplify Key Vitamin D Target Genes

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Sarah Livingston ◽  
Daniel Lucas ◽  
Marya S. Sabir ◽  
Sanchita Mallick ◽  
Hespera Purdin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Target Genes ◽  
Receptor Signaling

scholarly journals The Role of Vitamin D and Vitamin D Receptor in Immunity toLeishmania majorInfection

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
James P. Whitcomb ◽  
Mary DeAgostino ◽  
Mark Ballentine ◽  
Jun Fu ◽  
Martin Tenniswood ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune Responses ◽  
Vitamin D Receptor ◽  
Leishmania Major ◽  
Active Form ◽  
Wild Type ◽  
Vitamin D Signaling ◽  
Deficient Mice ◽  
Th 1

Vitamin D signaling modulates a variety of immune responses. Here, we assessed the role of vitamin D in immunity to experimental leishmaniasis infection in vitamin D receptor-deficient mice (VDRKO). We observed that VDRKO mice on a genetically resistant background have decreasedLeishmania major-induced lesion development compared to wild-type (WT) mice; additionally, parasite loads in infected dermis were significantly lower at the height of infection. Enzymatic depletion of the active form of vitamin D mimics the ablation of VDR resulting in an increased resistance toL. major. Conversely, VDRKO or vitamin D-deficient mice on the susceptible Th2-biased background had no change in susceptibility. These studies indicate vitamin D deficiency, either through the ablation of VDR or elimination of its ligand, 1,25D3, leads to an increase resistance toL. majorinfection but only in a host that is predisposed for Th-1 immune responses.

scholarly journals 289 Tight Junction Protein Claudin-2 Is a Direct Target of Vitamin D Receptor Signaling in Intestinal Epithelium

2014 ◽  
Vol 146 (5) ◽  
pp. S-69
Author(s):  
Yong-guo Zhang ◽  
Shaoping Wu ◽  
Rong Lu ◽  
Zhongren Zhou ◽  
Elaine O. Petrof ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tight Junction ◽  
Vitamin D Receptor ◽  
Intestinal Epithelium ◽  
Tight Junction Protein ◽  
Receptor Signaling ◽  
Junction Protein ◽  
Direct Target

scholarly journals Vitamin D Receptor Signaling Enhances Locomotive Ability in Mice

2014 ◽  
Vol 30 (1) ◽  
pp. 128-136 ◽  
Author(s):  
Sadaoki Sakai ◽  
Miho Suzuki ◽  
Yoshihito Tashiro ◽  
Keisuke Tanaka ◽  
Satoshi Takeda ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Signaling

scholarly journals Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

2013 ◽  
Vol 123 (9) ◽  
pp. 3983-3996 ◽  
Author(s):  
Weicheng Liu ◽  
Yunzi Chen ◽  
Maya Aharoni Golan ◽  
Maria L. Annunziata ◽  
Jie Du ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Experimental Colitis ◽  
Intestinal Epithelial ◽  
Receptor Signaling

scholarly journals Dysregulated Krüppel-Like Factor 4 and Vitamin D Receptor Signaling Contribute to Progression of Hepatocellular Carcinoma

2012 ◽  
Vol 143 (3) ◽  
pp. 799-810.e2 ◽  
Author(s):  
Qi Li ◽  
Yong Gao ◽  
Zhiliang Jia ◽  
Lopa Mishra ◽  
Kun Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Signaling
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