Mechanical stretch activates nuclear factor‐kappaB, activator protein‐1, and mitogen‐activated protein kinases in lung parenchyma: implications in asthma

2003 ◽  
Vol 17 (13) ◽  
pp. 1800-1811 ◽  
Author(s):  
Ashok Kumar ◽  
Savita Lnu ◽  
Rahul Malya ◽  
David Barron ◽  
Joan Moore ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Mechanical Stretch ◽  
Lung Parenchyma ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Activator Protein 1 ◽  
Mitogen Activated Protein Kinases ◽  
Activator Protein ◽  
Mitogen Activated Protein

scholarly journals (465) Inhibitory Effect of Lingonberry (Vaccinium vitis-idaea L.) Extracts on Activator Protein-1, Nuclear Factor-KappaB, and Mitogen-activated Protein Kinases

HortScience ◽  
2005 ◽  
Vol 40 (4) ◽  
pp. 1090D-1090
Author(s):  
Shiow Wang ◽  
Ren-tian Feng ◽  
Linda Bowman ◽  
Ross Penhallegon ◽  
Min Ding
Keyword(s):  
Protein Kinases ◽  
Neoplastic Transformation ◽  
Nuclear Factor Kappab ◽  
Human Leukemia ◽  
Nuclear Factor ◽  
Activator Protein 1 ◽  
Mitogen Activated Protein Kinases ◽  
Activator Protein ◽  
Mitogen Activated Protein ◽  
Dose Dependent

The effects of lingonberry (Vaccinium vitis-idaea L.) extracts on activator protein-1 (AP-1), nuclear factor-kappaB (NF-κB), and mitogen-activated protein kinases (MAPKs) were evaluated. Pretreatment of JB6 P+ mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition of AP-1 and NF-κB induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB) light. Lingonberry extracts blocked UVB-induced phosphorylation of MAPK family members ERK1, ERK2, and p38, but not JNK. Lingonberry extracts also prevented TPA-induced phosphorylation of ERK1 and ERK2. Results of soft agar assays indicated that lingonberry extracts suppressed TPA-induced neoplastic transformation of JB6 P+ cells in a dose-dependent manner. Lingonberry extracts also induced the apoptosis of human leukemia HL-60 cells in a dose-independent manner. These results suggest that ERK1 and ERK2 may be inhibited by lingonberries, which results in suppression of AP-1 and neoplastic transformation in JB6 P+ cells and causes cancer cell death by an apoptotic mechanism in human leukemia HL-60 cells.

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