Negative regulatory role of overexpression of PLCγ1in the expression of early growth response 1 gene in rat 3Y1 fibroblasts

2002 ◽  
Vol 16 (12) ◽  
pp. 1504-1514 ◽  
Author(s):  
Soon Young Shin ◽  
Jesang Ko ◽  
Jong‐Soo Chang ◽  
Do Sik Min ◽  
Chan Choi ◽  
...  
Keyword(s):  
Growth Response ◽  
Early Growth ◽  
Regulatory Role ◽  
Early Growth Response ◽  
Early Growth Response 1 ◽  
Negative Regulatory Role

scholarly journals Regulation and action of early growth response 1 in bovine granulosa cells

Reproduction ◽  
2017 ◽  
Vol 154 (4) ◽  
pp. 547-557 ◽  
Author(s):  
Peng Han ◽  
Hilda Guerrero-Netro ◽  
Anthony Estienne ◽  
Binyun Cao ◽  
Christopher A Price
Keyword(s):  
Granulosa Cells ◽  
Tyrosine Kinases ◽  
Growth Response ◽  
Early Growth ◽  
Mrna Abundance ◽  
Mrna Levels ◽  
Early Growth Response ◽  
Cell Proliferation And Differentiation ◽  
Early Growth Response 1

Fibroblast growth factors (FGF) modify cell proliferation and differentiation through receptor tyrosine kinases, which stimulate the expression of transcription factors including members of the early growth response (EGR) family. In ovarian granulosa cells, most FGFs activate typical response genes, although the role of EGR proteins has not been described. In the present study, we determined the regulation of EGR mRNA by FGFs and explored the role of EGR1 in the regulation of FGF-response genes. Addition of FGF1, FGF2, FGF4 or FGF8b increased EGR1 and EGR3 mRNA levels, whereas FGF18 increased only EGR1 mRNA abundance. No mRNA encoding EGR2 or EGR4 was detected. Overexpression of EGR1 increased EGR3 mRNA levels as well as the FGF-response genes SPRY2, NR4A1 and FOSL1 and also increased the phosphorylation of MAPK3/1. Knockdown of EGR3 did not alter the ability of FGF8b to stimulate SPRY2 mRNA levels. These data demonstrate the regulation of EGR1 and EGR3 mRNA abundance by FGFs in granulosa cells and suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.

scholarly journals Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling

2006 ◽  
Vol 281 (12) ◽  
pp. 8161-8168 ◽  
Author(s):  
Soo Jung Cho ◽  
Min Jong Kang ◽  
Robert J. Homer ◽  
Hye Ryun Kang ◽  
Xuchen Zhang ◽  
...  
Keyword(s):  
Growth Response ◽  
Early Growth ◽  
Early Growth Response ◽  
Interleukin 13 ◽  
Early Growth Response 1

scholarly journals p21Waf1/Cip1 Expression by Curcumin in U-87MG Human Glioma Cells: Role of Early Growth Response-1 Expression

2008 ◽  
Vol 68 (5) ◽  
pp. 1369-1377 ◽  
Author(s):  
Byeong Hyeok Choi ◽  
Chang Gun Kim ◽  
Young-Seuk Bae ◽  
Yoongho Lim ◽  
Young Han Lee ◽  
...  
Keyword(s):  
Growth Response ◽  
Glioma Cells ◽  
Early Growth ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Early Growth Response ◽  
Early Growth Response 1

scholarly journals Role of alveolar epithelial early growth response-1 (Egr-1) in CD8+ T cell-mediated lung injury

2009 ◽  
Vol 47 (2-3) ◽  
pp. 623-631 ◽  
Author(s):  
Chilakamarti V. Ramana ◽  
Guang-Shing Cheng ◽  
Aseem Kumar ◽  
Hyung-Joo Kwon ◽  
Richard I. Enelow
Keyword(s):  
T Cell ◽  
Lung Injury ◽  
Growth Response ◽  
Cd8 T Cell ◽  
Early Growth ◽  
Early Growth Response ◽  
Alveolar Epithelial ◽  
Early Growth Response 1
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