Regulation of the human atrial myosin light chain 1 promoter by Ca 2+ ‐calmodulin‐dependent signaling pathways

2005 ◽  
Vol 19 (6) ◽  
pp. 1-9 ◽  
Author(s):  
Christiane Woischwill ◽  
Peter Karczewski ◽  
Holger Bartsch ◽  
Hans-Peter Luther ◽  
Monika Kott ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Atrial Myosin

scholarly journals Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis

1994 ◽  
Vol 269 (24) ◽  
pp. 16961-16970
Author(s):  
S.W. Kubalak ◽  
W.C. Miller-Hance ◽  
T.X. O'Brien ◽  
E. Dyson ◽  
K.R. Chien
Keyword(s):  
Light Chain ◽  
Myosin Light Chain ◽  
Myosin Light Chain 2 ◽  
Atrial Myosin

Abstract WMP39: Protein Phosphatase 1 Regulatory Subunit 12C Contributes to Atrial Myosin Light Chain Dephosphorylation in Atrial Fibrillation

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Srikanth Perike ◽  
Katherina M Alsina ◽  
Arvind Sridhar ◽  
Dawood Darbar ◽  
Xander Wehrens ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Light Chain ◽  
Protein Phosphatase ◽  
Myosin Light Chain ◽  
Stroke Risk ◽  
Contractile Function ◽  
Protein Phosphatase 1 ◽  
Regulatory Subunit ◽  
Western Blots ◽  
Atrial Myosin

Background: Atrial fibrillation (AF) increases stroke risk five-fold. Atrial hypocontractility from atrial myosin light chain (MLC2a) dephosphorylation contributes to stroke risk in AF. Recent proteomic data has shown increased protein phosphatase 1 subunit 12C (PPP1R12C) targeting to MLC2a in AF. However, it is unclear whether PPP1R12C causes MLC2a dephosphorylation in AF. Objective: Determine whether increased PPP1R12C expression causes MLC2a dephosphorylation and increases AF risk. Methods: Western blots and co-IPs were performed to evaluate the relationship among PPP1R12C, PP1c and MLC2a in human atrial tissues (AF vs SR). Mice with either a knockout (KO) or lentiviral (LV) cardiac overexpression of PPP1R12C were evaluated with invasive EP studies for AF inducibility vs WT controls. Results: In human AF, PPP1R12C was increased 4-fold ( P <0.005, n=6) with an 88% reduction in S-19-MLC2a phosphorylation ( P <0.05, n=4). PPP1R12C-PP1c and PPP1R12C-MLC2a binding was increased 2-fold in AF ( P <0.05, n=6). AF burden in LV-12C mice increased nearly tenfold vs. KO and WT mice ( P <0.05, n=6). Conclusion: In human AF, increased PPP1R12C expression is associated with reduced P-MLC2a through enhanced binding with the PP1c catalytic subunit. This dephosphorylation is a likely contributor to atrial hypocontractility and stroke risk in AF. Additionally, increased PPP1R12C expression in mice increases AF risk. Future studies will examine the effects of increased PPP1R12C expression upon atrial contractile function in mice.

scholarly journals Regional Difference in Expression of Atrial Myosin Light Chain 1 in the Human Ventricle of Old Myocardial Infarction.

1991 ◽  
Vol 55 ◽  
pp. 406
Author(s):  
Koichi Nakao ◽  
Kazuteru Fuiimoto ◽  
Michihisa Joueasaki ◽  
Hirofumi Yasue ◽  
Yasumichi Hitoshi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Regional Difference ◽  
Old Myocardial Infarction ◽  
Atrial Myosin

Human Atrial Myosin Light Chain 1 Expression Attenuates Heart Failure

2007 ◽  
pp. 283-292 ◽  
Author(s):  
Ahmed Ihab Abdelaziz ◽  
Ines Pagel ◽  
Wolfgang-Peter Schlegel ◽  
Monika Kott ◽  
Jan Monti ◽  
...  
Keyword(s):  
Heart Failure ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Atrial Myosin

PPP1R12C REGULATES MYOCARDIAL CONTRACTILITY THROUGH DEPHOSPHORYLATION OF ATRIAL MYOSIN LIGHT CHAIN

2019 ◽  
Vol 73 (9) ◽  
pp. 827 ◽  
Author(s):  
Srikanth Perike ◽  
Katherina Alsina ◽  
Arvind Sridhar ◽  
Andrielle Capote ◽  
Jody Marin ◽  
...  
Keyword(s):  
Light Chain ◽  
Myocardial Contractility ◽  
Myosin Light Chain ◽  
Atrial Myosin

Increased expression of atrial myosin light chain 1 in the overloaded human left ventricle: possible expression of fetal type myocytes

1992 ◽  
Vol 36 (3) ◽  
pp. 315-328 ◽  
Author(s):  
Koichi Nakao ◽  
Hirofumi Yasue ◽  
Kazuteru Fujimoto ◽  
Ken Okumura ◽  
Hideyuki Yamamoto ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Human Left Ventricle ◽  
Atrial Myosin

Phosphorylation events associated with cyclic nucleotidedependent inhibition of smooth muscle contraction

1999 ◽  
Vol 277 (3) ◽  
pp. H931-H939 ◽  
Author(s):  
David A. Woodrum ◽  
Colleen M. Brophy ◽  
Christopher J. Wingard ◽  
Arthur Beall ◽  
Howard Rasmussen
Keyword(s):  
Smooth Muscle ◽  
Oxygen Consumption ◽  
Carotid Artery ◽  
Signaling Pathways ◽  
Light Chain ◽  
Cyclic Nucleotide ◽  
Myosin Light Chain ◽  
Umbilical Artery ◽  
Smooth Muscle Contraction ◽  
Myosin Light Chain Phosphorylation

Activation of cyclic nucleotide-dependent signaling pathways leads to relaxation of bovine carotid artery smooth muscle contractions and is associated with increased phosphorylation of the small heat shock-related protein (HSP20). Previous reports have shown that human umbilical artery smooth muscle is uniquely resistant to cyclic nucleotide-dependent relaxation, and HSP20 is not phosphorylated. In this investigation, we determined the phosphorylation events associated with cyclic nucleotide-dependent inhibition of smooth muscle contraction. In carotid artery, activation of cyclic nucleotide-dependent signaling pathways inhibited contractile responses to serotonin but did not inhibit myosin light chain phosphorylation or oxygen consumption. The inhibition of contraction was associated with increases in HSP20 phosphorylation. In umbilical artery, activation of cyclic nucleotide-dependent signaling pathways did not inhibit serotonin-induced contraction or myosin light chain phosphorylation. The lack of contractile inhibition in umbilical artery was not associated with significant increases in HSP20 phosphorylation. In conclusion, cyclic nucleotide-dependent contractile inhibition is independent of the inhibition of myosin light chain phosphorylation or oxygen consumption but does correlate with increased HSP20 phosphorylation.

scholarly journals Masticatory (`superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw-closing muscles

2009 ◽  
Vol 212 (16) ◽  
pp. 2511-2519 ◽  
Author(s):  
P. J. Reiser ◽  
S. Bicer ◽  
Q. Chen ◽  
L. Zhu ◽  
N. Quan
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Atrial Myosin
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